Bruker Introduces Enhanced 3D Holographic Stimulation for Optogenetics on its Ultima 2Pplus Multiphoton Microscope
14 June 2022 - 9:00PM
Business Wire
New NeuraLight 3D Ultra Module Expands
Neuroscience Research Capabilities
Bruker Corporation (Nasdaq: BRKR) today announced the release of
the NeuraLight 3D Ultra™ module to support advanced
neuroscience and optogenetics research applications on Bruker’s
Ultima multiphoton microscopes. NeuraLight 3D Ultra provides
revolutionary 3D holographic photostimulation, specifically
optimized for functional and large-scale studies of neural networks
and brain computation. Building upon Bruker’s proprietary spatial
light modulator (SLM) technology, the NeuraLight 3D Ultra
module utilizes a new, larger liquid crystal chip that unlocks
access to a larger field of view, improved targeting precision, and
a market-leading speed of 600 hologram frames per second. Paired
with the imaging capabilities of the Ultima 2Pplus microscope, it
uniquely allows researchers to study mechanisms of behavior,
perception, and disease at a larger scale and on a time scale that
is reflective of the underlying biology.
“The system is performing very well in our laboratory, and we’re
excited about the NeuraLight 3D Ultra’s speed, field of
view, and resolution, which will enable us to perform all-optical
interrogation experiments with greater fidelity and precision,”
said Dr. Adam Packer, Wellcome Trust Sir Henry Dale Fellow at the
University of Oxford. “The new format SLM and associated optical
relays offer a better tradeoff between field of view and resolution
that will be advantageous to addressing larger numbers of cells
with improved accuracy. Additionally, the very fast update speed of
the system will make it possible to activate sequences of cells at
a high rate.”
“We are pleased to continue to develop innovative
instrumentation in close collaboration with leaders in neuroscience
research,” added Xiaomei Li, Ph.D., Vice President and General
Manager for Bruker’s Fluorescence Microscopy Business. “With its
largest in-class field of view in fast resonant mode, the Ultima
2Pplus microscope equipped with NeuraLight 3D Ultra is an
optimized solution for all-optical interrogations of the
brain.”
About NeuraLight 3D Ultra
The NeuraLight 3D Ultra is a module that strengthens and
diversifies the functionality of Bruker’s Ultima multiphoton
microscopes. These pioneering imaging systems have a proven track
record of facilitating complex research in neuroscience and were
first to enable simultaneous imaging and photostimulation of
biological samples. NeuraLight 3D Ultra easily couples to
one of the optical ports of the Ultima microscope to allow for
independent imaging and simultaneous multicellular
photostimulation. Comprehensive software enables user-friendly
selection of targets in three dimensions with well-defined timing.
The NeuraLight 3D Ultra module is available as an option for
all new Ultima 2Pplus multiphoton microscopes and as an upgrade for
selected models of microscopes produced since 2006. Ultima
multiphoton systems equipped with NeuraLight 3D Ultra and
paired with Bruker’s electrotunable lens option provide complete
solutions for all-optical reading and writing of neuronal
activity.
About Bruker Corporation (Nasdaq: BRKR)
Bruker is enabling scientists to make breakthrough discoveries
and develop new applications that improve the quality of human
life. Bruker’s high-performance scientific instruments and
high-value analytical and diagnostic solutions enable scientists to
explore life and materials at molecular, cellular, and microscopic
levels. In close cooperation with our customers, Bruker is enabling
innovation, improved productivity, and customer success in life
science molecular research, in applied and pharma applications, in
microscopy and nanoanalysis, and in industrial applications, as
well as in cell biology, preclinical imaging, clinical phenomics
and proteomics research and clinical microbiology. For more
information, please visit: www.bruker.com.
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