Master Fund L.P. is c/o Matrix Capital Management L.P., Bay Colony Corporate Center, 1000 Winter Street, Suite 4500, Waltham, MA 02451.
(2)
Beneficial ownership consists of (i) 82,978,668 ordinary shares represented by 13,829,778 ADSs directly held by New Enterprise Associates 14, L.P., or NEA 14; (ii) 19,500,000 ordinary shares represented by 3,250,000 ADSs directly held by New Enterprise Associates 16, L.P., or NEA 16; and (iii) 16,998 ordinary shares represented by 2,833 ADSs directly held by NEA Ventures 2014, L.P., or NEA Ven 2014. The shares directly held by NEA 14 are indirectly held by NEA Partners 14, L.P., or NEA Partners 14, the sole general partner of NEA 14, NEA 14 GP, LTD, or NEA 14 LTD, the sole general partner of NEA Partners 14 and each of the individual Directors of NEA 14 LTD. The individual Directors, or collectively, the Directors of NEA 14 LTD, are Forest Baskett, Anthony A. Florence, Jr., Patrick J. Kerins, Scott D. Sandell and Peter W. Sonsini. The shares directly held by NEA 16 are indirectly held by NEA Partners 16, L.P., or NEA Partners 16, the sole general partner of NEA 16, NEA 16 GP, LLC, or NEA 16 LLC, the sole general partner of NEA Partners 16 and each of the individual Managers of NEA 16 LLC. The individual Managers of NEA 16 LLC, or collectively, the NEA 16 Managers, are Forest Baskett, Ali Behbahani (a member of our Board), Carmen Chang, Anthony A. Florence, Jr., Mohamad H. Makhzoumi, Scott D. Sandell, Peter W. Sonsini and Paul Walker. The shares directly held by NEA Ven 2014 are indirectly held by Karen P. Welsh, the general partner of NEA Ven 2014. All indirect holders of the above referenced shares disclaim beneficial ownership of all applicable shares except to the extent of their actual pecuniary interest therein. The principal business address of New Enterprise Associates, Inc. is 1954 Greenspring Drive, Suite 600, Timonium, MD 21093.
(3)
Consists of shares held as of December 31, 2021 based on information provided in a Schedule 13G/A filed with the SEC on January 17, 2022. Baillie Gifford & Co and/or entities affiliated with Baillie
Gifford & Co holds these shares in the form of ADSs. The business address of Baillie Gifford & Co is Calton Square, 1 Greenside Row, Edinburgh EH1 34N, Scotland, UK.
(4)
Consists of shares held as of December 31, 2020 based on information provided in a Schedule 13G filed with the SEC on February 16, 2021. The Reporting Persons are the Baker Bros. Advisors L.P., Baker Bros. Advisors (GP) LLC, Felix J. Baker and Julian C. Baker. Beneficial ownership consists of (i) 54,419,964 ordinary shares represented by 9,069,994 ADSs directly held by Baker Brothers Life Sciences, L.P., and (ii) 4,565,298 ordinary shares represented by 760,883 ADSs directly held by 667, L.P., which may be deemed to be indirectly beneficially owned by the Reporting Persons. The business address of each of the Reporting Persons is c/o Baker Bros. Advisors LP, 860 Washington Street, 3rd Floor, New York NY 10014.
(5)
Beneficial ownership for Mr. Rawcliffe consists of (i) 518,010 ordinary shares represented by 86,335 ADSs and (ii) options to purchase 11,220,307 ordinary shares that are or will be exercisable within 60 days of April 11, 2022.
(6)
Beneficial ownership for Dr. Tayton-Martin consists of (i) 1,800,000 ordinary shares and (ii) options to purchase 7,929,664 ordinary shares that are or will be exercisable within 60 days of April 11, 2022.
(7)
Beneficial ownership for Mr. Bertrand consists of (i) 526,410 ordinary shares represented by 87,735 ADSs and (ii) options to purchase 6,008,328 ordinary shares that are or will be exercisable within 60 days of April 11, 2022.
(8)
Beneficial ownership for Mr. Lunger consists of (i) 313,944 ordinary shares represented by 52,324 ADSs and (ii) options to purchase 2,605,671 ordinary shares that are or will be exercisable within 60 days of April 11, 2022.
(9)
Beneficial ownership for Mr. Wood consists of (i) 57,000 ordinary shares represented by 9,500 ADSs and (ii) options to purchase 2,059,570 ordinary shares that are or will be exercisable within 60 days of April 11, 2022.
(10)
Includes the shares set forth in footnote (2) above and options held by Dr. Behbahani to purchase 1,134,506 ordinary shares that are or will be exercisable within 60 days of April 11, 2022. Dr. Behbahani is a partner of New Enterprise Associates, Inc., which has ultimate voting and investment power over shares held of record by New Enterprise Associates 14, Limited Partnership.
(11)
Beneficial ownership for Mr. Noble consists of (i) 8,145,700 ordinary shares and (ii) options to purchase 11,090,845 ordinary shares that are or will be exercisable within 60 days of April 11, 2022.