RNS Number:2409S
Skyepharma PLC
19 November 2003


For Immediate Release                                    19 November 2003



                         SkyePharma PLC ("the Company")

                    Notification of Major Interest in Shares



In accordance with the Companies Act 1985 (as amended) the Company was informed
by Fidelity Investments on 18 November 2003 that FMR Corp and its direct and
indirect subsidiaries and Fidelity International Limited and its direct and
indirect subsidiaries, both being non-beneficial holders, had increased their
total holding to 43,586,257 ordinary shares of 10p each, representing 7.06% of
the issued share capital of the Company.



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