SHANGHAI, July 22,
2024 /CNW/ -- The molecular design strategy and
experimental results of Bright Gene's dual GLP-1/GIP receptor
agonist, BGM0504, have been published online in Scientific Reports,
a sub-journal of Nature, on July 19,
2024. Bright Gene (Stock Code: 688166.SH) is an innovative
pharmaceutical company emerging on the international stage, is
focused on developing best-in-class pharmaceuticals to improve
patient health globally.
The article, titled "Molecular Dynamics Guided Optimization of
BGM0504 Enhances Dual Target Agonism for Combating Diabetes and
Obesity", presents the findings of BGM0504's
development.
BGM0504, an AI-assisted designed dual GIP and GLP-1 receptor
agonist, demonstrates superior efficacy in both in vitro and
in vivo experiments. Using AI-driven computer simulations,
Bright Gene has discovered that optimal interaction between the
glutamate residues on both GLP-1R and GIPR and the K20 residue of a
peptide agonist provide superior activity. This interaction is a
key insight not evident in cryo-EM studies. BGM0504 was designed to
preserve the free amino group of the K20 residue by shifting the
acylation point to position 40 of BGM0504. This design resulted in
a 3-fold increase in agonistic effects on GLP-1R and GIPR, with
superior therapeutic outcomes in
diabetic and obesity mouse models.
About Bright Gene and BGM0504
Bright Gene (Stock Code: 688166.SH) is an innovative
pharmaceutical company focused on developing best-in-class
pharmaceuticals. The company integrates APIs and formulations,
combining generic and innovative drugs to meet global clinical
needs. BGM0504 is a dual GIP/GLP-1 receptor agonist for treating
type 2 diabetes, obesity, and NASH, currently in the late stages of
Phase II clinical trials.
Reference
Yuan, J., Liu, W., Jiang, X. et al. Molecular dynamics-guided
optimization of BGM0504 enhances dual-target agonism for combating
diabetes and obesity. Sci Rep 14, 16680 (2024).
https://doi.org/10.1038/s41598-024-66998-8
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SOURCE Bright Gene