Bruker and Carl Zeiss Announce Collaboration to Advance Molecular Histology
28 May 2009 - 9:00PM
Business Wire
Bruker Daltonik GmbH and Carl Zeiss MicroImaging GmbH today
announced the integration of the MIRAX Virtual Slide Scanner
from Carl Zeiss into Bruker�s MALDI Molecular
Imager�. The goal of the Bruker�Carl Zeiss collaboration
is to advance molecular histology research by providing an
integrated solution (for research use only) for biological tissue
research and pathology that adds non-targeted molecular information
and �molecular contrast� to histology.
The MALDI Molecular Imager is a molecular imaging system
based on matrix-assisted laser desorption ionization (MALDI)
time-of-flight (TOF) mass spectrometry directly from tissue
sections. It allows histology researchers to measure spatially
resolved peptide, protein and lipid profiles in tissue sections.
MALDI imaging is a non-targeted, broadly applicable molecular
imaging approach without the need for any antibody or nucleotide
probe. Tissue-type specific molecular signatures (e.g. from tumors)
can be generated and used for biomarker discovery and molecular
histology.
A major bottleneck in the interpretation of MALDI imaging data
in pathology research has been the interpretation of results in a
histological context. Until now, this has required repeated
switching between evaluated MALDI molecular images and microscope
views. The integration of Carl Zeiss� MIRAX Slide Scanner
results into the MALDI Molecular Imager solution allows the
direct overlay of the full microscopic image with the full
molecular and spectral information in one convenient visualization
software tool, enabling true untargeted molecular histology.
Dr. S�ren-Oliver Deininger, MALDI Imaging Product Specialist at
Bruker Daltonics, explained: �Bruker has been the market and
commercial technology leader in MALDI imaging for several years.
Proprietary technologies such as the smartbeam� laser for
best spectra quality at highest speed and best spatial resolution,
as well as the Bruker ImagePrep� for easy and reproducible
sample preparation, have turned MALDI imaging into a mainstream
research application. Now, the full integration of the MIRAX
virtual slides allows tissue and pathology researchers for the
first time to evaluate their results directly in the histological
context with the full spatial resolution of optical microscopy and
the molecular information from MALDI imaging.
�This integrated molecular histology solution will significantly
accelerate clinical pathology research, particularly in oncology,
where the untargeted molecular information is expected to reveal
additional subtle changes in tissue that cannot be distinguished by
traditional histology methods today.�
�The integration of the MIRAX Virtual Slide Scanner into the
MALDI Molecular Imager solution is a very good example of how the
combination of two innovative technologies can create new benefits
for biomedical research. With two technology leaders working
together, we believe that we have a strong foundation for a novel,
breakthrough histology solution. We look forward to working closely
together with Bruker,� said Dr. Richard Ankerhold, business unit
manager from Carl Zeiss.
Dr. Axel Walch, a pathologist at the Helmholtz Centre in Munich,
and a user of both the MALDI Molecular Imager and the
MIRAX slide scanner, commented: �The protein expression
observed in MALDI Imaging data cannot be fully understood without
the underlying histological information:�the�correlation of�the
MALDI image with a�micrometer-resolution microscopic image
is�therefore mandatory for�MALDI Imaging in clinical research. The
Zeiss Mirax Scanner has the true advantage of online scalable high
lateral resolution that can zoom in�quickly to any tissue sections
investigated by MALDI. Merging both techniques, Bruker MALDI
Imaging and�MIRAX virtual microscopy, leads to synergistic effects
with outstanding benefits for clinical research. It truly completes
the�superior Bruker product line for imaging comprising of sample
preparation, high performance MALDI mass spectrometry and highly
sophisticated software for data interpretation.�
For further product information, please visit
www.bdal.com/molecular-histology.
ABOUT BRUKER DALTONICS: For more information about Bruker
Daltonics and Bruker Corporation (NASDAQ: BRKR), please visit
www.bdal.com or www.bruker.com.
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