TIDMORPH

RNS Number : 2068F

Open Orphan PLC

14 July 2021

Open Orphan PLC

("Open Orphan" or the "Company")

Directors' Dealings

The Company announces that it has received notification that, on 14 July 2021, Cathal Friel, Executive Chairman of the Company, purchased 1,132,075 ordinary shares of 0.1 pence each in the capital of the Company ("Shares") at a price of 26.5 pence per Share and that Prof. Brendan Buckley, Non-Executive Director of the Company, purchased 188,679 Shares at a price of 26.5 pence per Share.

Following this purchase Cathal Friel is interested in 47,087,086 Shares, representing approximately 7.0 per cent. of the Company's issued ordinary share capital, and Brendan Buckley is interested in 8,034,539 Shares, representing approximately 1.2 per cent. of the Company's issued ordinary share capital.

Cathal Friel, Executive Chairman, Open Orphan, said: "I am delighted to have now had the opportunity to increase my personal stake in Open Orphan plc by today purchasing additional shares, and am equally pleased that Brendan is joining me in doing likewise. These share purchases further demonstrates my and the Board's commitment to the Company, and reiterates my confidence in Open Orphan's future prospects as we enter a period where the infectious disease market is rapidly expanding and expected to grow to in excess of $250bn per annum by 2025.

"We continue to roll out new contract wins and having signed and announced this week and last week, two significant challenge study contract wins for our London office and earlier today a EUR900k contract win for our Breda, Netherlands office. In the past week I was also delighted to confirm that we were solidly EBITDA profitable in H1 2021 and remain on target for a profitable and successful 2021.

"Likewise, earlier today Poolbeg Pharma plc filed its Schedule One confirming that it had successfully raised GBP25m in fresh funds on a pre-money valuation of GBP25m, thus when it completes its IPO in the coming week it should be listing with a market cap of c. GBP50m. This is an excellent start to our strategy of spinning off and montizing our non-core assets. We plan and expect to spin off the other three non-core assets between now and year end; namely our 49% stake in Imutex, our 62.6% stake in PrEP Biopharm and Disease in Motion platform business. Thus, we have a very exciting year ahead for Open Orphan."

For further information please contact:

 
  Open Orphan plc                                                         +353 (0) 1 644 0007 
 Cathal Friel, Executive Chairman 
 
 Arden Partners plc (Nominated Adviser 
  and Joint Broker)                                                      +44 (0) 20 7614 5900 
 John Llewellyn-Lloyd / Richard Johnson 
  / Oscair McGrath 
 
 finnCap Ltd (Joint Broker)                                              +44 (0) 20 7220 0500 
 Geoff Nash / James Thompson / Richard 
  Chambers 
 
 Davy (Euronext Growth Adviser and Joint 
  Broker)                                                                 +353 (0) 1 679 6363 
 Anthony Farrell 
 
 Walbrook PR (Financial PR &                 +44 (0)20 7933 8780 or openorphan@walbrookpr.com 
  IR) 
                                                                        +44 (0)7980 541 893 / 
 Paul McManus / Louis Ashe-Jepson /                                     07747 515 393 / 07502 
  Sam Allen                                                                           558 258 
 
 

Notes to Editors

Open Orphan plc (London and Euronext: ORPH) is a rapidly growing pharmaceutical service/contract research company that is a world leader in testing vaccines and antivirals using human challenge clinical trials. The Company provides services to Big Pharma, biotech and government/public health organisations.

Open Orphan runs challenge studies in London from both its 19-bedroom Whitechapel quarantine clinic, opened in February 2021, and its 24-bedroom QMB clinic which also has a highly specialised virology and immunology laboratory on-site. Open Orphan has a leading portfolio of eight human challenge study models for conditions such as RSV, flu, asthma and COPD. In addition, Open Orphan is also developing the world's first COVID-19 human challenge study model as part of the Human Challenge Programme and has signed a reservation contract with the UK Government for the first three COVID-19 vaccine challenge studies.

Building upon its many years of challenge studies and virology research, the Company is developing an in-depth database of infectious disease progression data. Based on the Company's Disease in Motion(R) platform, this unique dataset includes clinical, immunological, virological and digital (wearable) biomarkers. The Disease in Motion platform has many potential applications across a wide variety of end users including big technology, wearables, pharma and biotech companies. Following COVID-19 there is now a renewed interest and investment in infectious diseases.

Open Orphan's Paris office has been providing biometry, data management and statistics to its many European pharmaceutical clients for over 20 years. For over 15 years, the Company's Netherlands office has been providing drug development consultancy and services, including CMC (chemistry, manufacturing and controls), PK and medical writing, to a broad range of European clients. Both offices are now also fully integrated with the London office and working on challenge study contracts as well as supporting third party trial contracts .

Notification of transactions by Directors, Persons Discharging Managerial Responsibilities ("PDMRs") and persons closely associated with them.

 
 1.   Details of the person discharging managerial responsibilities 
       / person closely associated 
 a)   Name                             C athal Friel 
     -------------------------------  ---------------------------------- 
 2.   Reason for the Notification 
     ------------------------------------------------------------------- 
 a)   Position/status                  E xecutive Chairman 
     -------------------------------  ---------------------------------- 
 b)   Initial notification/amendment   Initial notification 
     -------------------------------  ---------------------------------- 
 3.   Details of the issuer, emission allowance market participant, 
       auction platform, auctioneer or auction monitor 
     ------------------------------------------------------------------- 
 a)   Name                             Open Orphan plc 
     -------------------------------  ---------------------------------- 
 b)   LEI                              213800VT5KBM7JLIV118 
     -------------------------------  ---------------------------------- 
 4.   Details of the transaction(s):section to be repeated for (i) 
       each type of instrument; (ii) each type of transaction; (iii) 
       each date; and (iv)each place where transactions have been 
       conducted 
     ------------------------------------------------------------------- 
 a)   Description of the Financial     Ordinary shares of 0.1 pence each 
       instrument, type of 
       instrument 
     -------------------------------  ---------------------------------- 
      Identification code              ESVUFR 
                                        ISIN GB00B9275X97 
     -------------------------------  ---------------------------------- 
 b)   Nature of the Transaction        Purchase of ordinary shares 
     -------------------------------  ---------------------------------- 
 c)   Price(s) and volume(s)            Price         Volume 
                                         26.5 pence    1,132,075 
                                                      ---------- 
     -------------------------------  ---------------------------------- 
 d)        Aggregated information      As above 
             *    Aggregated volume 
 
 
             *    Price 
     -------------------------------  ---------------------------------- 
 e)   Date of the transaction          14 July 2021 
     -------------------------------  ---------------------------------- 
 f)   Place of the transaction         London Stock Exchange 
     -------------------------------  ---------------------------------- 
 
 
 Details of the person discharging managerial responsibilities 
  / person closely associated 
 Name                              Professor Brendan Buckley 
--------------------------------  ---------------------------------- 
 Reason for the Notification 
-------------------------------------------------------------------- 
 Position/status                   Non-E xecutive Director 
--------------------------------  ---------------------------------- 
 Initial notification/amendment    Initial notification 
--------------------------------  ---------------------------------- 
 Details of the issuer, emission allowance market participant, 
  auction platform, auctioneer or auction monitor 
-------------------------------------------------------------------- 
 Name                              Open Orphan plc 
--------------------------------  ---------------------------------- 
 LEI                               213800VT5KBM7JLIV118 
--------------------------------  ---------------------------------- 
 Details of the transaction(s):section to be repeated for (i) each 
  type of instrument; (ii) each type of transaction; (iii) each 
  date; and (iv)each place where transactions have been conducted 
-------------------------------------------------------------------- 
 Description of the Financial      Ordinary shares of 0.1 pence each 
  instrument, type of 
  instrument 
--------------------------------  ---------------------------------- 
 Identification code               ESVUFR 
                                    ISIN GB00B9275X97 
--------------------------------  ---------------------------------- 
 Nature of the Transaction         Purchase of ordinary shares 
--------------------------------  ---------------------------------- 
 Price(s) and volume(s)             Price         Volume 
                                     26.5 pence    188,679 
                                                  -------- 
--------------------------------  ---------------------------------- 
      Aggregated information       As above 
        *    Aggregated volume 
 
 
        *    Price 
--------------------------------  ---------------------------------- 
 Date of the transaction           14 July 2021 
--------------------------------  ---------------------------------- 
 Place of the transaction          London Stock Exchange 
--------------------------------  ---------------------------------- 
 

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July 14, 2021 04:06 ET (08:06 GMT)

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