Bruker Daltonics Showcasing Novel Proteomics Solutions Based on Mass Spectrometry at the 7th HUPO World Congress 2008Bruker's ne
17 August 2008 - 9:00PM
Business Wire
Bruker Daltonics today is showcasing several new high performance
mass spectrometry products and applications for proteomics at the
7th HUPO World Congress 2008: maXis� is the world�s first high
speed Ultra High Resolution TOF (UHR-TOF) mass spectrometer
platform, and truly represents a revolution in tandem mass
spectrometry. maXis offers exceptional proteomics performance with
sub-ppm mass accuracy, mass resolution of 40,000 to 60,000 across a
broad mass range, outstanding sensitivity and five orders of
dynamic range - all at the high spectral rate of 20 Hz for MS and
MS/MS that is essential for quantitative proteomics and to take
full advantage of ultra-high performance liquid chromatography. ETD
II is the next-generation electron transfer dissociation module for
Bruker�s HCTultra� high capacity ion trap. It is based on a novel
and compact nCI (negative chemical ionization) source with
increased ETD/PTR reactant ion generation, resulting in rapid,
confident characterization of PTMs such as phosphorylations or
glycosylations at sub-fmol sensitivity. In combination with the
major and fundamental ETD efficiency and sensitivity advantages of
the spherical high capacity trap design, ETD II is designed to
provide the most sensitive, fastest and most robust ETD
fragmentation. Due to HCTultra�s inherent m/z range of greater
3,000 and its superior mass resolution that can resolve 3+ and 4+
charge states of peptides on-the-fly at full analytical speed,
ETD/PTR on the HCT-Ultra can even be used for up to 12 kDa proteins
and beyond. MALDI-TDS� Top-Down Sequencing (TDS) solution provides
unparalleled levels of information from undigested proteins in
pharmaceutical and biotechnology applications, including C- and N-
terminal assignments even in the case of N-terminally blocked
proteins. MALDI-TDS is available on Bruker�s top-of-the line
ultraflex� III TOF/TOF system for the characterization of
PEGylation sites and other protein modifications of vital
importance in fields such as recombinant protein production,
biologics drug development and quality control. MALDI-TDS has
clearly proven its usefulness in the recent ABRF Protein Research
Group (PRG) 2008 Study for the identification and differentiation
of various truncated proteins of the same origin and provided 100%
protein sequence coverage. Bruker�s unique SmartBeam� is the
enabling technology for MALDI-TDS, complemented by next generation
BioTools 3.2 top-down bioinformatics. The high sensitivity
SmartBeam� MALDI ion funnel source has now been coupled with the
ultra-high mass resolution apex-ultra� FTMS, representing a
�perfect match� for MALDI small molecule tissue imaging, including
drugs and metabolites from animals dosed at therapeutic levels,
e.g. at or below 5 mg/kg. With mass resolution greater than 900,000
(at 7 Tesla), the cluttered spectra produced in small molecule
MALDI imaging of tissue samples are readily resolved, allowing for
the first time MALDI-MS imaging of small molecules without the
requirement to use MS/MS (SRM) for chemical background suppression.
The high mass accuracy combined with Bruker�s SmartFormula�
software automatically provides sum formula determination for
detected molecules. This new imaging solution promises to advance
areas such as drug development and delivery, clinical and pathology
research, as well as other areas such as lipidomics. EASY-nLC� is a
Bruker-supported nanoscale LC system with 1D and 2D separation
capabilities. Due to the true split-free gradient mixing it avoids
cumbersome maintenance, and guarantees robust, steady and reliable
operation. EASY-nLC dramatically reduces total solvent consumption
and enables fast separations with peak widths less than 5 sec. The
control by Bruker�s Hystar� software supports all proteomics
applications on the maxis, micrOTOF-Q II, HCT ion trap, Flex MALDI
and apex FTMS instrument series for complete, turn-key LC/MS/MS
solutions. The new Bruker mass spectrometry products and
applications for proteomics will be presented throughout the HUPO
conference with more than 30 scientific contributions. During two
Bruker Daltonics� luncheon seminars on Monday and Tuesday titled
�(R)evolution in Biomarker Discovery�, a prestigious researcher�s
panel including Helmut Meyer (MPC Bochum), Andrew Pitt (Univ.
Glasgow) and Ron Heeren (FOM Amsterdam) will present talks
detailing proteomics applications based on the novel developments.
Bruker Daltonics Executive Vice President Dr. Michael Schubert
commented: "At this year's HUPO World Congress in Amsterdam, Bruker
Daltonics is continuing its history of market leading innovations
and is proudly releasing the maXis, an instrument with
unprecedented, simultaneous high speed and ultra-high resolution
performance across a broad mass range. In addition, Bruker
Daltonics is greatly expanding the capabilities of its existing
products through the release of several important enhancements, as
well as new and innovative applications." For further information
on the HUPO conference, please see www.hupo2008.org. For more
information about Bruker Daltonics and Bruker Corporation (NASDAQ:
BRKR), please visit www.bdal.com and www.bruker.com. EASY-nLC(TM)
is a trademark of Proxeon Biosystems, Denmark
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