Bruker Daltonics Launches the Fastest & most Flexible MALDI-TOF/TOF Mass Spectrometer with Unsurpassed Performance in Proteomics
27 April 2009 - 8:00PM
Business Wire
Bruker Daltonics today launches its next-generation
ultrafleXtreme� MALDI-TOF/TOF mass spectrometer, the only
instrument combining true 1�kHz speed in both TOF and TOF/TOF modes
with ultra-high performance and extreme flexibility for a broad
variety of complementary research, clinical and applied proteomics
applications. In proteomics, MALDI-TOF/TOF is highly complementary
to ESI-MS/MS with Bruker�s latest high-capacity ion traps with ETD,
and to ultra-high resolution (UHR) ESI-Q-q-TOF maXis�
systems, as both MALDI and ESI are required for highest coverage
and flexibility in modern protein analysis.
The new ultrafleXtreme incorporates key inventions,
Bruker�s proprietary smartbeam-II� laser technology at 1
kHz, and the latest ion optics innovations. It is the only
MALDI-TOF/TOF instrument that truly enables high-throughput 1 kHz
biomarker discovery and quantitation, as well as fast,
high-performance tissue molecular imaging with a laser spot size
close to single cell spatial resolution. LC-MALDI can be performed
with unmatched mass resolution, mass accuracy and data acquisition
speed. Bruker�s unique Edmass� protein sequencing
capabilities allow very rapid and sensitive intact protein
characterization and sequencing with read lengths up to and beyond
80 residues, and with direct analysis of N- and C- terminal
modifications.
Industry-leading TOF/TOF technology is incorporated into the
ultrafleXtreme for unprecedented capabilities:
- The novel full 1�kHz
smartbeam-II laser enables ultra-high data acquisition speed in
both MS and MS/MS at full systems performance. The
well-established proprietary smartbeam laser provides
unprecedented analytical and matrix flexibility in workflows from
protein tissue imaging, intact proteins analysis, biologics or
oligo QC, to LC-MALDI proteomics - all fully enabled at 1-1000 Hz
repetition rates.
- Broadband mass resolving
power up to 40,000 enables precision proteomics via Bruker�s
unique PAN� technology for highest mass resolution across a
very broad mass range, not just at a selected optimum.
- The novel
FlashDetectorTM combined with a new 4 GHz
digitizer and latest advances in electronics provide
unmatched mass resolving power up to 40,000 and 1 ppm
mass accuracy for highest confidence.
- Bruker�s patented
smartbeam technology is already widely accepted as the most
viable MALDI imaging laser technology. The ultrafleXtreme
now enables laser focus diameters down to 10��m for
high spatial resolution imaging without pixel overlap. Importantly,
outstanding spectral quality and signal intensity are maintained at
even the smallest laser beam diameters.
- The novel and unique
laser-irradiation self-cleaning MALDI Perpetual� Ion Source
ensures robust, long-term highest-performance operation. Very long
MALDI laser lifetime in combination with automated source cleaning
in just minutes leads to high uptime and low maintenance
costs.
Efficient data retrieval and interpretation is provided by
fully integrated software platforms designed,
progressed and supported by Bruker with leading proteomics experts,
for:
- ProteinScape��2.0 ensures
confident information from quantitative studies using either
label-free or ICPL�-4plex, SILAC, iTRAQ�-8plex or
user-defined label technologies, integrates multiple datasets
across large proteomic studies and generates reports in accordance
to standard publication guidelines.
- BioTools��3.2 is the
market-leading bioinformatics platform, now extended to top-down
protein sequencing for recombinant protein work, e.g. in
biotherapeutics and biosimilars characterization and QC.
- flexImaging� 2.1 is the
true gold standard in biomarker discovery based on MALDI tissue
molecular imaging and is fully compatible with clinical
histology.
Bruker Daltonics Executive Vice President Dr. Ian Sanders
commented: �Its incredible flexibility and unparalleled performance
make the truly innovative ultrafleXtreme the definitive
MALDI-TOF/TOF today. Researchers are enabled for new achievements
in proteomics and MALDI imaging, while achieving result quality
across the board that would have been undreamed of even a short
time ago.�
The capabilities of the new ultrafleXtreme� will be
highlighted at Bruker's Annual Users Meeting on Sunday, May 31st,
2009 before the 57th ASMS Conference on Mass Spectrometry in
Philadelphia, PA. For more information on this event, please visit
www.bdal.com/asms2009. For further product information please visit
www.bdal.com/ultrafleXtreme.
ultrafleXtreme, ProteinScape, PAN, smartbeam, FlashDetector,
MALDI Perpetual, BioTools, ProteinScape, FlexImaging are trademarks
of Bruker Daltonik GmbH. ICPL is a trademark of TopLab GmbH, and
iTRAQ is a trademark of Applied Biosystems.
About Bruker Daltonics: For more information about Bruker
Daltonics and Bruker Corporation (NASDAQ: BRKR), please visit
www.bdal.com and www.bruker.com.
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