RNS Number:2080K
Osmetech PLC
22 April 2003



                        BLOCK LISTING SIX MONTHLY RETURN



AVS No:

1.         Name of company Osmetech plc
2.         Name of scheme Osmetech plc Enterprise Management Incentive Plan
3.         Period of return: From 21/10/02 to 21/04/03
4.         Number and class of share(s) (amount of stock/   47,123,595
           debt security) not issued under scheme
5.         Number of shares issued/allotted under scheme    250,000
           during period:
6.         Balance under scheme not yet issued/allotted at  46,873,595
           end of period
7.         Number and class of share(s) (amount of stock/   17,123,595 on 21/10/02
           debt securities) originally listed and the date
           of admission;                                    30,000,000 on 11/3/03
1.         Name of company Osmetech plc
2.         Name of scheme: Individual Option Arrangements
3.         Period of return: From 21/10/02 to 21/04/03
4.         Number and class of share(s) (amount of stock/   36,513,430
           debt security) not issued under scheme
5.         Number of shares issued/allotted under scheme    81,000
           during period:
6.         Balance under scheme not yet issued/allotted at  36,432,430
           end of period
7.         Number and class of share(s) (amount of stock/   36,513,430 on 21/10/02
           debt securities) originally listed and the date
           of admission;


1.         Name of company Osmetech plc
2.         Name of scheme: pursuant to the exercise of warrants by GEM
3.         Period of return: From 21/10/02 to 21/04/03
4.         Number and class of share(s) (amount of stock/   1,030,000
           debt security) not issued under scheme
5.         Number of shares issued/allotted under scheme    0
           during period:
6.         Balance under scheme not yet issued/allotted at  1,030,000
           end of period
7.         Number and class of share(s) (amount of stock/   1,030,000 on 21/10/02
           debt securities) originally listed and the date
           of admission;


1.         Name of company Osmetech plc
2.         Name of scheme: pursuant to the exercise of warrants by True North
3.         Period of return: From 21/10/02 to 21/04/03
4.         Number and class of share(s) (amount of stock/   15,000,000
           debt security) not issued under scheme
5.         Number of shares issued/allotted under scheme    0
           during period:
6.         Balance under scheme not yet issued/allotted at  15,000,000
           end of period
7.         Number and class of share(s) (amount of stock/   15,000,000 on 21/10/02
           debt securities) originally listed and the date
           of admission;


Contact for queries:                          Address:
Name: Sally Craig                             Electra House, Electra Way, Crewe, CW1 6WZ
Telephone: 01270 216444



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