Aurinia Pharmaceuticals Announces Recently Granted Nanomicellar Formulation Patents in Japan & China for Topical Ophthalmic A...
04 February 2015 - 12:06PM
Business Wire
Aurinia Pharmaceuticals Inc. (the “Company”) (NASDAQ:AUPH /
TSX:AUP) today announced that the Company has recently been granted
patents by the Japanese and Chinese patent offices for its
nanomicellar formulation of voclosporin. These are in addition to
multiple other patents that have been issued and granted in the
United States, Mexico and Australia for ophthalmic administration
of voclosporin. Further patent prosecution in other regions is
ongoing.
“We are very excited about the potential for ocular
administration of voclosporin utilizing this unique nanomicellar
drug delivery technology. This formulation enables high
concentrations of voclosporin to be put into solution for local
delivery to the ocular surface” said Stephen Zaruby, President
& CEO of Aurinia Pharmaceuticals Inc.
Completed preclinical and phase I studies using this
nanomicellar technology in combination with voclosporin have shown
encouraging results in terms of delivery of active drug to target
tissues. In addition this nanomicellar formulation of voclosporin
has the potential to improve dosing frequency and tolerability.
“Ophthalmic nanomicellar voclosporin has the potential to
compete in the billion dollar prescription dry eye market currently
dominated by Restasis® (Cyclosporin ophthalmic emulsion 0.05%) with
what appears to be a very competitive product profile” said Neil
Solomons, MD, Chief Medical Officer of Aurinia Pharmaceuticals
Inc.
“The Company plans to review its strategic options as it relates
to this ophthalmic formulation of voclosporin and the nanomicellar
delivery technology including but not limited to outlicensing or
divestiture while at the same time remaining focused on our lupus
nephritis program” said Mr. Zaruby.
About Aurinia
Aurinia is a clinical stage pharmaceutical company focused on
the global nephrology market. It is currently enrolling patients in
its Phase 2b clinical trial to evaluate the efficacy of its drug,
voclosporin, as a treatment for lupus nephritis (“LN”). LN is an
inflammation of the kidneys, that if inadequately treated can lead
to end-stage renal disease, making LN a serious and potentially
life-threatening condition.
Voclosporin is a novel and potentially best in class calcineurin
inhibitor (“CNI”) with extensive clinical data in over 2,600
patients in other indications. Voclosporin is made by a
modification of a single amino acid of the cyclosporine molecule (a
CNI approved for use in transplant patients since 1983). This
modification results in a more predictable pharmacokinetic and
pharmacodynamic relationship, an increase in potency vs.
cyclosporine, an altered metabolic profile, and potential for flat
dosing.
Aurinia also has development and commercialization partners in
Canada, Israel, South Africa and Greater China. Visit
www.auriniapharma.com, www.sedar.com and www.sec.gov for more
information.
About Restasis®
Restasis® (cyclosporin ophthalmic emulsion 0.05%) was approved
by the U.S. Food and Drug Administration in December 2002 to
increase tear production in patients whose tear production is
presumed to be suppressed due to ocular inflammation associated
with chronic dry eye.
Restasis® is a registered trademark of Allergan Inc.
Company:Aurinia Pharmaceuticals Inc.Stephen Zaruby,
250-708-4293President & Chief Executive Officerszaruby@auriniapharma.comorMichael R. Martin,
250-708-4272Chief Operating Officermmartin@auriniapharma.com
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