Aastrom Biosciences Announces Second Clinical Trial for Bone Fractures in Spain
13 December 2005 - 9:45PM
PR Newswire (US)
-- New Trial Expected to Further Company's Knowledge of Bone
Regeneration -- ANN ARBOR, Mich., Dec. 13 /PRNewswire-FirstCall/ --
Aastrom Biosciences, Inc. (NASDAQ:ASTM) announced today the
initiation of a new bone grafting clinical trial sponsored by
Fundacion Teknon and ITRT (Institut de Terapia Regenerativa
Tisular) at Hospital de Barcelona S.C.I.A.S., Hospital General de
l'Hospitalet and Centro Medico Teknon located in Barcelona, Spain.
The Phase I/II multi-center clinical trial has been approved by the
Spanish Drug Agency (AEMPS) and is designed to further demonstrate
the safety and effectiveness of the Company's Tissue Repair Cells
(TRCs) to regenerate new, healthy bone in the repair of long bone
fractures. This study follows a successful pilot trial that
included 5 patients conducted by the same clinical investigators,
and will incorporate various procedure modifications learned from
prior studies. The refinements are targeted at determining an
improved TRC procedure to provide more uniform use at different
clinical sites. "This trial is significant on several levels," said
R. Douglas Armstrong, Ph.D., Chief Executive Officer and Chairman
of Aastrom. "On a regulatory level, the approval we have received
from the AEMPS indicates that we have met the new stringent
requirements that have been set in place by the recent adoption of
the new clinical trial directive in the EU for cell product
clinical trials." Dr. Armstrong continued, "In addition, our
ability to further refine our clinical protocol regarding the
methodology of our TRC treatment constitutes further progress and
resolution in our product development program." The new trial will
enroll a maximum of 10 patients who will be treated for
non-hypertrophic pseudoarthrosis of long bones, or failure of a
fracture to heal properly. After treatment, patients will be
monitored over 24 months for callus and bridge formation at the
fracture site, as determined radiographically and by CT scan. The
Study Coordinator for this clinical trial is Dr. Carlos
Solano-Puerta of ITRT, and the Principal Investigators are Dr.
Lluis Orozco (Hospital de Barcelona S.C.I.A.S.), Dr. Joan Giros
Torres (Hospital General de l'Hospitalet) and Dr. Robert Soler
(Centro Medico Teknon). About Tissue Repair Cells Tissue Repair
Cells (TRCs) are Aastrom's proprietary mixture of bone
marrow-derived adult stem and progenitor cells produced using
patented single- pass perfusion technology in the
AastromReplicell(R) System. The clinical procedure begins with the
collection of a small sample of bone marrow from the patient's hip
in an outpatient setting. TRCs are then produced in the automated
AastromReplicell System over a 12-day period. It has been
demonstrated in the laboratory that TRCs are able to develop into
different types of tissue lineages in response to inductive
signals, including blood, bone, cartilage, adipose and vascular
tubules. In previous clinical trials, TRCs have been shown to be
safe and reliable in regenerating certain normal healthy bone
marrow tissues. About Aastrom Biosciences, Inc. Aastrom
Biosciences, Inc. is developing patient-specific products for the
repair or regeneration of human tissues, utilizing the Company's
proprietary adult stem cell technology. Aastrom's proprietary
Tissue Repair Cells (TRCs), a mix of bone marrow-derived adult stem
and progenitor cells for tissue regeneration, are manufactured in
the AastromReplicell(R) System, an industry- unique automated cell
production system. Aastrom's TRC cell products are in clinical
trials for the following therapeutic indications: severe bone
fractures (US: Phase I/II - multi-center; EU: Phase I/II -
multi-center), ischemic vascular disease (EU: Phase I/II), jaw
reconstruction (EU: proof of concept) and spine fusion (US: Phase
I/II - single-center). For more information, visit Aastrom's
website at http://www.aastrom.com/. This document contains
forward-looking statements, including without limitation,
statements concerning planned clinical trials, product development
objectives, potential advantages of TRCs, and potential product
applications, which involve certain risks and uncertainties. The
forward-looking statements are also identified through use of the
words "expected," "planned," and other words of similar meaning.
Actual results may differ significantly from the expectations
contained in the forward-looking statements. Among the factors that
may result in differences are potential patient accrual
difficulties, clinical trial results, potential product development
difficulties, the effects of competitive therapies, regulatory
approval requirements, the availability of financial and other
resources and the allocation of resources among different potential
uses. These and other significant factors are discussed in greater
detail in Aastrom's Annual Report on Form 10-K and other filings
with the Securities and Exchange Commission. CONTACTS: Kris M. Maly
or Cameron Associates Becky Anderson Kevin McGrath - Institutions
Investor Relations Department Phone: (212) 245-4577 Aastrom
Biosciences, Inc. Alyson Nikulicz - Media Phone: (734) 930-5777
Phone: (212) 554-5464 DATASOURCE: Aastrom Biosciences, Inc.
CONTACT: Kris M. Maly or Becky Anderson, Investor Relations
Department of Aastrom Biosciences, Inc., +1-734-930-5777; or Kevin
McGrath - Institutions, +1-212-245-4577, or Alyson Nikulicz -
Media, both of Cameron Associates, +1-212-554-5464 Web site:
http://www.aastrom.com/
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