International stocks trading in New York were mostly lower Monday.

The BNY Mellon index of American depositary receipts fell 0.43% to 144.95. The European index eased 0.40% to 143.05, the Asian index fell 0.67% to 153.34, the Latin American index rose 0.48% to 213.89 and the emerging markets index edged down 0.17% to 261.00. Deutsche Bank AG (DB, DBK.XE) was among the companies with ADRs that traded actively.

ADRs of Deutsche Bank rose nearly 5% to $32.15 on Monday, a day after the German bank named John Cryan as its new chief executive, succeeding co-chief executives Anshu Jain and Jurgen Fitschen. Mr. Cryan, the former UBS AG executive and Deutsche Bank board member, faces the challenge of cutting costs and reshaping relations with regulators on both sides of the Atlantic.

ADRs of Diageo PLC (DEO, DGE.LN) fell 2.8% to $114.70 on Monday as several analysts voiced skepticism regarding rumors that Brazilian private-equity firm 3G Capital Partners LP was considering making an offer for U.K based Diageo--the world's biggest liquor company by sales. ADRs of Anheuser-Busch InBev NV (BUD, ABI.BT), in which 3G Capital Partners owns a stake, declined 3.1% to $120.59.

ADRs of Shire PLC (SHPG, SHP.LN) fell 2.9% to $244.13 on Monday following a newspaper report that the Dublin-based drug maker had made an informal approach to Switzerland-based biopharmaceutical company Actelion Ltd. (ALIOY, ATLN.VX) but had been rebuffed.

ADRs of Syngenta AG (SYT, SYNN.VX) fell 1.7% to $86.81 on Monday after the Basel-based agribusiness again rejected rival Monsanto Co.'s roughly $45 billion takeover offer and derided as paltry the U.S. company's proposal to pay Syngenta a $2 billion reverse breakup fee if regulators block the deal.

The chief executive of Telecom Italia SpA (TI, TIA, TIT.MI) said the company expects to use the proceeds from the planned initial public offering of its domestic wireless-tower unit Inwit to partially pay down its debt and to invest in ultra-fast fixed and mobile broadband infrastructure. ADRs rose two cents to $12.73.

Write to Tess Stynes at tess.stynes@wsj.com

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