At the 61st ASMS Conference on Mass Spectrometry and Allied
Topics, Bruker today announced mass spectrometry-based product
introductions for life-science and clinical research, for
biotech/pharma/CRO customers, as well as for industrial and applied
markets. The new mass spectrometry systems and solutions are
designed to deliver confident analyses with dramatically enhanced
resolution, sensitivity and precision.
This is the new ParaCell for the Bruker
solariX XR System. (Photo: Business Wire)
The analytical utility of extreme performance will be presented
in Bruker’s users’ symposium, breakfast workshops, and hospitality
suite with emphasis on the following market/applications areas:
systems biology, proteomics and metabolomics; biologics &
pharmaceuticals; MALDI molecular imaging for pathology research and
drug development; petroleomics, energy and industrial applications;
applied markets including food, forensics and environmental
analysis; as well as MALDI Biotyper-based clinical
microbiology.
New Bruker products introduced at ASMS 2013 include:
SolariX™ XR:
With the scientifically acclaimed ParaCell™ as its core
technology, the solariX XR FTMS (Fourier Transform Mass
Spectrometry) system is redefining the way researchers approach
chemical analysis by utilizing the concept of eXtreme Resolution
throughout a wide variety of analytical workflows. Combining the
ParaCell with advanced processing technology enables the solariX XR
to provide resolving powers of greater than 650,000 in a 1 second
acquisition (at m/z 400) for routine LC/MS or MALDI imaging
experiments, and ultimately over 10 million resolving power for the
most challenging complex mixture applications, from top-down
proteomics, to petroleomics and dissolved-organic matter (DOM)
analysis, to eXtreme Resolution MALDI imaging. This is a powerful
advance in the state-of-the-art of mass spectrometry and provides
access to previously hidden insights, and to chemical information
never accessible before with mass spectrometry. For the first time,
chemists can ‘read’ the specific molecular formula for detected
compounds from the eXtreme Resolution mass spectrum - essentially
with certainty. This concept is especially relevant for
metabolomics or workflows where information about the chemical
genesis of a compound is not known, quantities available are not
sufficient for other analytical methods, and all high-sensitivity
information must be determined from mass spectral data alone.
Dr. Charles Cheng of Pfizer’s Development Analytical division
commented: “The isotopic fine structure that is easily revealed by
the extreme resolution of the new solariX XR is of tremendous value
for structural elucidation on unknowns. This fundamentally new
ability to gain complete confidence in assignment of elemental
formula perfectly complements our internal NMR activities at
Pfizer. MALDI –FTMS was also surprisingly useful for small molecule
analysis, enabling rapid high-throughput screening for
statistically based impurity analysis at extreme resolution.”
This novel eXtreme resolution platform is made easily applicable
to a wide variety of applications by leveraging the Bruker
portfolio of industry-leading MS analysis software solutions and
ionization sources, such as CaptiveSpray for robust,
high-sensitivity capillary and nano-flow applications. The solariX
XR features an advanced dual-source ion funnel which allows
effortless (~5s) changeover from API (ESI or APCI) to MALDI, thus
enabling workflows such as MALDI imaging, automation for
high-throughput screening (96–384 well targets) and top-down MALDI
sequencing to supplement ETD and ECD sequencing of large
biomolecules. The robust ion optics design of solariX XR combined
with intuitive FTMSControl software results in a user interface
that allows effortless, record-breaking performance. Advanced
processing and mining of information-rich data sets is performed
automatically and on-the-fly using Bruker applications platforms
including: new flexImaging 4.0 for MALDI imaging, ProfileAnalysis
for statistical treatment of complex data sets, and DataAnalysis
with SmartFormula XR for automated interpretation of isotopic fine
structure for exact elemental formula determination.
Impact™ HD and CaptiveSpray™ NanoBooster™
Source:
The new Impact HD is the latest innovation in Bruker’s unique
UHR-QqTOF (Ultra-High Resolution Qq-Time-Of-Flight) mass
spectrometry product line with industry-leading >40,000
Full-Sensitivity Resolution (FSR). It opens up enhanced analytical
performance levels for all applications where trace analysis from
complex, high-background matrices is a challenge – such as
biomarker research, identification of impurities or residue
screening.
Thanks to its extreme sensitivity, broad mass-transfer ion
optics and the fastest 50 Gbit/sec sampling technology, a dynamic
range of 5 orders of magnitude is achieved at UHPLC speeds, with up
to 50 Hz MS/MS capabilities. This is a prerequisite for
high-resolution, accurate mass detection of low abundance compounds
in nano- and UHPLC peaks.
Moreover, the Impact HD comes equipped with unique Instant
Expertise™ software: intelligent self-optimizing MS/MS acquisition
establishes optimal experimental conditions that are independent of
sample amount or complexity. This translates into higher
productivity and expert-caliber results - the first time!
In combination with the impact HD, Bruker also introduces the
novel CaptiveSpray nanoBooster™ for new performance levels in
proteomics and glycoanalysis. This newest version of Bruker’s
highly regarded CaptiveSpray ion source with proprietary
dopant-enriched ionization boosts nano-flow sensitivity, and drives
up protein and peptide ID rates significantly. The emphasis of
higher charge states and its sensitivity gain also provide highest
ETD sensitivity with Bruker’s amaZon ETD ion trap mass
spectrometer, and allow for the analysis of low-level glycopeptides
that were previously not measurable.
“Highest dynamic range really is compelling for proteomics
analysis when it can genuinely be delivered at UHPLC speeds,”
commented Dr. Carsten Bässmann, Bruker’s Head of ESI Applications
Development. “At ASMS 2013, we can for this first time show the
unique identification of more than 8,440 proteins at a low false
discovery rate (FDR) below 1%, in a proteomics sample, using an
integrated workflow combining 2D-LC separations with a CaptiveSpray
nanoBooster™ source on our new impact HD system.”
EVOQ™ Elite ER:
The new EVOQ Elite ER highlights the premiere of LC/MS/MS
triple-quadrupole (TQ) technology from Bruker at ASMS. The new EVOQ
Elite ER is the latest addition to the EVOQ family of LC-TQ
systems, with an extended mass range to 2,000 m/z, for peptide
quantitation or other high m/z applications.
The EVOQ LC-TQ platform features major innovations:
- the industry’s first Vacuum-Insulated
Probe (VIP™) heated electrospray ionization (HESI) source preserves
and ionizes thermally fragile molecules without discrimination and
with outstanding sensitivity
- the Active Exhaust atmospheric pressure
ionization source with a robust orifice vacuum interface
significantly enhances quantitative robustness for difficult
samples
- flat-tuning, proprietary Interlaced
Quadrupole Dual Funnel (IQ-DF™) maximizes sensitivity
- Bruker’s patented lens-free triple-quad
mass filter design enhances MRM ease and performance
- novel PACERTM software enables
exception-based data-review, a revolutionary feature that
significantly reduces the error rate for quantitative
analysis;
All EVOQ LC-TQ systems incorporate Bruker’s new Advance™
Ultra-High Pressure Liquid Chromatography (UHPLC) systems. The
Advance HPLC, UHPLC, and the UHPLC-OLE (on-line extraction)
products offer ultra-low dead volume, which enables excellent
reproducibility at analytical flow-rates, an integrated
column-oven, and bench-space savings. Paired with the
industry-leading CTC auto-sampler, the EVOQ LC-TQ delivers the
precision and accuracy required for sustained, high-sensitivity
LC-MRM quantitative analysis.
Rohan Thakur, Ph.D., Vice President and General Manager of
Bruker’s Quadrupole MS Business, stated: “The debut of the EVOQ
LC-TQ at ASMS marks the first time that Bruker has brought LC
triple quad technology to the premiere meeting for mass
spectrometry. The key innovations in the EVOQ systems are designed
to erase the pain points in today’s high volume applied markets
laboratories. Laboratories supporting food testing (pesticide
residues or adulterants), environmental labs (industrial pollutants
or personal care products), or toxicology (drug testing/doping,
pain management) will benefit from the superior performance of the
EVOQ family. Bruker’s commitment to driving Innovation with
Integrity is not just a tagline, it is our core philosophy.”
Please join Bruker at its ASMS booth #110, and at Bruker’s ASMS
press conference on Monday, June 10th, 2013 at 9:30 am to 10:30 am
CDT at the Minneapolis Hilton Hotel, Conrad Room D (breakfast
served, by registration only).
ABOUT BRUKER CORPORATION (NASDAQ: BRKR)
Bruker is a leading provider of high-performance scientific
instruments and solutions for molecular and materials research, as
well as for industrial, diagnostics and applied analysis. For more
information: www.bruker.com
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