FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

Donaldson Michael Paul
2. Issuer Name and Ticker or Trading Symbol

Summit Therapeutics Inc. [ SMMT ]
5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director                    _____ 10% Owner
__X__ Officer (give title below)    _____ Other (specify below)
Chief Financial Officer
(Last)          (First)          (Middle)

C/O SUMMIT THERAPEUTICS INC.,, ONE BROADWAY, 14TH FLOOR
3. Date of Earliest Transaction (MM/DD/YYYY)

2/19/2021
(Street)

CAMBRIDGE, MA 02142
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
6. Individual or Joint/Group Filing (Check Applicable Line)

_X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security3. Trans. Date3A. Deemed Execution Date, if any4. Trans. Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
6. Date Exercisable and Expiration Date7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Stock Option (right to buy) $3.52 2/19/2021  D     5110 (1)  (2)6/8/2030 Common Stock 5110  (3)594890 D  

Explanation of Responses:
(1) Represents the forfeiture of performance-based stock options granted to the Reporting Person on June 8, 2020 that were eligible to vest based on certain performance conditions. Upon grant, the target vesting amount was reported in Table II of Form 3. On February 19, 2021, the Compensation Committee of the Board of Directors of the Issuer determined that, based on the Issuer's performance over the applicable performance period, 37,129 shares would vest and 5,110 shares would be forfeited.
(2) As of February 19, 2021, a total of 79,368 shares have vested and 515,522 shares remain eligible to vest from this grant.
(3) Not applicable.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
Donaldson Michael Paul
C/O SUMMIT THERAPEUTICS INC.,
ONE BROADWAY, 14TH FLOOR
CAMBRIDGE, MA 02142


Chief Financial Officer

Signatures
/s/ Michael Paul Donaldson, Attorney-in-Fact2/23/2021
**Signature of Reporting PersonDate

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