PAI Paion

         Person/company obliged to make the notification: 
 Name:      Avlar BioVentures Limited
 Place:     Madingley, Cambridge
 State:     England, United Kingdom
  
 Name:      Avlar BioVentures Fund II Limited Partnership
 Place:     Madingley, Cambridge
 State:     England, United Kingdom
  
 Name:      Advanced Technology Management Limited
 Place:     Huntingdon, Cambridgeshire
 State:     England, United Kingdom
  
 Name:      Avlar BioVentures Scottish GP Limited
 Place:     Edinburgh
 State:     Scotland, United Kingdom
  
 Name:      Avlar BioVentures Scottish Limited Partnership
 Place:     Edinburgh
 State:     Scotland, United Kingdom
     Information on Issuer: 
 Name:        PAION AG
 Address:     Martinstr. 10-12, 52062 Aachen
 Place:       Aachen
 State:       Germany
     Voting rights notification: 
    Pursuant to Sec. 21 para. 1 WpHG we have been notified on 30 October 2008
* by Avlar BioVentures Limited that their proportional share in the voting rights of our company on 30 June 2008 passed
the threshold of 3 % and as of such day amounts to 3.57 % (878,311 voting rights). Thereof, 3.49 % (857,873 voting
rights) are attributed to them pursuant to Sec. 22 para. 1 sentence 1 no. 2 and sentence 2 WpHG and Sec. 22 para. 1
sentence 1 no. 6 WpHG and 0.08 % (20,438 voting rights) are attributed to them pursuant to Sec. 22 para. 1 sentence 1
no. 2 WpHG.* by Avlar BioVentures Fund II Limited Partnership that their proportional share in the voting rights of our
company on 30 June 2008 passed the threshold of 3 % and as of such day amounts to 3.49 % (857,873 voting rights).
Thereof, 3.49 % (857,873 voting rights) are attributed to them pursuant to Sec. 22 para. 1 sentence 1 no. 2 WpHG.* by
Advanced Technology Management Limited that their proportional share in the voting rights of our company on 30 June 2008
passed the threshold of 3 % and as of such day amounts to 3.71 % (912,309 voting rights). Thereof, 3.49 % (857,873
voting rights) are attributed to them pursuant to Sec. 22 para. 1 sentence 1 no. 2 and sentence 2 WpHG and 0.22 %
(54,436 voting rights) are attributed to them pursuant to Sec. 22 para. 1 sentence 1 no. 2 WpHG.* by Avlar BioVentures
Scottish GP Limited that their proportional share in the voting rights of our company on 30 June 2008 passed the
threshold of 3 % and as of such day amounts to 3.49 % (857,873 voting rights). Thereof, 3.49 % (857,873 voting rights)
are attributed to them pursuant to Sec. 22 para. 1 sentence 1 no. 2 and sentence 2 WpHG.* by Avlar BioVentures Scottish
Limited Partnership that their proportional share in the voting rights of our company on 30 June 2008 passed the
threshold of 3 % and as of such day amounts to 3.49 % (857,873 voting rights). Thereof, 3.49 % (857,873 voting rights)
are attributed to them pursuant to Sec. 22 para. 1 sentence 1 no. 2 and sentence 2 WpHG.    Aachen, 3 November 2008
    PAION AG
    The Management Board
     Contacts: 
    Dr. Peer Nils Schr�der
Director of Corporate Communications & Investor Relations
Phone: +49 241 4453-152
E-mail: pn.schroeder@paion.com
 www.paion.com
or
Teathers Limited
Nomad and broker (AIM)
Shaun Dobson/Claes Sp�ng
Phone +44 20 7426 9000

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