RNS Number:0065U
Skyepharma PLC
08 January 2004


Immediate Release                             8 January 2004



                         SkyePharma PLC ("the Company")

                    Notification of Major Interest in Shares


In accordance with the Companies Act 1985 (as amended) the Company was informed
by Fidelity Investments on 7 January 2004 that FMR Corp and its direct and
indirect subsidiaries and Fidelity International Limited and its direct and
indirect subsidiaries, both being non-beneficial holders ("Fidelity"), had
increased their total holding to 83,024,051 ordinary shares of 10p each,
representing 13.42% of the issued share capital of the Company. In addition
Fidelity have informed the Company that they also hold 5,030,000 SkyePharma PLC
6% Convertible Bonds due 2005.


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