FORM 3
        
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

Mammen Mathai
2. Date of Event Requiring Statement (MM/DD/YYYY)
1/3/2022 

3. Issuer Name and Ticker or Trading Symbol

JOHNSON & JOHNSON [JNJ]
(Last)        (First)        (Middle)

ONE JOHNSON & JOHNSON PLAZA
4. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director                          _____ 10% Owner
___X___ Officer (give title below)        _____ Other (specify below)
EVP, Pharm, R&D /
(Street)

NEW BRUNSWICK, NJ 08933      

(City)              (State)              (Zip)
5. If Amendment, Date Original Filed(MM/DD/YYYY)
 

6. Individual or Joint/Group Filing(Check Applicable Line)

_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 32477.0000 D  

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(MM/DD/YYYY)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date ExercisableExpiration DateTitleAmount or Number of Shares
Employee Stock Options (Right to Buy) (1)2/12/2021 2/11/2028 Common Stock 28927.0000 $129.5100 D  
Employee Stock Options (Right to Buy) (1)2/11/2022 2/11/2029 Common Stock 36098.0000 $131.9400 D  
Employee Stock Options (Right to Buy) (1)2/10/2023 2/10/2030 Common Stock 58130.0000 $151.4100 D  
Employee Stock Options (Right to Buy) (1)2/28/2024 2/28/2031 Common Stock 43149.0000 $164.6200 D  
Restricted Share Units (2)2/3/2023  (2)Common Stock 35951.0000  (2)D  
Restricted Share Units (2)2/8/2024  (2)Common Stock 3929.0000  (2)D  
Restricted Share Units (2)2/10/2023  (2)Common Stock 4545.0000  (2)D  
Restricted Share Units (2)2/11/2022  (2)Common Stock 7418.0000  (2)D  

Explanation of Responses:
(1) Vested and exercisable on the third anniversary of the date of the grant.
(2) Each Restricted Share Unit represents a contingent right to receive one share of Company Common Stock and vests on the third anniversary of the date of grant.

Remarks:
mammenpoa1.txt

Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
Mammen Mathai
ONE JOHNSON & JOHNSON PLAZA
NEW BRUNSWICK, NJ 08933


EVP, Pharm, R&D

Signatures
Raavi Deol, as attorney-in-fact for Mathai Mammen1/13/2022
**Signature of Reporting PersonDate

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