Filed Pursuant to Rule 424(b)(5)
Registration No. 333-260945
PROSPECTUS SUPPLEMENT NO. 1
(to Preliminary Prospectus Supplement, dated August 10,
2022)
7,250,000 Shares of Common Stock

Cerevel Therapeutics Holdings, Inc.
This prospectus supplement no. 1 (this
“prospectus supplement”) amends and supplements our preliminary
prospectus supplement, dated August 10, 2022 (the “preliminary
prospectus supplement”), which is in respect of our offering (the
“common stock offering”) of shares of our common stock, par value
$0.0001 per share (the “common stock”), and supplements our
prospectus, dated November 22, 2021 (the “base prospectus” and
as supplemented by the preliminary prospectus supplement, the
“preliminary prospectus”), that forms a part of our Registration
Statement on Form S-3
(Registration Statement No. 333-260945). This prospectus
supplement is being filed to update and supplement the preliminary
prospectus with pricing terms for the common stock offering and
certain other material information with respect to our concurrent
convertible notes offering referred to in the preliminary
prospectus. Accordingly, we have attached such pricing terms and
other material information in a term sheet attached to this
prospectus supplement. Terms used but not defined in this
prospectus supplement have the respective meanings as set forth in
the preliminary prospectus.
This prospectus supplement updates and
supplements the information in the preliminary prospectus and is
not complete without, and may not be delivered or utilized except
in combination with, the preliminary prospectus, including the
documents incorporated by reference therein and any amendments or
supplements thereto. This prospectus supplement should be read in
conjunction with the preliminary prospectus and if there is any
inconsistency between the information in the preliminary prospectus
and this prospectus supplement, you should rely on the information
in this prospectus supplement.
Our common stock is listed on The Nasdaq
Capital Market under the symbol “CERE.” On August 11, 2022,
the last reported sale price of our common stock on The Nasdaq
Capital Market was $35.63 per share.
Investing in our securities involves a high
degree of risk. See “Risk Factors” beginning on
page S-7 of the preliminary
prospectus supplement and elsewhere in the preliminary prospectus
for a discussion of information that should be considered in
connection with an investment in our securities.
Neither the Securities and Exchange Commission
nor any state or foreign securities commission or regulatory
authority has approved or disapproved of these securities or passed
upon the adequacy or accuracy of this prospectus supplement or the
preliminary prospectus. Any representation to the contrary is a
criminal offense.
Joint Book-Running Managers
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MORGAN STANLEY |
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GOLDMAN SACHS & CO. LLC |
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JEFFERIES |
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EVERCORE ISI |
Co-Managers
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LOOP CAPITAL MARKETS |
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SIEBERT WILLIAMS SHANK |
The date of this prospectus supplement is
August 11, 2022.