EXPLANATORY NOTE
Organovo Holdings, Inc. (the Registrant) has prepared this Registration Statement in accordance with the requirements of Form S-8 under the Securities Act to register 900,000 additional shares of Common Stock issuable pursuant to the 2012 Plan, which includes 149,046 shares of Common Stock issuable upon exercise of outstanding options
granted pursuant to the 2012 Plan.
The Registrants stockholders previously approved the 2012 Plan, including the 327,699 shares of
Common Stock initially available for issuance pursuant thereto, on October 17, 2012. On August 21, 2013, the Registrants stockholders approved an amendment to the 2012 Plan to increase the number of shares of Common Stock issuable
under the 2012 Plan by 250,000 shares. On August 20, 2015, the Registrants stockholders approved an amendment to the 2012 Plan to, among other things, increase the number of shares of Common Stock issuable under the 2012 Plan by 300,000
shares. On July 26, 2018, the Registrants stockholders approved an amendment to the 2012 Plan to, among other things, increase the number of shares of Common Stock issuable under the 2012 Plan by 550,000 shares. On October 5, 2021,
the Registrants stockholders approved an amendment to the 2012 Plan to, among other things, increase the number of shares of Common Stock issuable under the 2012 Plan by 900,000 shares.
Pursuant to the Registration Statement on Form S-8 (File No. 333-181324) filed by the Registrant
with the Securities and Exchange Commission (the Commission) on May 11, 2012 (the 2012 Registration Statement), the Registrant previously registered 327,699 shares of Common Stock under the 2012 Plan. The Registrant also
filed: (i) a Registration Statement on Form S-8 (File No. 333-192248) with the Commission on November 8, 2013 (the 2013 Registration
Statement), pursuant to which the Registrant registered 250,000 additional shares of Common Stock issuable pursuant to the 2012 Plan, (ii) a Registration Statement on Form S-8 (File
No. 333-209395) with the Commission on February 4, 2016, pursuant to which the Registrant registered 300,000 additional shares of Common Stock issuable pursuant to the 2012 Plan (the 2016 Registration Statement), and
(iii) a Registration Statement on Form S-8 (File No. 333-226839) with the Commission on August 14, 2018, pursuant to which the Registrant registered
550,000 additional shares of Common Stock issuable pursuant to the 2012 Plan (the 2018 Registration Statement and together with the 2012 Registration Statement, the 2013 Registration Statement and the 2016 Registration Statement, the
Prior Registration Statements).
All share amounts in this Registration Statement give effect to the 1-for-20 reverse stock split of the Common Stock effected on August 18, 2020.
In accordance with General Instruction E to Form S-8, the contents of the Prior Registration
Statements are hereby incorporated by reference.