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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

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FORM 6-K

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REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934

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For the month of October, 2022

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Commission file number: 001-37891

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AC IMMUNE SA

(Exact Name of Registrant as Specified in Its Charter)

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EPFL Innovation Park

Building B

1015 Lausanne, Switzerland

(Address of Principal Executive Offices)

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Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F.

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Form 20-F ☒     Form 40-F ☐

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Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1):

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Yes ☐     No ☒

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Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7):

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Yes ☐     No ☒

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This Report on Form 6-K (excluding Exhibit 99.3 herewith) is incorporated by reference into the Registrant’s registration statement on Form F-3 (File Nos. 333-227016, 333-249655 and 333-255576) and Form S-8 (File No. 333-233019).

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SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

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AC IMMUNE SA

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By:

/s/ Andrea Pfeifer

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Name:  Andrea Pfeifer

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Title:    Chief Executive Officer

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By:

/s/ Christopher Roberts

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Name:  Christopher Roberts

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Title:    Vice President Finance and interim Chief Financial Officer

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Date:     October 28, 2022

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