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| Holder | Type | Held (Actual) | % of Outstanding | Market Value | Date Reported |
|---|---|---|---|---|---|
| RTW Investments, LP | Institution | 6,574,032 | 5.85% | US$ 125.89M | 2026-03-31 |
| TCG Crossover Management, LLC | Institution | 5,913,075 | 5.26% | US$ 113.24M | 2026-06-02 |
| FMR LLC | Institution | 5,770,011 | 5.14% | US$ 110.50M | 2026-06-17 |
| RA Capital Healthcare Fund, L.P. | Institution | 5,740,762 | 5.11% | US$ 109.94M | 2026-03-31 |
| RA Capital Management, L.P. | Institution | 5,707,262 | 5.08% | US$ 109.29M | 2026-03-31 |
| Qiming Weichuang Venture Capital Management (Shanghai) Company Limited | Institution | 4,888,364 | 4.35% | US$ 93.61M | 2025-12-31 |
| Qiming Venture Partners Iv, L.P. | Institution | 4,738,741 | 4.22% | US$ 90.75M | 2025-12-31 |
| Norges Bank Investment Management | Institution | 3,868,017 | 3.44% | US$ 74.07M | 2025-12-31 |
| Vanguard Capital Management, LLC | Institution | 3,255,835 | 2.90% | US$ 62.35M | 2026-05-31 |
| Wellington Management Group LLP | Institution | 3,092,804 | 2.75% | US$ 59.23M | 2026-03-31 |
| TCG Crossover Fund III, L.P. | Institution | 2,956,542 | 2.63% | US$ 56.62M | 2026-06-02 |
| TCG Crossover Fund II, L.P. | Institution | 2,956,533 | 2.63% | US$ 56.62M | 2026-06-02 |
| BlackRock, Inc. | Institution | 2,799,221 | 2.49% | US$ 53.61M | 2026-06-30 |
| The Goldman Sachs Group, Inc. | Institution | 2,708,611 | 2.41% | US$ 51.87M | 2026-06-16 |
| Morgan Stanley | Institution | 2,539,942 | 2.26% | US$ 48.64M | 2026-06-15 |
| Frazier Life Sciences Management, LP | Institution | 1,902,320 | 1.69% | US$ 36.43M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 1,688,632 | 1.50% | US$ 32.34M | 2026-03-31 |
| Baron Capital Group, Inc. | Institution | 1,658,318 | 1.48% | US$ 31.76M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 1,425,367 | 1.27% | US$ 27.30M | 2026-03-31 |
| JPMorgan Chase & Co. | Institution | 1,248,614 | 1.11% | US$ 23.91M | 2026-06-15 |
| Dr. Ying Du | Insider | 1,203,784 | 1.07% | US$ 23.05M | 2026-06-30 |
| Yinhua Fund Management Co., Ltd. | Institution | 1,177,230 | 1.05% | US$ 22.54M | 2025-12-31 |
| China Universal Asset Management Company Ltd. | Institution | 1,045,395 | 0.93% | US$ 20.02M | 2026-03-31 |
| UBS Asset Management AG | Institution | 963,647 | 0.86% | US$ 18.45M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 880,173 | 0.78% | US$ 16.86M | 2026-05-31 |
| Bosera Asset Management Co., Ltd. | Institution | 853,520 | 0.76% | US$ 16.34M | 2025-06-30 |
| Rock Springs Capital Management LP | Institution | 814,707 | 0.73% | US$ 15.60M | 2026-03-31 |
| China Asset Management Co. Ltd. | Institution | 776,570 | 0.69% | US$ 14.87M | 2026-05-29 |
| Invesco Great Wall Fund Management Co. Ltd | Institution | 625,440 | 0.56% | US$ 11.98M | 2025-12-31 |
| Dimensional Fund Advisors LP | Institution | 532,710 | 0.47% | US$ 10.20M | 2026-05-29 |
| ICBC Credit Suisse Fund Management Co., Ltd | Institution | 519,970 | 0.46% | US$ 9.96M | 2025-06-30 |
| C WorldWide Asset Management Fondsmaeglerselskab A/S | Institution | 510,000 | 0.45% | US$ 9.77M | 2026-03-31 |
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