Waters New ProteinWorks Digest Kits Address Challenges of Protein Bioanalysis
20 January 2016 - 2:00AM
Business Wire
Kits Simplify Sample Preparation, Offer
Bioanalytical Scientists a Standardized Route to Fast, Accurate and
Precise Protein Quantification
Waters Corporation (NYSE:WAT) today introduced a new line of
Waters® ProteinWorks™ Digest Kits that simplify, accelerate and
standardize the LC-MS quantification of proteins via the surrogate
peptide approach. The kits are an ideal solution for laboratories
performing protein bioanalysis at innovator and biosimilar firms,
contract research organizations, disease research centers,
hospitals and university medical centers. The five kits are now
available immediately worldwide from Waters.
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Waters ProteinWorks Digest Kits simplify,
accelerate and standardize the LC-MS quantification of proteins.
The more efficient approach to protein bioanalysis enabled by the
kits, allows research to progress faster and get life-saving drugs
to market quicker. (Photo: Business Wire)
“From our collaborations with scientists, it’s clear that a
better approach to bioanalysis sample preparation is needed for
therapeutic proteins. Today's methods are fraught with variability
due to a lack of standardization,” said Mike Yelle, Vice President,
Waters Consumable Business Unit. “Our ProteinWorks Kits simplify
and standardize protein quantification workflows and shorten the
time to precise and accurate results.”
The kits are also expected to allow biopharmaceutical scientists
to more easily deploy methods to contract organizations as well as
transfer methods from one laboratory to another.
Precise Protein Digestion with ProteinWorks eXpress™ Digest
Kits
ProteinWorks eXpress Digest Kits contain pre-measured,
lot-traceable reagents, a 96-tube flexible sample collection module
and easy-to-follow protocols enabling reproducible, fast digestion
and accurate, sensitive protein quantification in both
immunopurified and whole, non-immunopurified plasma and serum
samples. The ProteinWorks product portfolio includes an optional,
optimized µElution™ SPE kit and protocol designed to increase assay
sensitivity, reduce matrix interferences, and improve LC-MS system
robustness.
The exceptional reproducibility of the ProteinWorks Kits
suggests that a high degree of intra- and inter-laboratory
standardization is achievable - making method transfer easier and
more successful.
For more information, see Waters applications note on Infliximab
in Rat Plasma describing the speed, accuracy, precision and limits
of quantification (LOQs) achievable with ProteinWorks eXpress
Digest Kit.
Protein Bioanalysis by LC-MS
Bioanalysis with liquid chromatography (LC) and mass
spectrometry (MS) determines drug concentrations in biological
fluids yielding data about the time course of a drug's action in
the body.
With emphasis on the process of getting biotherapeutic proteins
to patients faster, Waters continues to focus on the needs of
patients and improving healthcare delivery with novel pre-analytic
solutions and LC-MS instrumentation that empower laboratories to
tackle the complexity and challenges of large molecule
quantification.
For More Information
www.waters.com/proteinworks
www.waters.com/digest
About Waters Corporation
(www.waters.com)
Waters Corporation (NYSE:WAT) develops and manufactures advanced
analytical and material science technologies for laboratory
dependent organizations. For more than 50 years, the company has
pioneered a connected portfolio of separations science, laboratory
information management, mass spectrometry and thermal analysis
systems.
Waters, The Science of What’s Possible, µElution, and
ProteinWorks are trademarks of Waters Corporation.
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Waters CorporationBrian Murphy, +1-508-482-2614Corporate Public
Relationsbrian_j_murphy@waters.com
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