BRKR Bruker Corporation

Major Bruker Innovations at ASMS 2013 include:

• Game-changing >10 million eXtreme Resolution on new solariX™ XR System
• Industry-leading 50 Gbit/sec sampling for 105 dynamic range on >40,000 Full-Sensitivity Resolution, 50 Hz MS/MS impact™ HD System
• Novel CaptiveSpray NanoBooster™ enables over 8,400 unique protein IDs in proteomics on impact™ HD UHR-QTOF System
• New EVOQ™ Elite ER LC-triple quad mass spectrometer for undistorted peptide quantification with proprietary VIP™ (vacuum-insulated probe) HESI source

40,000 Full-Sensitivity Resolution (FSR). It opens up enhanced analytical performance levels for all applications where trace analysis from complex, high-background matrices is a challenge – such as biomarker research, identification of impurities or residue screening.

Thanks to its extreme sensitivity, broad mass-transfer ion optics and the fastest 50 Gbit/sec sampling technology, a dynamic range of 5 orders of magnitude is achieved at UHPLC speeds, with up to 50 Hz MS/MS capabilities. This is a prerequisite for high-resolution, accurate mass detection of low abundance compounds in nano- and UHPLC peaks.

Moreover, the Impact HD comes equipped with unique Instant Expertise™ software: intelligent self-optimizing MS/MS acquisition establishes optimal experimental conditions that are independent of sample amount or complexity. This translates into higher productivity and expert-caliber results - the first time!

In combination with the impact HD, Bruker also introduces the novel CaptiveSpray nanoBooster™ for new performance levels in proteomics and glycoanalysis. This newest version of Bruker’s highly regarded CaptiveSpray ion source with proprietary dopant-enriched ionization boosts nano-flow sensitivity, and drives up protein and peptide ID rates significantly. The emphasis of higher charge states and its sensitivity gain also provide highest ETD sensitivity with Bruker’s amaZon ETD ion trap mass spectrometer, and allow for the analysis of low-level glycopeptides that were previously not measurable.

“Highest dynamic range really is compelling for proteomics analysis when it can genuinely be delivered at UHPLC speeds,” commented Dr. Carsten Bässmann, Bruker’s Head of ESI Applications Development. “At ASMS 2013, we can for this first time show the unique identification of more than 8,440 proteins at a low false discovery rate (FDR) below 1%, in a proteomics sample, using an integrated workflow combining 2D-LC separations with a CaptiveSpray nanoBooster™ source on our new impact HD system.”

EVOQ™ Elite ER:

The new EVOQ Elite ER highlights the premiere of LC/MS/MS triple-quadrupole (TQ) technology from Bruker at ASMS. The new EVOQ Elite ER is the latest addition to the EVOQ family of LC-TQ systems, with an extended mass range to 2,000 m/z, for peptide quantitation or other high m/z applications.

The EVOQ LC-TQ platform features major innovations:

• the industry’s first Vacuum-Insulated Probe (VIP™) heated electrospray ionization (HESI) source preserves and ionizes thermally fragile molecules without discrimination and with outstanding sensitivity
• the Active Exhaust atmospheric pressure ionization source with a robust orifice vacuum interface significantly enhances quantitative robustness for difficult samples
• flat-tuning, proprietary Interlaced Quadrupole Dual Funnel (IQ-DF™) maximizes sensitivity
• Bruker’s patented lens-free triple-quad mass filter design enhances MRM ease and performance
• novel PACERTM software enables exception-based data-review, a revolutionary feature that significantly reduces the error rate for quantitative analysis;

All EVOQ LC-TQ systems incorporate Bruker’s new Advance™ Ultra-High Pressure Liquid Chromatography (UHPLC) systems. The Advance HPLC, UHPLC, and the UHPLC-OLE (on-line extraction) products offer ultra-low dead volume, which enables excellent reproducibility at analytical flow-rates, an integrated column-oven, and bench-space savings. Paired with the industry-leading CTC auto-sampler, the EVOQ LC-TQ delivers the precision and accuracy required for sustained, high-sensitivity LC-MRM quantitative analysis.

Rohan Thakur, Ph.D., Vice President and General Manager of Bruker’s Quadrupole MS Business, stated: “The debut of the EVOQ LC-TQ at ASMS marks the first time that Bruker has brought LC triple quad technology to the premiere meeting for mass spectrometry. The key innovations in the EVOQ systems are designed to erase the pain points in today’s high volume applied markets laboratories. Laboratories supporting food testing (pesticide residues or adulterants), environmental labs (industrial pollutants or personal care products), or toxicology (drug testing/doping, pain management) will benefit from the superior performance of the EVOQ family. Bruker’s commitment to driving Innovation with Integrity is not just a tagline, it is our core philosophy.”

Please join Bruker at its ASMS booth #110, and at Bruker’s ASMS press conference on Monday, June 10th, 2013 at 9:30 am to 10:30 am CDT at the Minneapolis Hilton Hotel, Conrad Room D (breakfast served, by registration only).

ABOUT BRUKER CORPORATION (NASDAQ: BRKR)

Bruker is a leading provider of high-performance scientific instruments and solutions for molecular and materials research, as well as for industrial, diagnostics and applied analysis. For more information: www.bruker.com

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Bruker DaltonicsVicky Lander, +1-978-663-3660Director of Global Marketing Communicationsvicky.lander@bdal.com