BW20030602002028  20030602T110531Z UTC


( BW)(AMVESCAP-PLC)(AVZ)(PHYOF) SAR - Phytopharm PLC

    Business Editors
    UK REGULATORY NEWS

    LONDON--(BUSINESS WIRE)--June 2, 2003--

Lodge with Company Announcements Office and the Panel. A copy must
also be sent to the company the shares of which are acquired.

                                                                                          Date of disclosure 2 JUNE 2003

                                     DISCLOSURE UNDER RULE 3 OF THE RULES GOVERNING
                                      SUBSTANTIAL ACQUISITIONS OF SHARES ("SARs")

Date of acquisition 30 MAY 2003

Acquisition in ........ PHYTOPHARM PLC ...... (name of company)

(1)        Class of voting shares               Number of shares/rights              If rights over shares
           (eg ordinary shares)                 over shares acquired                 acquired, as opposed
                                                                                     to the shares
                                                                                     themselves, specify
                                                                                     nature of rights

           ORDINARY 1P                          350,000 shares                               -
                -                               N/A     rights                               -

(2)        Resultant total holding              Resultant total holding              Total percentage
           of voting shares (and %              of rights over shares
           of total voting shares               (and % of total voting
           in issue)                            shares in issue)

           10,113,882 (26.16%)                                   -                   10,113,882 (26.16%)

(3)        Party making disclosure................ AMVESCAP PLC ...................

(4)        (a)    Name of person acquiring shares or rights over shares  DISCRETIONARY
                                                           MANAGED CLIENTS OF AMVESCAP
                  and, if different, beneficial owner ................................

           (b)    Names of any other persons acting by
                  agreement or understanding (see SAR 5).............................


Signed, for and on behalf of the party named in (3) above........R
CLYDE.....

(Also print name of signatory)............ROBERT CLYDE........................

Telephone and extension number............020 7065 3720.......................

Note. Under SAR 5, the holdings of and acquisitions by persons acting by
agreement or understanding must be aggregated and treated as a holding of or
acquisition by one person. Note 3 on SAR 5 requires persons who must
aggregate holdings to disclose certain disposals.


For full details of the SARs disclosure requirements, see Rules 3 and 5 of the
SARs.  If in doubt, contact the Panel on Takeovers and Mergers, Monitoring Section, Tel. No: 020 7638 0129.
Email:monitoring@disclosure.org.uk

   Short Name: Amvescap PLC
   Category Code: SAD
   Sequence Number: 00005333
   Time of Receipt (offset from UTC): 20030602T120006+0100

    --30--sm/uk*

    CONTACT: Amvescap PLC
             

    KEYWORD: UNITED KINGDOM INTERNATIONAL EUROPE
    INDUSTRY KEYWORD: BANKING HUMAN RESOURCES 
    SOURCE: Amvescap PLC

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