Bruker Launches High-Throughput MALDI Biotypersmart System with Lifetime Laser
27 April 2015 - 9:00PM
Business Wire
At the 25th European Congress of Clinical Microbiology and
Infectious Diseases (ECCMID), Bruker today announced the
introduction of the MALDI Biotypersmart (MBTsmart), a
new high-throughput option in the MALDI Biotyper product family of
bench-top MALDI-TOF mass spectrometry systems for microbiology
laboratories. The MBTsmart is IVD-CE labeled
according to EU directive EC/98/79, and fully integrated with the
new IVD MALDI Sepsityper workflow for rapid microbial
identification from positive blood cultures.
The new MALDI Biotypersmart is equipped with
Bruker’s proprietary smartbeamTM solid-state laser,
which increases the laser lifetime by an order of magnitude. In
practice, this makes the smartbeam laser essentially a
‘lifetime’ laser for most microbiology applications and typical
sample throughputs today. Smartbeam is a Bruker-proprietary
laser technology which combines the higher speed and lifetime of a
solid-state laser with the analytical MALDI performance of a
nitrogen laser.
The MALDI Biotypersmart also features a more than
three times higher laser repetition rate for even faster
Time-to-Result (TTR), which often is crucial in clinical
microbiology. It also enables higher throughput during peak demand
times in the clinical microbiology laboratory, e.g. in the
mornings.
The higher speed and lifetime make the new
MBTsmart more future-proof by providing the higher
throughput that will be beneficial to implement additional
workflows going forward. For example, it facilitates additional
research applications, like sub-typing, or the emerging family of
Bruker-proprietary Selective Testing of
Antibiotic Resistance (MBT-STAR) assays, which use
the MALDI Biotyper platform for functional resistance testing of
bacteria, initially for beta-lactamase activity. High quality
subtyping or MBT-STAR assays, with QC comparisons, are expected to
require approximately an order of magnitude more laser shots than
identification.
The MALDI Biotypersmart is also equipped with a
higher performance vacuum system. This enables flexible and
convenient workflows in laboratories where multiple users are
working on the same instrument, and have the need to exchange MALDI
target plates with a minimum delay. The modified design allows
reaching high vacuum faster after preventive maintenance or
service, thus even further increasing instrument availability.
Dr. Edwin Boel, Consultant Microbiologist at University Medical
Center Utrecht, The Netherlands, explained: “We have been using the
MALDI Biotyper system for microbial identification in our routine
laboratory for years. But we also envision additional workflows
like direct analysis from positive blood cultures, and MALDI
Biotyper-based selective testing of antibiotic resistance. Even
nucleic acid analysis on MALDI-TOF mass spectrometry might become
of interest for the microbiology laboratory in the future. In
summary, we are convinced that MALDI-TOF mass spectrometry will
have even broader impact on microbiology laboratories in the
future. The new MBTsmart provides the hardware
improvements to be future-proof for such new workflows.”
Dr. Wolfgang Pusch, Executive Vice President for Clinical MALDI
at Bruker Daltonics, added: “Bruker is dedicated to innovation and
workflow improvements in clinical microbiology, in order to provide
more and better information with dramatically shorter TTRs and
higher throughput to infectious disease clinicians. This enables
our customers to reduce healthcare costs, improve antibiotic
stewardship, and improve patient comfort and outcomes. Since the
introduction of the MALDI Biotyper, Bruker has led the
MALDI-revolution in microbial identification. With the introduction
of the MALDI Biotypersmart, Bruker is now taking
MALDI-TOF mass spectrometry to the next level in the microbiology
laboratory. The MALDI Biotypersmart system is a new
high-end option for those customers who seek further increases in
throughput, convenience and flexibility in the laboratory. Higher
throughput, speed and laser lifetime facilitate additional
workflows for developing the MBT platform more and more into a
general microbiology workhorse for multiple diagnostic and
analytical tasks.”
About the Bruker MALDI Biotyper
The MALDI Biotyper family of systems enables molecular
identification, and taxonomical classification or de-replication of
microorganisms like bacteria, yeasts and fungi. Classification and
identification of microorganisms is achieved reliably and quickly
using proteomic fingerprinting by high-throughput MALDI-TOF mass
spectrometry. The MALDI Biotyper uses a molecular approach based on
specific proteomic fingerprints from bacterial strains and
published studies have highlighted the greater accuracy and lower
cost offered, as well as the much faster time-to-result (TTR).
Applications of the various MALDI Biotyper solutions include
clinical routine microbial identification, environmental and
pharmaceutical analysis, taxonomical research, food and consumer
product safety and quality control, as well as marine microbiology.
In many European and international laboratories the MALDI Biotyper
has replaced classical biochemical testing for bacterial
identification in the past seven years due to the accuracy, speed,
extensive species coverage, ease of use and cost effectiveness of
the system. Classical biochemical techniques detect different
metabolic properties of microorganisms, can take many hours or even
days for completion, and they often lack specificity.
The robust MALDI Biotyper method requires minimal sample
preparation and offers low consumables cost. The products of the
MALDI Biotyper family are available in a research-use-only (RUO)
version, as the U.S. FDA-cleared MALDI Biotyper CA System, or in an
IVD-CE version according to EU directive EC/98/79. The MALDI
Biotyper also has medical device registrations in numerous other
countries. RUO versions of the MALDI Biotyper even allow selected
high-value antimicrobial resistance tests in translational
research.
About Bruker Corporation (NASDAQ: BRKR)
For more than 50 years, Bruker has enabled scientists to make
breakthrough discoveries and develop new applications that improve
the quality of human life. Bruker’s high-performance scientific
research instruments and high-value analytical solutions enable
scientists to explore life and materials at molecular, cellular and
microscopic levels.
In close cooperation with our customers, Bruker is enabling
innovation, productivity and customer success in life science
molecular research, in applied and pharma applications, in
microscopy, nano-analysis and industrial applications, as well as
in cell biology, preclinical imaging, clinical research,
microbiology and molecular diagnostics. For more information,
please visit: http://www.bruker.com.
Investor Contact:Bruker CorporationJoshua Young, +1
978-667-9580, ext. 1479Vice President, Investor
Relationsjoshua.young@Bruker.comorMedia Contact:Bruker
Daltonics DivisionDr. Winfried Busch,
+49-421-2205-1242Winfried.Busch@bruker.com
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