MINNEAPOLIS, March 12, 2018 /PRNewswire/ -- At the 2018 US
HUPO Conference, Bruker (NASDAQ: BRKR) and Evosep announce that
they have executed a co-development and co-marketing agreement for
the Evosep One chromatography system to work seamlessly with
Bruker's timsTOF Pro ultra-high resolution quadrupole time
of flight mass spectrometer. The timsTOF Pro is
powered by TIMS (Trapped Ion Mobility Separation) and the
PASEF (Parallel Accumulation Serial Fragmentation) method to
provide an additional dimension of fast ion mobility separation
with near 100% duty cycle for faster and more sensitive complex
mixture analysis. This unique combination of speed,
robustness and ultra-high sensitivity is intended to deliver
critical performance required for large cohort clinical proteomics
studies, ushering in the era of nanoflow LC-MS/MS in clinical
research.
![Evosep One and timsTOF Pro, a revolutionary combination of robustness, speed and throughput in proteomics Evosep One and timsTOF Pro, a revolutionary combination of robustness, speed and throughput in proteomics](https://mma.prnewswire.com/media/652696/EvosepOne_timsTOFPro.jpg)
Bruker's revolutionary timsTOF Pro for high
sensitivity proteomics can now be integrated with the Evosep
One (www.Evosep.com) separation device for
high-throughput clinical proteomics. The Evosep
One is a novel chromatography system for large cohort
proteomics, optimized for >200 samples/day and > 90% MS
utilization. Its LC peak widths of ~2 seconds for ~5 minute
gradients have been combined with the PASEF method on the
timsTOF Pro with MS/MS rates >150 Hz. The novel
combination already delivers superb sensitivity (50ng HeLa) and
high throughput for LFQ of ~1,200 proteins in ~5 minutes. For
large sample cohorts, this enables biomarker research and
validation on >200 samples per day - a breakthrough for clinical
proteomics research. Under the co-development part of the
agreement, Bruker and Evosep will work together to further
integrate the two systems by enabling control of both the
Evosep One and the timsTOF Pro using
Bruker's Hystar LC-MS control software, and working to enhance the
already impressive performance of the combination.
Nicolai Bache, Head of
Applications at Evosep, commented: "We are excited about the
collaboration and integration as the outstanding scan speed and
sensitivity of the timsTOF Pro powered by PASEF is
the perfect match for the short robust gradients with virtually no
overhead that the Evosep One delivers."
Gary Kruppa, Vice President for
Proteomics at Bruker Daltonics, elaborated: "The Evosep One
is a perfect front-end solution for the timsTOF Pro when
high-throughput is required, as it leverages the advantages of
PASEF, putting world class biomarker discovery and
validation capabilities in the hands of clinical
researchers."
About Bruker Corporation (NASDAQ: BRKR)
For more than 55 years, Bruker has enabled scientists to make
breakthrough discoveries and develop new applications that improve
the quality of human life. Bruker's high-performance scientific
instruments and high-value analytical and diagnostic solutions
enable scientists to explore life and materials at molecular,
cellular and microscopic levels. In close cooperation with our
customers, Bruker is enabling innovation, improved productivity and
customer success in life science molecular research, in applied and
pharma applications, in microscopy and nanoanalysis, and in
industrial applications, as well as in cell biology, preclinical
imaging, phenomics and proteomics research, microbiology and
molecular pathology research. For more information, please visit:
www.bruker.com.
Media
Contact:
|
Investor
Contact:
|
Gary Kruppa,
Ph.D.
|
Miroslava
Minkova
|
Bruker Daltonics VP
of Proteomics
|
Head of Investor
Relations
|
T: +1 (978) 663-3660,
ext. 1489
|
T: +1 (978) 663-3660,
ext. 1479
|
E:
gary.kruppa@bruker.com
|
E:
miroslava.minkova@bruker.com
|
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SOURCE Bruker Corporation