Bruker and JMI Laboratories Announce a Collaboration for Mass Spectrometry-based Microbial Identification of Fungi
18 June 2012 - 11:00PM
Business Wire
At the 112th General Meeting of the American Society of
Microbiology (ASM) in San Francisco, Bruker announces a new
collaboration with JMI Laboratories in the field of fungal
identification by proteomics fingerprinting. JMI Laboratories is
applying the Bruker MALDI Biotyper™ to a wide variety of
international antimicrobial resistance surveillance studies
utilizing the SENTRY Program platform (>300 sites in more than
40 countries and six continents). Among these programs,
comprehensive sampling of invasive fungal infections involves
nearly 2,000 samples of yeast and moulds, each requiring the
highest quality of identifications, and currently requiring gene
amplification and sequencing. The Bruker MALDI Biotyper will
streamline reference-quality identifications via its rapidly
evolving library of clinically important fungi.
Invasive fungal infections are associated with high morbidity
and mortality while prompt diagnosis can result in more optimized
therapy reducing both mortality and costs of treatment. Current
methods for identification of fungi include biochemical,
phenotypic, microscopic and molecular methods. Numerous
peer-reviewed studies have examined the capabilities of the
MALDI Biotyper for fungal identification and Bruker recently
launched a separate RUO library of filamentous fungi at ECCMID
2012. MALDI Biotyper testing can be completed in hours and
therefore has the potential to produce more rapid results than
traditional microbiological testing methods.
The goals of this collaboration include the validation and
expansion of the MALDI Biotyper database of protein
fingerprint profiles for identification of unusual filamentous
fungi, and the expansion of protein fingerprint profiles for
identification of unusual yeast species. It therefore will enhance
the MALDI Biotyper database as well as determine if the
Bruker MALDI Biotyper platform can partially or fully
replace the laborious traditional biochemical testing currently
used by JMI Laboratories.
Dr. Mariana Castanheira, research scientist at JMI Laboratories
and speaking for Professors M.A. Pfaller and R.N. Jones stated:
"Contemporary understanding of emerging resistances among
antifungal agents requires companion use of reference
susceptibility test methods such as CLSI and EUCAST and
molecular-level reference-quality organism identifications. The
Bruker MALDI Biotyper provides us with an evolving degree of
species identification certainty and processing value."
George Goedesky, Executive Director of Microbiology Business
Development at Bruker Daltonics commented: “We are very excited to
establish the collaboration with JMI Laboratories in the field of
fungal identification. Compared to classical identification
methods, the MALDI Biotyper has been demonstrated to have a
superior performance for common yeast representing roughly 95% of
the isolates in most clinical microbiology laboratories. With JMI’s
acknowledged expertise in the field and large collection of
sequenced fungal isolates, especially rare and unusual yeast and
moulds, we will even further improve the coverage of the MALDI
Biotyper reference library for this very challenging organism
group.”
About the Bruker MALDI Biotyper
Bruker's dedicated MALDI Biotyper solution enables
molecular identification, taxonomical classification or
dereplication of microorganisms like bacteria, yeasts and fungi.
Classification and identification of microorganisms is achieved
reliably and fast using proteomic fingerprinting with
high-throughput MALDI-TOF mass spectrometry. Applications include
clinical routine microbial identification, environmental and
pharmaceutical analysis, taxonomical research, food and consumer
product processing and quality control, as well as in marine
microbiology. Bruker's robust MALDI Biotyper method requires
minimal sample preparation efforts and offers low cost per sample.
The MALDI Biotyper is available in a research-use-only
version, as well as in an IVD version according to the EU directive
EC/98/79 in various EU countries. For more information, please
visit www.bruker.com/MALDIBiotyper
About Bruker Corporation
Bruker Corporation (NASDAQ: BRKR) is a leading provider of high
performance scientific instruments and solutions for molecular and
materials research, as well as industrial and applied analysis. For
more information: www.bruker.com.
For more information on JMI labs, please visit
www.jmilabs.com
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