AYLA

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d)

of the Securities Exchange Act of 1934

June 13, 2022

Date of Report (Date of earliest event reported)

AYALA PHARMACEUTICALS, INC.

(Exact Name of Registrant as Specified in its Charter)

Oppenheimer 4

Rehovot, Israel 7670104

(Address of Principal Executive Offices) (Zip Code)

(857) 444-0553

(Registrant’s telephone number, including area code)

N/A

(Former Name or Former Address, if Changed Since Last Report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):

Securities registered pursuant to Section 12(b) of the Act:

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company  ☒

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.  ☐

On June 13, 2022, Ayala Pharmaceuticals, Inc. (the “Company”) held its Annual Meeting of Stockholders (the “Meeting”). A total of 10,659,177 shares of the Company’s common stock, $0.01 par value per share (the “Common Stock”) were present in person or represented by proxy at the Meeting, representing approximately 75.67% percent of the Company’s outstanding Common Stock as of the April 18, 2022 record date. The following are the voting results for the proposals considered and voted upon at the Meeting, each of which were described in the Company’s Definitive Proxy Statement filed with the Securities and Exchange Commission on April 27, 2022.

Item 1 — Election of one Class II director for a term of office expiring on the date of the annual meeting of stockholders to be held in 2025 and until her respective successor has been duly elected and qualified or until such director’s earlier death, resignation or removal.

Item 2 — Ratification of the appointment of Kost Forer Gabbay & Kasierer, a member of Ernst & Young Global as the Company’s independent registered public accounting firm for the year ending December 31, 2022.

Based on the foregoing votes, Roni Mamluk, Ph.D. was elected and Item 2 was approved.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.