RNS Number:4358S
Skyepharma PLC
24 November 2003


For Immediate Release                                        24 November 2003



                         SkyePharma PLC ("the Company")

                    Notification of Major Interest in Shares



In accordance with the Companies Act 1985 (as amended) the Company was informed
by Fidelity Investments on 21 November 2003 that FMR Corp and its direct and
indirect subsidiaries and Fidelity International Limited and its direct and
indirect subsidiaries, both being non-beneficial holders ("Fidelity"), had
increased their total holding to 55,676,356 ordinary shares of 10p each,
representing 9.01% of the issued share capital of the Company.  In addition
Fidelity have informed the Company that they also hold 5,000,000 SkyePharma PLC
6% Convertible Bonds due 2005.



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