FORM 3
        
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

Koziel Margaret
2. Date of Event Requiring Statement (MM/DD/YYYY)
12/1/2021 

3. Issuer Name and Ticker or Trading Symbol

Axcella Health Inc. [AXLA]
(Last)        (First)        (Middle)

C/O AXCELLA HEALTH INC., 840 MEMORIAL DRIVE
4. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director                          _____ 10% Owner
___X___ Officer (give title below)        _____ Other (specify below)
Chief Medical Officer /
(Street)

CAMBRIDGE, MA 02139      

(City)              (State)              (Zip)
5. If Amendment, Date Original Filed(MM/DD/YYYY)
 

6. Individual or Joint/Group Filing(Check Applicable Line)

_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 30000 (1)D  

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(MM/DD/YYYY)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date ExercisableExpiration DateTitleAmount or Number of Shares
Stock Option (Right to Buy)  (2)6/27/2029 Common Stock 20800 $9.31 D  
Stock Option (Right to Buy)  (3)1/2/2030 Common Stock 10250 $4.12 D  
Stock Option (Right to Buy)  (4)11/10/2030 Common Stock 11000 $5.04 D  
Stock Option (Right to Buy)  (5)2/9/2031 Common Stock 31050 $6.59 D  
Stock Option (Right to Buy)  (6)6/25/2031 Common Stock 10000 $4.11 D  

Explanation of Responses:
(1) Represents a grant of 30,000 Restricted Stock Units ("RSUs"), each representing a contingent right to receive one share of AXLA common stock. 25% of the shares underlying this grant vested on August 31, 2021, with the remainder vesting in twelve equal quarterly installments thereafter, subject to the Reporting Person's continued service on each such vesting date.
(2) 25% of the shares underlying this option vested and became exercisable on June 27, 2020, with the remainder vesting in twelve equal quarterly installments thereafter, subject to subject to Reporting Person's continued service on each such vesting date.
(3) 25% of the shares underlying this option vested and became exercisable on January 2, 2021, with the remainder vesting in twelve equal quarterly installments thereafter, subject to subject to Reporting Person's continued service on each such vesting date.
(4) 25% of the shares underlying this option vested and became exercisable on November 10, 2021, with the remainder vesting in twelve equal quarterly installments thereafter, subject to subject to Reporting Person's continued service on each such vesting date.
(5) 25% of the shares underlying this option shall vest and become exercisable on February 9, 2022, with the remainder vesting in twelve equal quarterly installments thereafter, subject to subject to Reporting Person's continued service on each such vesting date.
(6) 25% of the shares underlying this option shall vest and become exercisable on June 25, 2022, with the remainder vesting in twelve equal quarterly installments thereafter, subject to subject to Reporting Person's continued service on each such vesting date

Remarks:
Exhibit 24 - Power of Attorney

Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
Koziel Margaret
C/O AXCELLA HEALTH INC.
840 MEMORIAL DRIVE
CAMBRIDGE, MA 02139


Chief Medical Officer

Signatures
/s/ Paul Fehlner, Attorney-in-Fact12/13/2021
**Signature of Reporting PersonDate

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