Zargis Medical Announces the Results of a Clinical Study in Hypertrophic Cardiomyopathy (HCM)
06 November 2004 - 7:39AM
PR Newswire (US)
Zargis Medical Announces the Results of a Clinical Study in
Hypertrophic Cardiomyopathy (HCM) PRINCETON, N.J., Nov. 5
/PRNewswire-FirstCall/ -- Researchers at Zargis Medical Corp., a
majority-owned subsidiary of Speedus Corp. (NASDAQ:SPDE), announced
today the results of a clinical study that demonstrated that a
computer-assisted heart sounds analysis algorithm could identify
those patients flagged by a cardiologist as having apical systolic
murmurs that were louder on standing than reclining, a cardinal
sign of obstructive HCM. HCM is implicated in one third of the
cases of sudden cardiac death in young athletes. The full report of
this study will appear in the forthcoming volume of the Texas Heart
Institute Journal. The study involved twelve volunteer subjects who
had been previously diagnosed with HCM, of which four reported
obstructive HCM. Twenty-second recordings were obtained at each of
four standard auscultatory locations in two postures: standing and
reclining. Detailed auscultatory findings were derived by listening
to the heart sound recordings by a cardiologist who was blinded to
the study design. The recordings were analyzed by a computer
algorithm that detects and identifies heart sounds and murmurs, and
provides quantitative measures of the heart sounds. The algorithm
results were compared with the auscultatory findings provided by
the cardiologist. A high degree of concordance between the
cardiologists' auscultatory findings and computer analyses was
obtained. The systolic energy was found to correlate well with
judgments of the relative loudness of murmurs in different
postures. Those three subjects which were flagged by the
cardiologist as having apical systolic murmurs that were louder on
standing, were identified by the algorithm as having apical
systolic murmurs with higher systolic energies in the standing
posture. These results demonstrate that there are detectable
acoustic features of heart sound recordings that are associated
with auscultatory findings of obstructive HCM. According to
Managing Director John Kallassy, "There is a clear and immediate
need for a cost effective screening method that could help to
identify young athletes at risk of sudden cardiac death due to HCM.
This result holds promise of developing a cost-effective and
readily available test for screening young athletes." About Zargis
Medical Corp. Zargis Medical Corp. was formed in January 2001 when
Siemens Corporate Research Inc., a subsidiary of Siemens AG
(NYSE:SI), and Speedus Corp. (NASDAQ:SPDE) co-invested in Zargis to
further develop and commercially market an advanced acoustic
technology for detecting abnormalities identified through analysis
of heart sounds. Based in Princeton, New Jersey, Zargis is
developing advanced diagnostic decision support products and
services for primary care physicians, cardiologists and other
healthcare professionals. For additional information on Speedus
Corp. or Zargis Medical, contact John Kallassy, 718.567.4358, , or
visit their websites at http://www.speedus.com/ and
http://www.zargis.com/. For additional information on Siemens
Corporate Research, visit their website at
http://www.scr.siemens.com/. Statements contained herein that are
not historical facts, including but not limited to statements about
the Company's product, corporate identity and focus, may be
forward-looking statements that are subject to a variety of risks
and uncertainties. There are a number of important factors that
could cause actual results to differ materially from those
expressed in any forward- looking statements made by the Company,
including, but not limited to, the continuing development of the
Company's sales, marketing and support efforts. DATASOURCE: Zargis
Medical Corp. CONTACT: John Kallassy of Speedus Corp.,
+1-718-567-4358, or Web site: http://www.zargis.com/
http://www.speedus.com/ http://www.scr.siemens.com/
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