CALGARY--The head of Royal Dutch Shell PLC's Canadian unit Wednesday said the company may not be able to meet promised targets for reducing toxic wastes from oil sands and called for greater regulatory flexibility.

Shell, which operates two major oil-sands surface mines in northern Alberta, had committed to cutting the amount of waste generated by its heavy-oil extraction projects in Canada. But the company and other producers have struggled to meet reduction targets mandated by the government and now face the prospect of penalties if those goals remain unmet.

"It's going to be very challenging" to achieve mandated reduction targets next year, said Lorraine Mitchelmore, president of Shell Canada Ltd.

Growth in natural gas and oil sands is a core focus for the energy company, she said, adding the company is committed to its operations in Canada as a "multi-decade opportunity."

Ms. Mitchelmore said Shell hopes to link inland sources of natural gas to a proposed liquefied natural gas export terminal on Canada's Pacific coast, though the company hasn't made a final investment decision yet.

She also said Shell's Canadian oil-sands operations meet the company's internal yardstick for profitability as long as prices of Brent crude remain above the $70 mark.

The company has had less success in reducing the environmental impact of wastes generated by its oil sands operations, even though Shell says it has reduced the intensity of its greenhouse gas emissions and use of fresh water.

Alberta's Energy Resources Conservation Board, the province's chief regulatory authority, last year said Shell's two oil-sands mines and two others owned by rivals, Suncor Energy Inc. and Syncrude Canada Ltd., each failed to meet cleanup goals in at least one of two cumulative periods measured.

It found that not only did the amount of waste generated not go down, but actually increased in line with greater oil-sands production. The report followed-up on a policy implemented in 2009 known as Directive 74, which laid out specific targets for reducing oil sands wastes and reclaiming waste-storage ponds in the boreal forests where the industry is centered.

The regulator waived penalties, citing industry progress in introducing new technology, but warned operators to make up any shortfalls and said it would "assess enforcement options" in a follow-up report due in 2015.

That move angered environmental groups and raised questions about the province's commitment to reducing or eliminating so-called tailings ponds of fluid waste.

Oil-sand wastes, which are toxic in high concentrations, are a byproduct of mining when bitumen, or heavy oil, is separated from clay, sand and silt. The tailing ponds where wastes are collected have become a magnet for critics, who say they are an eyesore and dangerous to wildlife.

Ms. Mitchelmore said Shell and other oil-sands strip-mine operators have urged Alberta's government to ease requirements to allow the industry more time and flexibility. "Prescriptive regulation puts you in a box," she said.

Last year, then-premier Alison Redford said fluid tailings growth would be halted by 2016 and that tailing ponds would "disappear from Alberta's landscape in the very near future."

Industry executives say that is not realistic. Ms. Mitchelmore said tailings may be eliminated one day, but not anytime soon. "Timeline? I don't know," she said.

Write to Chester Dawson at chester.dawson@wsj.com

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