SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

 

 

FORM 6-K

 

 

REPORT OF FOREIGN PRIVATE ISSUER

Pursuant to Rule 13a-16 or 15d-16 of

the Securities Exchange Act of 1934

 

23 October 2007

 

 

PROTHERICS PLC

(Translation of Registrant’s Name Into English)

 

 

The Heath Business & Technical Park
Runcorn, Cheshire, W47 4QF England

(Address of Principal Executive Offices)

 

Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F.

 

Form 20-F       X              Form 40-F               

 

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1):             

 

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 191(b)(7):             

 

Indicate by check mark whether the registrant by furnishing the information contained in this form is also thereby furnishing the information to the Commission pursuant to Rule 12g3-2(b) under the Securities Exchange Act of 1934.

 

Yes                     No          X     

 

If “Yes” is marked, indicate below the file number assigned to the registrant in connection with Rule 12g3-2(b): 82-              .

 

 

The Registrant is furnishing a copy of its announcements as reported to the Company Announcements Office of the London Stock Exchange.

 

 

SIGNATURES

 

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

 

       

 

PROTHERICS PLC

       

Date: 23 October 2007

 

By:

 

/s/ Rolf Soderstrom

       

Rolf Soderstrom

       

Finance Director

 

 

Protherics PLC Notification of Major Interests in Shares London, UK; Brentwood, TN, US: 23 October 2007 - Protherics PLC ("Protherics" or the "Company"), the international biopharmaceutical company focused on critical care and cancer, announces that on 19 October 2007, in accordance with the Transparency Obligations Directive, a notification of interest in the ordinary share capital of the Company was received from AXA Investment Managers UK Limited on behalf of AXA S.A. and its Group Companies ("AXA"). Details of the interest notified are as follows: 1. Reason for the notification (please tick the appropriate box or boxes) An acquisition of voting rights X An acquisition or disposal of financial instruments which may result in the acquisition of shares already issued to which voting rights are attached An event changing the breakdown of voting rights Other (please specify): 2. Full name of person(s) subject to the AXA S.A., 25 Avenue Matignon, 75008 Paris and its notification obligation: group of companies. 3. Full name of shareholder(s) (if different from 2.): 4. Date of the transaction (and date on which 18 October 2007 the threshold is crossed or reached if different): 5. Date on which issuer notified: 19 October 2007 6. Threshold(s) that is/are crossed or reached: 12% 7. Notified details: A: Voting rights attached to shares Class/type of Situation previous to Resulting situation after the triggering transaction shares the Triggering transaction if possible using Number of Number of Number of Number of voting rights % of voting rights the ISIN CODE Shares Voting shares Rights Direct Direct Indirect Direct Indirect 0702920 39,349,221 39,349,221 829,525 829,525 40,853,708 0.24% 12.04% B: Financial Instruments Resulting situation after the triggering transaction Type of financial Expiration date Exercise/ Conversion Number of voting rights % of voting rights instrument Period/ Date that may be acquired if the instrument is exercised/ converted. Total (A+B) Number of voting rights % of voting rights 41,683,233 12.28% 8. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable : Name of Company/Fund Number of Shares % of issued share capital AXA UK Investment Co ICVC 520,429 0.15336 UK Smaller Companies Fund Indirect Sun Life Pensions Management Ltd 25,000 0.00737 Direct AXA Sun Life 53,913 0.01589 FTSE All Share Tracker Life Direct AXA Sun Life 294,874 0.08689 FTSE All Share Tracker Pension Direct AXA Framlington 750,000 0.22101 SEI UK Equity Indirect AXA Framlington 854,587 0.25183 St James Place Exempt (Pens) Fund Indirect AXA Framlington 961,409 0.28331 St James Place Net (Life) Fund Indirect AXA Framlington 213,646 0.06296 St James Place Offshore Fund Indirect AXA Framlington 320,470 0.09444 Daimler Chrysler Indirect AXA Framlington 3,120,333 0.91951 Throgmorton Trust Indirect AXA Framlington 15,013,453 4.42422 UK Selet Ops Indirect AXA Framlington 13,753,131 4.05282 Equity Income Indirect AXA Framlington 2,000,000 0.58937 Managed Balanced Indirect AXA Framlington 1,500,000 0.44203 UK Smaller Companies Indirect AXA Framlington 500,000 0.14734 BAE Systems Pensions Fund CIF Trustees Indirect AXA Framlington 220,000 0.06483 BAE Systems 2000 Pensions Fund Indirect AXA Framlington onshore private clients 970,000 0.28584 Indirect AXA Framlington onshire private clients 56,250 0.01658 Indirect AXA Sun Life plc 271,631 0.08005 With Profit Transition Fund Direct AXA Life Assurance Society plc 184,107 0.05425 With Profit Transition Fund Direct AXA Framlington 100,000 0.02947 ST James Place Internal Equity & Income UT Indirect Total Direct 829,525 0.24445 Total Indirect 40,853,708 12.03892 TOTAL 41,683,233 12.28337 Proxy Voting: 9. Name of the proxy holder: 10. Number of voting rights proxy holder will cease to hold: 11. Date on which proxy holder will cease to hold voting rights: 12. Additional information: | Ends | For further information please contact: Protherics Nick Staples, Director of Corporate Affairs +44 (0) 7919 480510 Julie Vickers, Company Secretary +44 (0)1928 518010 Financial Dynamics - press enquiries London: Ben Atwell, Lara Mott +44 (0) 20 7831 3113 New York: John Capodanno, Jonathan Birt +1 212 850 5600 Or visit www.protherics.com
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