TIDMSHP 
 
 
   Director/PDMR Shareholding 
 
   December 14, 2018 -- Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company") 
 
   Notification of transactions by person discharging managerial 
responsibilities 
 
 
 
 
     Details of the person discharging managerial 
      responsibilities ("PDMR") / person closely 
1.    associated with them ("PCA") 
---  ----------------------------------------------------------------------- 
a)   Name                        Bill Mordan 
---  --------------------------  ------------------------------------------- 
2.   Reason for the notification 
---  ----------------------------------------------------------------------- 
                                 General Counsel and Company Secretary 
a)   Position / status            - PDMR 
---  --------------------------  ------------------------------------------- 
     Initial notification 
b)    / amendment                Initial notification 
---  --------------------------  ------------------------------------------- 
     Details of the issuer, emission allowance 
      participant, auction platform, auctioneer 
3.    or auction monitor 
---  ----------------------------------------------------------------------- 
a)   Name                        Shire plc 
---  --------------------------  ------------------------------------------- 
b)   LEI                         54930005LQRLI2UXRQ59 
---  --------------------------  ------------------------------------------- 
     Details of the transaction(s): section to 
      be repeated for (i) each type of instrument; 
      (ii) each type of transaction; (iii) each 
      date; and (iv) each place where transactions 
4.    have been conducted 
---  ----------------------------------------------------------------------- 
     Description 
      of the financial 
      instrument,                Shire plc American Depositary 
      type of instrument          Shares ("ADSs") 
--- 
     Identification 
a)    code                       ISIN: US82481R1068 
---  --------------------------  ------------------------------------------- 
                                 Receipt of ADSs following the 
                                  vesting of Performance Stock Units 
                                  ("PSUs") awarded under the Shire 
                                  Long Term Incentive Plan 2015 
                                  ("LTIP") on February 26, 2016. 
                                  In accordance with: 
                                  (i) the Co-Operation Agreement 
                                  between the Company and Takeda 
                                  Pharmaceutical Company Limited 
                                  dated May 8, 2018, and the rules 
                                  of the LTIP: 
                                  a. 100% of the PSUs vested pursuant 
                                  to applicable performance conditions; 
                                  b. vesting of the PSUs was accelerated 
                                  relative to the normal vesting 
                                  date; and 
                                  (ii) the rules of the LTIP, upon 
                                  vesting the number of ADSs to 
                                  be delivered was increased by 
                                  an amount equivalent to the value 
                                  of dividends paid by the Company 
                                  in respect of the PSUs from the 
                                  award date to the date of vesting. 
                                  (Details of related disposal of 
     Nature of the                ADSs are referenced in section 
b)    transaction                 5. below.) 
---  --------------------------  ------------------------------------------- 
                                        Price(s)              Volume(s) 
---  --------------------------  ----------------------  ------------------- 
     Price(s) and 
c)    volume(s)                   $                   0                8,853 
---  --------------------------      ------------------  ------------------- 
     Aggregated information 
      - Aggregated 
d)    volume - Price                                N/A (single transaction) 
---  --------------------------  ------------------------------------------- 
     Date of the 
e)    transaction                                          December 11, 2018 
---  --------------------------  ------------------------------------------- 
     Place of the 
f)    transaction                                                        N/A 
---  --------------------------  ------------------------------------------- 
     Details of the transaction(s): section to 
      be repeated for (i) each type of instrument; 
      (ii) each type of transaction; (iii) each 
      date; and (iv) each place where transactions 
5.    have been conducted 
---  ----------------------------------------------------------------------- 
     Description 
      of the financial 
      instrument,                              Shire plc American Depositary 
      type of instrument                                     Shares ("ADSs") 
--- 
     Identification 
a)    code                                                ISIN: US82481R1068 
---  --------------------------  ------------------------------------------- 
                                               Automated disposal of ADSs in 
                                             relation to the vesting of PSUs 
                                             referenced in section 4. above. 
                                               The proceeds of this disposal 
                                               were used to satisfy personal 
     Nature of the                          tax liabilities arising from the 
b)    transaction                                       vesting of the PSUs. 
---  --------------------------  ------------------------------------------- 
                                        Price(s)                   Volume(s) 
---  --------------------------  ----------------------  ------------------- 
     Price(s) and 
c)    volume(s)                   $            169.6625                3,983 
---  --------------------------      ------------------  ------------------- 
d)   Aggregated information      N/A (single transaction) 
      - Aggregated 
      volume - Price 
---  --------------------------  ------------------------------------------- 
e)   Date of the                 December 11, 2018 
      transaction 
---  --------------------------  ------------------------------------------- 
f)   Place of the                NASDAQ 
      transaction 
---  --------------------------  ------------------------------------------- 
 
 
 
 
 
 
      Details of the person discharging managerial 
       responsibilities ("PDMR") / person closely 
1.     associated with them ("PCA") 
----  ----------------------------------------------------------------------- 
a)    Name                        Joanne Cordeiro 
----  --------------------------  ------------------------------------------- 
2.    Reason for the notification 
----  ----------------------------------------------------------------------- 
                                  Chief Human Resources Officer 
a)    Position / status            -- PDMR 
----  --------------------------  ------------------------------------------- 
      Initial notification 
b)     / amendment                Initial notification 
----  --------------------------  ------------------------------------------- 
      Details of the issuer, emission allowance 
       participant, auction platform, auctioneer 
3.     or auction monitor 
----  ----------------------------------------------------------------------- 
a)    Name                        Shire plc 
----  --------------------------  ------------------------------------------- 
b)    LEI                         54930005LQRLI2UXRQ59 
----  --------------------------  ------------------------------------------- 
      Details of the transaction(s): section to 
       be repeated for (i) each type of instrument; 
       (ii) each type of transaction; (iii) each 
       date; and (iv) each place where transactions 
4.     have been conducted 
----  ----------------------------------------------------------------------- 
      Description 
       of the financial 
       instrument,                Shire plc American Depositary 
       type of instrument          Shares ("ADSs") 
---- 
      Identification 
a)     code                       ISIN: US82481R1068 
----  --------------------------  ------------------------------------------- 
                                  Receipt of ADSs following the 
                                   vesting of Performance Stock Units 
                                   ("PSUs") awarded under the Shire 
                                   Long Term Incentive Plan 2015 
                                   ("LTIP") on May 1, 2018. In accordance 
                                   with: 
                                   (i) the Co-Operation Agreement 
                                   between the Company and Takeda 
                                   Pharmaceutical Company Limited 
                                   dated May 8, 2018, and the rules 
                                   of the LTIP: 
                                   a. 100% of the PSUs vested pursuant 
                                   to applicable performance conditions; 
                                   b. vesting of the PSUs was accelerated 
                                   relative to the normal vesting 
                                   date; and 
                                   (ii) the rules of the LTIP, upon 
                                   vesting the number of ADSs to 
                                   be delivered was increased by 
                                   an amount equivalent to the value 
                                   of dividends paid by the Company 
                                   in respect of the PSUs from the 
                                   award date to the date of vesting. 
                                   (Details of related disposal of 
      Nature of the                ADSs are referenced in section 
b)     transaction                 5. below.) 
----  --------------------------  ------------------------------------------- 
                                         Price(s)              Volume(s) 
----  --------------------------  ----------------------  ------------------- 
      Price(s) and 
c)     volume(s)                   $                   0               12,050 
----  --------------------------      ------------------  ------------------- 
      Aggregated information 
       - Aggregated 
d)     volume - Price                                N/A (single transaction) 
----  --------------------------  ------------------------------------------- 
      Date of the 
e)     transaction                                          December 11, 2018 
----  --------------------------  ------------------------------------------- 
      Place of the 
f)     transaction                                                        N/A 
----  --------------------------  ------------------------------------------- 
      Details of the transaction(s): section to 
       be repeated for (i) each type of instrument; 
       (ii) each type of transaction; (iii) each 
       date; and (iv) each place where transactions 
5.     have been conducted 
----  ----------------------------------------------------------------------- 
      Description 
       of the financial 
       instrument,                              Shire plc American Depositary 
       type of instrument                                     Shares ("ADSs") 
---- 
      Identification 
a)     code                                                ISIN: US82481R1068 
----  --------------------------  ------------------------------------------- 
                                                Automated disposal of ADSs in 
                                              relation to the vesting of PSUs 
                                              referenced in section 4. above. 
                                                The proceeds of this disposal 
                                                were used to satisfy personal 
      Nature of the                          tax liabilities arising from the 
b)     transaction                                       vesting of the PSUs. 
----  --------------------------  ------------------------------------------- 
                                         Price(s)                   Volume(s) 
----  --------------------------  ----------------------  ------------------- 
      Price(s) and 
c)     volume(s)                   $            169.6625                5,420 
----  --------------------------      ------------------  ------------------- 
      Aggregated information 
       - Aggregated 
d)     volume - Price                                N/A (single transaction) 
----  --------------------------  ------------------------------------------- 
      Date of the 
e)     transaction                                          December 11, 2018 
----  --------------------------  ------------------------------------------- 
      Place of the 
f)     transaction                                                     NASDAQ 
----  --------------------------  ------------------------------------------- 
      Details of the transaction(s): section to 
       be repeated for (i) each type of instrument; 
       (ii) each type of transaction; (iii) each 
       date; and (iv) each place where transactions 
6.     have been conducted 
----  ----------------------------------------------------------------------- 
      Description 
       of the financial 
       instrument,                              Shire plc American Depositary 
       type of instrument                                     Shares ("ADSs") 
---- 
      Identification 
a)     code                                                ISIN: US82481R1068 
----  --------------------------  ------------------------------------------- 
                                                Receipt of ADSs following the 
                                           vesting of Performance Stock Units 
                                             ("PSUs") awarded under the Shire 
                                                Long Term Incentive Plan 2015 
                                               ("LTIP") on February 26, 2016. 
                                                          In accordance with: 
                                               (i) the Co-Operation Agreement 
                                               between the Company and Takeda 
                                               Pharmaceutical Company Limited 
                                             dated May 8, 2018, and the rules 
                                                                 of the LTIP: 
                                          a. 100% of the PSUs vested pursuant 
                                        to applicable performance conditions; 
                                       b. vesting of the PSUs was accelerated 
                                               relative to the normal vesting 
                                              date; and (ii) the rules of the 
                                                LTIP, upon vesting the number 
                                        of ADSs to be delivered was increased 
                                               by an amount equivalent to the 
                                               value of dividends paid by the 
                                               Company in respect of the PSUs 
                                              from the award date to the date 
                                                                  of vesting. 
                                              (Details of related disposal of 
      Nature of the                            ADSs are referenced in section 
b)     transaction                                                 7. below.) 
----  --------------------------  ------------------------------------------- 
                                         Price(s)                   Volume(s) 
----  --------------------------  ----------------------  ------------------- 
      Price(s) and 
c)     volume(s)                   $                   0                  494 
----  --------------------------      ------------------  ------------------- 
      Aggregated information 
       - Aggregated 
d)     volume - Price                                N/A (single transaction) 
----  --------------------------  ------------------------------------------- 
      Date of the 
e)     transaction                                          December 11, 2018 
----  --------------------------  ------------------------------------------- 
      Place of the 
f)     transaction                                                        N/A 
----  --------------------------  ------------------------------------------- 
      Details of the transaction(s): section to 
       be repeated for (i) each type of instrument; 
       (ii) each type of transaction; (iii) each 
       date; and (iv) each place where transactions 
7.     have been conducted 
----  ----------------------------------------------------------------------- 
      Description 
       of the financial 
       instrument,                              Shire plc American Depositary 
       type of instrument                                     Shares ("ADSs") 
---- 
      Identification 
a)     code                                                ISIN: US82481R1068 
----  --------------------------  ------------------------------------------- 
                                                Automated disposal of ADSs in 
                                              relation to the vesting of PSUs 
                                              referenced in section 6. above. 
                                                The proceeds of this disposal 
                                                were used to satisfy personal 
      Nature of the                          tax liabilities arising from the 
b)     transaction                                       vesting of the PSUs. 
----  --------------------------  ------------------------------------------- 
                                         Price(s)                   Volume(s) 
----  --------------------------  ----------------------  ------------------- 
      Price(s) and 
c)     volume(s)                   $            169.6625                  224 
----  --------------------------      ------------------  ------------------- 
      Aggregated information 
       - Aggregated 
d)     volume - Price                                N/A (single transaction) 
----  --------------------------  ------------------------------------------- 
      Date of the 
e)     transaction                                          December 11, 2018 
----  --------------------------  ------------------------------------------- 
      Place of the 
f)     transaction                                                     NASDAQ 
----  --------------------------  ------------------------------------------- 
      Details of the transaction(s): section to 
       be repeated for (i) each type of instrument; 
       (ii) each type of transaction; (iii) each 
       date; and (iv) each place where transactions 
8.     have been conducted 
----  ----------------------------------------------------------------------- 
      Description 
       of the financial 
       instrument,                              Shire plc American Depositary 
       type of instrument                                     Shares ("ADSs") 
---- 
      Identification 
a)     code                                                ISIN: US82481R1068 
----  --------------------------  ------------------------------------------- 
                                                Receipt of ADSs following the 
                                            vesting of Restricted Stock Units 
                                             ("RSUs") awarded under the Shire 
                                                Long Term Incentive Plan 2015 
                                              ("LTIP") on August 24, 2017. In 
                                                             accordance with: 
                                               (i) the Co-Operation Agreement 
                                               between the Company and Takeda 
                                               Pharmaceutical Company Limited 
                                             dated May 8, 2018, and the rules 
                                             of the LTIP, vesting of the RSUs 
                                              was accelerated relative to the 
                                                normal vesting date; and (ii) 
                                          the rules of the LTIP, upon vesting 
                                           the number of ADSs to be delivered 
                                        was increased by an amount equivalent 
                                               to the value of dividends paid 
                                             by the Company in respect of the 
                                              RSUs from the award date to the 
                                                             date of vesting. 
                                              (Details of related disposal of 
      Nature of the                            ADSs are referenced in section 
b)     transaction                                                 9. below.) 
----  --------------------------  ------------------------------------------- 
                                         Price(s)                   Volume(s) 
----  --------------------------  ----------------------  ------------------- 
      Price(s) and 
c)     volume(s)                   $                   0                1,410 
----  --------------------------      ------------------  ------------------- 
      Aggregated information 
       - Aggregated 
d)     volume - Price                                N/A (single transaction) 
----  --------------------------  ------------------------------------------- 
      Date of the 
e)     transaction                                          December 11, 2018 
----  --------------------------  ------------------------------------------- 
      Place of the 
f)     transaction                                                        N/A 
----  --------------------------  ------------------------------------------- 
      Details of the transaction(s): section to 
       be repeated for (i) each type of instrument; 
       (ii) each type of transaction; (iii) each 
       date; and (iv) each place where transactions 
9.     have been conducted 
----  ----------------------------------------------------------------------- 
      Description 
       of the financial 
       instrument,                              Shire plc American Depositary 
       type of instrument                                     Shares ("ADSs") 
---- 
      Identification 
a)     code                                                ISIN: US82481R1068 
----  --------------------------  ------------------------------------------- 
                                                Automated disposal of ADSs in 
                                              relation to the vesting of RSUs 
                                              referenced in section 8. above. 
                                                The proceeds of this disposal 
                                                were used to satisfy personal 
      Nature of the                          tax liabilities arising from the 
b)     transaction                                       vesting of the RSUs. 
----  --------------------------  ------------------------------------------- 
                                         Price(s)                   Volume(s) 
----  --------------------------  ----------------------  ------------------- 
      Price(s) and 
c)     volume(s)                   $            169.6625                  633 
----  --------------------------      ------------------  ------------------- 
      Aggregated information 
       - Aggregated 
d)     volume - Price                                N/A (single transaction) 
----  --------------------------  ------------------------------------------- 
      Date of the 
e)     transaction                                          December 11, 2018 
----  --------------------------  ------------------------------------------- 
      Place of the 
f)     transaction                                                     NASDAQ 
----  --------------------------  ------------------------------------------- 
      Details of the transaction(s): section to 
       be repeated for (i) each type of instrument; 
       (ii) each type of transaction; (iii) each 
       date; and (iv) each place where transactions 
10.    have been conducted 
----  ----------------------------------------------------------------------- 
      Description 
       of the financial 
       instrument,                              Shire plc American Depositary 
       type of instrument                                     Shares ("ADSs") 
---- 
      Identification 
a)     code                                                ISIN: US82481R1068 
----  --------------------------  ------------------------------------------- 
                                                Receipt of ADSs following the 
                                            vesting of Restricted Stock Units 
                                             ("RSUs") awarded under the Shire 
                                                Long Term Incentive Plan 2015 
                                               ("LTIP") on February 28, 2017. 
                                                          In accordance with: 
                                               (i) the Co-Operation Agreement 
                                               between the Company and Takeda 
                                               Pharmaceutical Company Limited 
                                             dated May 8, 2018, and the rules 
                                             of the LTIP, vesting of the RSUs 
                                              was accelerated relative to the 
                                                normal vesting date; and (ii) 
                                          the rules of the LTIP, upon vesting 
                                           the number of ADSs to be delivered 
                                        was increased by an amount equivalent 
                                               to the value of dividends paid 
                                             by the Company in respect of the 
                                              RSUs from the award date to the 
                                                             date of vesting. 
                                              (Details of related disposal of 
      Nature of the                            ADSs are referenced in section 
b)     transaction                                                11. below.) 
----  --------------------------  ------------------------------------------- 
                                         Price(s)                   Volume(s) 
----  --------------------------  ----------------------  ------------------- 
      Price(s) and 
c)     volume(s)                   $                   0                  104 
----  --------------------------      ------------------  ------------------- 
      Aggregated information 
       - Aggregated 
d)     volume - Price                                N/A (single transaction) 
----  --------------------------  ------------------------------------------- 
      Date of the 
e)     transaction                                          December 11, 2018 
----  --------------------------  ------------------------------------------- 
      Place of the 
f)     transaction                                                        N/A 
----  --------------------------  ------------------------------------------- 
      Details of the transaction(s): section to 
       be repeated for (i) each type of instrument; 
       (ii) each type of transaction; (iii) each 
       date; and (iv) each place where transactions 
11.    have been conducted 
----  ----------------------------------------------------------------------- 
      Description 
       of the financial 
       instrument,                              Shire plc American Depositary 
       type of instrument                                     Shares ("ADSs") 
---- 
      Identification 
a)     code                                                ISIN: US82481R1068 
----  --------------------------  ------------------------------------------- 
                                                Automated disposal of ADSs in 
                                              relation to the vesting of RSUs 
                                             referenced in section 10. above. 
                                                The proceeds of this disposal 
                                                were used to satisfy personal 
      Nature of the                          tax liabilities arising from the 
b)     transaction                                       vesting of the RSUs. 
----  --------------------------  ------------------------------------------- 
                                         Price(s)                   Volume(s) 
----  --------------------------  ----------------------  ------------------- 
      Price(s) and 
c)     volume(s)                   $            169.6625                   47 
----  --------------------------      ------------------  ------------------- 
      Aggregated information 
       - Aggregated 
d)     volume - Price                                N/A (single transaction) 
----  --------------------------  ------------------------------------------- 
      Date of the 
e)     transaction                                          December 11, 2018 
----  --------------------------  ------------------------------------------- 
      Place of the 
f)     transaction                                                     NASDAQ 
----  --------------------------  ------------------------------------------- 
      Details of the transaction(s): section to 
       be repeated for (i) each type of instrument; 
       (ii) each type of transaction; (iii) each 
       date; and (iv) each place where transactions 
12.    have been conducted 
----  ----------------------------------------------------------------------- 
      Description 
       of the financial 
       instrument,                              Shire plc American Depositary 
       type of instrument                                     Shares ("ADSs") 
---- 
      Identification 
a)     code                                                ISIN: US82481R1068 
----  --------------------------  ------------------------------------------- 
                                                Receipt of ADSs following the 
                                            vesting of Restricted Stock Units 
                                             ("RSUs") awarded under the Shire 
                                                Long Term Incentive Plan 2015 
                                               ("LTIP") on February 26, 2016. 
                                                          In accordance with: 
                                               (i) the Co-Operation Agreement 
                                               between the Company and Takeda 
                                               Pharmaceutical Company Limited 
                                             dated May 8, 2018, and the rules 
                                             of the LTIP, vesting of the RSUs 
                                              was accelerated relative to the 
                                                normal vesting date; and (ii) 
                                          the rules of the LTIP, upon vesting 
                                           the number of ADSs to be delivered 
                                        was increased by an amount equivalent 
                                               to the value of dividends paid 
                                             by the Company in respect of the 
                                              RSUs from the award date to the 
                                                             date of vesting. 
                                              (Details of related disposal of 
      Nature of the                            ADSs are referenced in section 
b)     transaction                                                13. below.) 
----  --------------------------  ------------------------------------------- 
                                         Price(s)                   Volume(s) 
----  --------------------------  ----------------------  ------------------- 
      Price(s) and 
c)     volume(s)                   $                   0                  173 
----  --------------------------      ------------------  ------------------- 
      Aggregated information 
       - Aggregated 
d)     volume - Price                                N/A (single transaction) 
----  --------------------------  ------------------------------------------- 
      Date of the 
e)     transaction                                          December 11, 2018 
----  --------------------------  ------------------------------------------- 
      Place of the 
f)     transaction                                                        N/A 
----  --------------------------  ------------------------------------------- 
      Details of the transaction(s): section to 
       be repeated for (i) each type of instrument; 
       (ii) each type of transaction; (iii) each 
       date; and (iv) each place where transactions 
13.    have been conducted 
----  ----------------------------------------------------------------------- 
      Description 
       of the financial 
       instrument,                              Shire plc American Depositary 
       type of instrument                                     Shares ("ADSs") 
---- 
      Identification 
a)     code                                                ISIN: US82481R1068 
----  --------------------------  ------------------------------------------- 
                                                Automated disposal of ADSs in 
                                              relation to the vesting of RSUs 
                                             referenced in section 12. above. 
                                                The proceeds of this disposal 
                                                were used to satisfy personal 
      Nature of the                          tax liabilities arising from the 
b)     transaction                                       vesting of the RSUs. 
----  --------------------------  ------------------------------------------- 
                                         Price(s)                   Volume(s) 
----  --------------------------  ----------------------  ------------------- 
      Price(s) and 
c)     volume(s)                   $            169.6625                   79 
----  --------------------------      ------------------  ------------------- 
d)    Aggregated information      N/A (single transaction) 
       - Aggregated 
       volume - Price 
----  --------------------------  ------------------------------------------- 
e)    Date of the                 December 11, 2018 
       transaction 
----  --------------------------  ------------------------------------------- 
f)    Place of the                NASDAQ 
       transaction 
----  --------------------------  ------------------------------------------- 
 
 
 
 
 
 
      Details of the person discharging managerial 
       responsibilities ("PDMR") / person closely 
1.     associated with them ("PCA") 
----  ----------------------------------------------------------------------- 
a)    Name                        Perry Sternberg 
----  --------------------------  ------------------------------------------- 
2.    Reason for the notification 
----  ----------------------------------------------------------------------- 
a)    Position / status           Head of US Commercial - PDMR 
----  --------------------------  ------------------------------------------- 
      Initial notification 
b)     / amendment                Initial notification 
----  --------------------------  ------------------------------------------- 
      Details of the issuer, emission allowance 
       participant, auction platform, auctioneer 
3.     or auction monitor 
----  ----------------------------------------------------------------------- 
a)    Name                        Shire plc 
----  --------------------------  ------------------------------------------- 
b)    LEI                         54930005LQRLI2UXRQ59 
----  --------------------------  ------------------------------------------- 
      Details of the transaction(s): section to 
       be repeated for (i) each type of instrument; 
       (ii) each type of transaction; (iii) each 
       date; and (iv) each place where transactions 
4.     have been conducted 
----  ----------------------------------------------------------------------- 
      Description 
       of the financial 
       instrument,                Shire plc American Depositary 
       type of instrument          Shares ("ADSs") 
---- 
      Identification 
a)     code                       ISIN: US82481R1068 
----  --------------------------  ------------------------------------------- 
                                  Receipt of ADSs following the 
                                   vesting of Restricted Stock Units 
                                   ("RSUs") awarded under the Shire 
                                   Long Term Incentive Plan 2015 
                                   ("LTIP") on August 5, 2016. In 
                                   accordance with: 
                                   (i) the Co-Operation Agreement 
                                   between the Company and Takeda 
                                   Pharmaceutical Company Limited 
                                   dated May 8, 2018, and the rules 
                                   of the LTIP, vesting of the RSUs 
                                   was accelerated relative to the 
                                   normal vesting date; and (ii) 
                                   the rules of the LTIP, upon vesting 
                                   the number of ADSs to be delivered 
                                   was increased by an amount equivalent 
                                   to the value of dividends paid 
                                   by the Company in respect of the 
                                   RSUs from the award date to the 
                                   date of vesting. 
                                   (Details of related disposal of 
      Nature of the                ADSs are referenced in section 
b)     transaction                 5. below.) 
----  --------------------------  ------------------------------------------- 
                                         Price(s)              Volume(s) 
----  --------------------------  ----------------------  ------------------- 
      Price(s) and 
c)     volume(s)                   $                   0                1,011 
----  --------------------------      ------------------  ------------------- 
      Aggregated information 
       - Aggregated 
d)     volume - Price                                N/A (single transaction) 
----  --------------------------  ------------------------------------------- 
      Date of the 
e)     transaction                                          December 11, 2018 
----  --------------------------  ------------------------------------------- 
      Place of the 
f)     transaction                                                        N/A 
----  --------------------------  ------------------------------------------- 
      Details of the transaction(s): section to 
       be repeated for (i) each type of instrument; 
       (ii) each type of transaction; (iii) each 
       date; and (iv) each place where transactions 
5.     have been conducted 
----  ----------------------------------------------------------------------- 
      Description 
       of the financial 
       instrument,                              Shire plc American Depositary 
       type of instrument                                     Shares ("ADSs") 
---- 
      Identification 
a)     code                                                ISIN: US82481R1068 
----  --------------------------  ------------------------------------------- 
                                                Automated disposal of ADSs in 
                                              relation to the vesting of RSUs 
                                              referenced in section 4. above. 
                                                The proceeds of this disposal 
                                                were used to satisfy personal 
      Nature of the                          tax liabilities arising from the 
b)     transaction                                       vesting of the RSUs. 
----  --------------------------  ------------------------------------------- 
                                         Price(s)                   Volume(s) 
----  --------------------------  ----------------------  ------------------- 
      Price(s) and 
c)     volume(s)                   $            169.6625                  388 
----  --------------------------      ------------------  ------------------- 
      Aggregated information 
       - Aggregated 
d)     volume - Price                                N/A (single transaction) 
----  --------------------------  ------------------------------------------- 
      Date of the 
e)     transaction                                          December 11, 2018 
----  --------------------------  ------------------------------------------- 
      Place of the 
f)     transaction                                                     NASDAQ 
----  --------------------------  ------------------------------------------- 
      Details of the transaction(s): section to 
       be repeated for (i) each type of instrument; 
       (ii) each type of transaction; (iii) each 
       date; and (iv) each place where transactions 
6.     have been conducted 
----  ----------------------------------------------------------------------- 
      Description 
       of the financial 
       instrument,                              Shire plc American Depositary 
       type of instrument                                     Shares ("ADSs") 
---- 
      Identification 
a)     code                                                ISIN: US82481R1068 
----  --------------------------  ------------------------------------------- 
                                                Receipt of ADSs following the 
                                            vesting of Restricted Stock Units 
                                             ("RSUs") awarded under the Shire 
                                                Long Term Incentive Plan 2015 
                                               ("LTIP") on February 26, 2016. 
                                                          In accordance with: 
                                               (i) the Co-Operation Agreement 
                                               between the Company and Takeda 
                                               Pharmaceutical Company Limited 
                                             dated May 8, 2018, and the rules 
                                             of the LTIP, vesting of the RSUs 
                                              was accelerated relative to the 
                                                normal vesting date; and (ii) 
                                          the rules of the LTIP, upon vesting 
                                           the number of ADSs to be delivered 
                                        was increased by an amount equivalent 
                                               to the value of dividends paid 
                                             by the Company in respect of the 
                                              RSUs from the award date to the 
                                                             date of vesting. 
                                              (Details of related disposal of 
      Nature of the                            ADSs are referenced in section 
b)     transaction                                                 7. below.) 
----  --------------------------  ------------------------------------------- 
                                         Price(s)                   Volume(s) 
----  --------------------------  ----------------------  ------------------- 
      Price(s) and 
c)     volume(s)                   $                   0                  441 
----  --------------------------      ------------------  ------------------- 
      Aggregated information 
       - Aggregated 
d)     volume - Price                                N/A (single transaction) 
----  --------------------------  ------------------------------------------- 
      Date of the 
e)     transaction                                          December 11, 2018 
----  --------------------------  ------------------------------------------- 
      Place of the 
f)     transaction                                                        N/A 
----  --------------------------  ------------------------------------------- 
      Details of the transaction(s): section to 
       be repeated for (i) each type of instrument; 
       (ii) each type of transaction; (iii) each 
       date; and (iv) each place where transactions 
7.     have been conducted 
----  ----------------------------------------------------------------------- 
      Description 
       of the financial 
       instrument,                              Shire plc American Depositary 
       type of instrument                                     Shares ("ADSs") 
---- 
      Identification 
a)     code                                                ISIN: US82481R1068 
----  --------------------------  ------------------------------------------- 
                                                Automated disposal of ADSs in 
                                              relation to the vesting of RSUs 
                                              referenced in section 6. above. 
                                                The proceeds of this disposal 
                                                were used to satisfy personal 
      Nature of the                          tax liabilities arising from the 
b)     transaction                                       vesting of the RSUs. 
----  --------------------------  ------------------------------------------- 
                                         Price(s)                   Volume(s) 
----  --------------------------  ----------------------  ------------------- 
      Price(s) and 
c)     volume(s)                   $            169.6625                  133 
----  --------------------------      ------------------  ------------------- 
      Aggregated information 
       - Aggregated 
d)     volume - Price                                N/A (single transaction) 
----  --------------------------  ------------------------------------------- 
      Date of the 
e)     transaction                                          December 11, 2018 
----  --------------------------  ------------------------------------------- 
      Place of the 
f)     transaction                                                     NASDAQ 
----  --------------------------  ------------------------------------------- 
      Details of the transaction(s): section to 
       be repeated for (i) each type of instrument; 
       (ii) each type of transaction; (iii) each 
       date; and (iv) each place where transactions 
8.     have been conducted 
----  ----------------------------------------------------------------------- 
      Description 
       of the financial 
       instrument,                              Shire plc American Depositary 
       type of instrument                                     Shares ("ADSs") 
---- 
      Identification 
a)     code                                                ISIN: US82481R1068 
----  --------------------------  ------------------------------------------- 
                                                Receipt of ADSs following the 
                                           vesting of Performance Stock Units 
                                             ("PSUs") awarded under the Shire 
                                                Long Term Incentive Plan 2015 
                                               ("LTIP") on February 26, 2016. 
                                                          In accordance with: 
                                               (i) the Co-Operation Agreement 
                                               between the Company and Takeda 
                                               Pharmaceutical Company Limited 
                                             dated May 8, 2018, and the rules 
                                                                 of the LTIP: 
                                          a. 100% of the PSUs vested pursuant 
                                        to applicable performance conditions; 
                                       b. vesting of the PSUs was accelerated 
                                               relative to the normal vesting 
                                                                    date; and 
                                             (ii) the rules of the LTIP, upon 
                                                vesting the number of ADSs to 
                                                be delivered was increased by 
                                            an amount equivalent to the value 
                                             of dividends paid by the Company 
                                              in respect of the PSUs from the 
                                           award date to the date of vesting. 
                                                (Details of related disposals 
      Nature of the                        of ADSs are referenced in sections 
b)     transaction                                        10. and 11. below.) 
----  --------------------------  ------------------------------------------- 
                                         Price(s)                   Volume(s) 
----  --------------------------  ----------------------  ------------------- 
      Price(s) and 
c)     volume(s)                   $                   0                1,260 
----  --------------------------      ------------------  ------------------- 
      Aggregated information 
       - Aggregated 
d)     volume - Price                                N/A (single transaction) 
----  --------------------------  ------------------------------------------- 
      Date of the 
e)     transaction                                          December 11, 2018 
----  --------------------------  ------------------------------------------- 
      Place of the 
f)     transaction                                                        N/A 
----  --------------------------  ------------------------------------------- 
      Details of the transaction(s): section to 
       be repeated for (i) each type of instrument; 
       (ii) each type of transaction; (iii) each 
       date; and (iv) each place where transactions 
9.     have been conducted 
----  ----------------------------------------------------------------------- 
      Description 
       of the financial 
       instrument,                              Shire plc American Depositary 
       type of instrument                                     Shares ("ADSs") 
---- 
      Identification 
a)     code                                                ISIN: US82481R1068 
----  --------------------------  ------------------------------------------- 
                                                Receipt of ADSs following the 
                                           vesting of Performance Stock Units 
                                             ("PSUs") awarded under the Shire 
                                                Long Term Incentive Plan 2015 
                                               ("LTIP") on February 28, 2017. 
                                                          In accordance with: 
                                               (i) the Co-Operation Agreement 
                                               between the Company and Takeda 
                                               Pharmaceutical Company Limited 
                                             dated May 8, 2018, and the rules 
                                                                 of the LTIP: 
                                           a. 87% of the PSUs vested pursuant 
                                        to applicable performance conditions; 
                                       b. vesting of the PSUs was accelerated 
                                               relative to the normal vesting 
                                                                    date; and 
                                             (ii) the rules of the LTIP, upon 
                                                vesting the number of ADSs to 
                                                be delivered was increased by 
                                            an amount equivalent to the value 
                                             of dividends paid by the Company 
                                              in respect of the PSUs from the 
                                           award date to the date of vesting. 
                                                (Details of related disposals 
      Nature of the                        of ADSs are referenced in sections 
b)     transaction                                        10. and 11. below.) 
----  --------------------------  ------------------------------------------- 
                                         Price(s)                   Volume(s) 
----  --------------------------  ----------------------  ------------------- 
      Price(s) and 
c)     volume(s)                   $                   0                7,790 
----  --------------------------      ------------------  ------------------- 
      Aggregated information 
       - Aggregated 
d)     volume - Price                                N/A (single transaction) 
----  --------------------------  ------------------------------------------- 
      Date of the 
e)     transaction                                          December 11, 2018 
----  --------------------------  ------------------------------------------- 
      Place of the 
f)     transaction                                                        N/A 
----  --------------------------  ------------------------------------------- 
      Details of the transaction(s): section to 
       be repeated for (i) each type of instrument; 
       (ii) each type of transaction; (iii) each 
       date; and (iv) each place where transactions 
10.    have been conducted 
----  ----------------------------------------------------------------------- 
      Description 
       of the financial 
       instrument,                              Shire plc American Depositary 
       type of instrument                                     Shares ("ADSs") 
---- 
      Identification 
a)     code                                                ISIN: US82481R1068 
----  --------------------------  ------------------------------------------- 
                                                Automated disposal of ADSs in 
                                              relation to the vesting of PSUs 
                                              referenced in sections 8 and 9. 
                                         above. The proceeds of this disposal 
                                                were used to satisfy personal 
      Nature of the                          tax liabilities arising from the 
b)     transaction                                       vesting of the PSUs. 
----  --------------------------  ------------------------------------------- 
                                         Price(s)                   Volume(s) 
----  --------------------------  ----------------------  ------------------- 
      Price(s) and 
c)     volume(s)                   $            169.6625                3,940 
----  --------------------------      ------------------  ------------------- 
      Aggregated information 
       - Aggregated 
d)     volume - Price                                N/A (single transaction) 
----  --------------------------  ------------------------------------------- 
      Date of the 
e)     transaction                                          December 11, 2018 
----  --------------------------  ------------------------------------------- 
      Place of the 
f)     transaction                                                     NASDAQ 
----  --------------------------  ------------------------------------------- 
      Details of the transaction(s): section to 
       be repeated for (i) each type of instrument; 
       (ii) each type of transaction; (iii) each 
       date; and (iv) each place where transactions 
11.    have been conducted 
----  ----------------------------------------------------------------------- 
      Description 
       of the financial 
       instrument,                              Shire plc American Depositary 
       type of instrument                                     Shares ("ADSs") 
---- 
      Identification 
a)     code                                                ISIN: US82481R1068 
----  --------------------------  ------------------------------------------- 
                                                Automated disposal of ADSs in 
                                              relation to the vesting of PSUs 
                                                referenced in sections 8. and 
                                               9. above. The proceeds of this 
                                                disposal were used to satisfy 
      Nature of the                          personal tax liabilities arising 
b)     transaction                              from the vesting of the PSUs. 
----  --------------------------  ------------------------------------------- 
                                         Price(s)                   Volume(s) 
----  --------------------------  ----------------------  ------------------- 
      Price(s) and 
c)     volume(s)                   $            175.1500                   91 
----  --------------------------      ------------------  ------------------- 
d)    Aggregated information      N/A (single transaction) 
       - Aggregated 
       volume - Price 
----  --------------------------  ------------------------------------------- 
e)    Date of the                 December 13, 2018 
       transaction 
----  --------------------------  ------------------------------------------- 
f)    Place of the                NASDAQ 
       transaction 
----  --------------------------  ------------------------------------------- 
 
 
 
 
 
 
     Details of the person discharging managerial 
      responsibilities ("PDMR") / person closely 
1.    associated with them ("PCA") 
---  ----------------------------------------------------------------------- 
a)   Name                        Matt Walker 
---  --------------------------  ------------------------------------------- 
2.   Reason for the notification 
---  ----------------------------------------------------------------------- 
                                 Head of Technical Operations -- 
a)   Position / status            PDMR 
---  --------------------------  ------------------------------------------- 
     Initial notification 
b)    / amendment                Initial notification 
---  --------------------------  ------------------------------------------- 
     Details of the issuer, emission allowance 
      participant, auction platform, auctioneer 
3.    or auction monitor 
---  ----------------------------------------------------------------------- 
a)   Name                        Shire plc 
---  --------------------------  ------------------------------------------- 
b)   LEI                         54930005LQRLI2UXRQ59 
---  --------------------------  ------------------------------------------- 
     Details of the transaction(s): section to 
      be repeated for (i) each type of instrument; 
      (ii) each type of transaction; (iii) each 
      date; and (iv) each place where transactions 
4.    have been conducted 
---  ----------------------------------------------------------------------- 
     Description 
      of the financial 
      instrument,                Shire plc American Depositary 
      type of instrument          Shares ("ADSs") 
--- 
     Identification 
a)    code                       ISIN: US82481R1068 
---  --------------------------  ------------------------------------------- 
                                 Receipt of ADSs following the 
                                  vesting of Performance Stock Units 
                                  ("PSUs") awarded under the Shire 
                                  Long Term Incentive Plan 2015 
                                  ("LTIP") on May 1, 2018. In accordance 
                                  with: 
                                  (i) the Co-Operation Agreement 
                                  between the Company and Takeda 
                                  Pharmaceutical Company Limited 
                                  dated May 8, 2018, and the rules 
                                  of the LTIP: 
                                  a. 100% of the PSUs vested pursuant 
                                  to applicable performance conditions; 
                                  b. vesting of the PSUs was accelerated 
                                  relative to the normal vesting 
                                  date; and 
                                  (ii) the rules of the LTIP, upon 
                                  vesting the number of ADSs to 
                                  be delivered was increased by 
                                  an amount equivalent to the value 
                                  of dividends paid by the Company 
                                  in respect of the PSUs from the 
                                  award date to the date of vesting. 
                                  (Details of related disposal of 
     Nature of the                ADSs are referenced in section 
b)    transaction                 5. below.) 
---  --------------------------  ------------------------------------------- 
                                        Price(s)              Volume(s) 
---  --------------------------  ----------------------  ------------------- 
     Price(s) and 
c)    volume(s)                   $                   0               12,665 
---  --------------------------      ------------------  ------------------- 
     Aggregated information 
      - Aggregated 
d)    volume - Price                                N/A (single transaction) 
---  --------------------------  ------------------------------------------- 
     Date of the 
e)    transaction                                          December 11, 2018 
---  --------------------------  ------------------------------------------- 
     Place of the 
f)    transaction                                                        N/A 
---  --------------------------  ------------------------------------------- 
     Details of the transaction(s): section to 
      be repeated for (i) each type of instrument; 
      (ii) each type of transaction; (iii) each 
      date; and (iv) each place where transactions 
5.    have been conducted 
---  ----------------------------------------------------------------------- 
     Description 
      of the financial 
      instrument,                              Shire plc American Depositary 
      type of instrument                                     Shares ("ADSs") 
--- 
     Identification 
a)    code                                                ISIN: US82481R1068 
---  --------------------------  ------------------------------------------- 
                                               Automated disposal of ADSs in 
                                             relation to the vesting of PSUs 
                                             referenced in section 4. above. 
                                               The proceeds of this disposal 
                                               were used to satisfy personal 
     Nature of the                          tax liabilities arising from the 
b)    transaction                                       vesting of the PSUs. 
---  --------------------------  ------------------------------------------- 
                                        Price(s)                   Volume(s) 
---  --------------------------  ----------------------  ------------------- 
     Price(s) and 
c)    volume(s)                   $            169.6625                5,652 
---  --------------------------      ------------------  ------------------- 
     Aggregated information 
      - Aggregated 
d)    volume - Price                                N/A (single transaction) 
---  --------------------------  ------------------------------------------- 
     Date of the 
e)    transaction                                          December 11, 2018 
---  --------------------------  ------------------------------------------- 
     Place of the 
f)    transaction                                                     NASDAQ 
---  --------------------------  ------------------------------------------- 
     Details of the transaction(s): section to 
      be repeated for (i) each type of instrument; 
      (ii) each type of transaction; (iii) each 
      date; and (iv) each place where transactions 
6.    have been conducted 
---  ----------------------------------------------------------------------- 
     Description 
      of the financial 
      instrument,                              Shire plc American Depositary 
      type of instrument                                     Shares ("ADSs") 
--- 
     Identification 
a)    code                                                ISIN: US82481R1068 
---  --------------------------  ------------------------------------------- 
                                               Receipt of ADSs following the 
                                          vesting of Performance Stock Units 
                                            ("PSUs") awarded under the Shire 
                                               Long Term Incentive Plan 2015 
                                      ("LTIP") on May 2, 2016. In accordance 
                                                                       with: 
                                              (i) the Co-Operation Agreement 
                                              between the Company and Takeda 
                                              Pharmaceutical Company Limited 
                                            dated May 8, 2018, and the rules 
                                                                of the LTIP: 
                                         a. 100% of the PSUs vested pursuant 
                                       to applicable performance conditions; 
                                      b. vesting of the PSUs was accelerated 
                                              relative to the normal vesting 
                                                                   date; and 
                                            (ii) the rules of the LTIP, upon 
                                               vesting the number of ADSs to 
                                               be delivered was increased by 
                                           an amount equivalent to the value 
                                            of dividends paid by the Company 
                                             in respect of the PSUs from the 
                                          award date to the date of vesting. 
                                             (Details of related disposal of 
     Nature of the                            ADSs are referenced in section 
b)    transaction                                                 7. below.) 
---  --------------------------  ------------------------------------------- 
                                        Price(s)                   Volume(s) 
---  --------------------------  ----------------------  ------------------- 
     Price(s) and 
c)    volume(s)                   $                   0                3,292 
---  --------------------------      ------------------  ------------------- 
     Aggregated information 
      - Aggregated 
d)    volume - Price                                N/A (single transaction) 
---  --------------------------  ------------------------------------------- 
     Date of the 
e)    transaction                                          December 11, 2018 
---  --------------------------  ------------------------------------------- 
     Place of the 
f)    transaction                                                        N/A 
---  --------------------------  ------------------------------------------- 
     Details of the transaction(s): section to 
      be repeated for (i) each type of instrument; 
      (ii) each type of transaction; (iii) each 
      date; and (iv) each place where transactions 
7.    have been conducted 
---  ----------------------------------------------------------------------- 
     Description 
      of the financial 
      instrument,                              Shire plc American Depositary 
      type of instrument                                     Shares ("ADSs") 
--- 
     Identification 
a)    code                                                ISIN: US82481R1068 
---  --------------------------  ------------------------------------------- 
                                               Automated disposal of ADSs in 
                                             relation to the vesting of PSUs 
                                             referenced in section 6. above. 
                                               The proceeds of this disposal 
                                               were used to satisfy personal 
     Nature of the                          tax liabilities arising from the 
b)    transaction                                       vesting of the PSUs. 
---  --------------------------  ------------------------------------------- 
                                        Price(s)                   Volume(s) 
---  --------------------------  ----------------------  ------------------- 
     Price(s) and 
c)    volume(s)                   $            169.6625                  983 
---  --------------------------      ------------------  ------------------- 
d)   Aggregated information      N/A (single transaction) 
      - Aggregated 
      volume - Price 
---  --------------------------  ------------------------------------------- 
e)   Date of the                 December 11, 2018 
      transaction 
---  --------------------------  ------------------------------------------- 
f)   Place of the                NASDAQ 
      transaction 
---  --------------------------  ------------------------------------------- 
 
   Oliver Strawbridge 
 
   Senior Assistant Company Secretary 
 
   For further information please contact: 
 
 
 
 
Investor Relations 
Christoph Brackmann   christoph.brackmann@shire.com   +41 41 288 41 29 
Sun Kim               sun.kim@shire.com                +1 617 588 8175 
Scott Burrows         scott.burrows@shire.com          +41 41 288 4195 
 
Media 
Katie Joyce           kjoyce@shire.com                 +1 781 482 2779 
 
 
 
   NOTES TO EDITORS 
 
   About Shire 
 
   Shire is the global biotechnology leader serving patients with rare 
diseases and specialized conditions. We seek to push boundaries through 
discovering and delivering new possibilities for patient communities who 
often have few or no other champions. Relentlessly on the edge of what's 
next, we are serial innovators with a diverse pipeline offering fresh 
thinking and new hope. Serving patients and partnering with healthcare 
communities in over 100 countries, we strive to be part of the entire 
patient journey to enable earlier diagnosis, raise standards of care, 
accelerate access to treatment, and support patients. Our diverse 
portfolio of therapeutic areas includes Immunology, Hematology, Genetic 
Diseases, Neuroscience, Internal Medicine, and Ophthalmics. 
 
 
 
   Championing patients is our call to action - it brings the opportunity - 
and responsibility - to change people's lives. 
 
   www.shire.com 
 
 
 
 

(END) Dow Jones Newswires

December 14, 2018 08:15 ET (13:15 GMT)

Copyright (c) 2018 Dow Jones & Company, Inc.
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