TIDMROQ

RNS Number : 1451J

Roquefort Therapeutics PLC

14 August 2023

14 August 2023

Roquefort Therapeutics plc

("Roquefort Therapeutics" or the "Company")

Expansion of Patent Portfolio

Successful filing of the international (PCT) patent enhances Midkine IP leadership position

Roquefort Therapeutics (LSE:ROQ), the Main Market listed biotech company focused on developing first in class medicines in the high value and high growth oncology market is pleased to announce the successful filing of the international phase PCT (Patent Treaty Cooperation) patent for its proprietary anti-cancer mRNA and RNA oligonucleotide therapeutics .

Today's announcement follows the development of the Company's novel anti-cancer RNA oligonucleotide and mRNA therapeutics targeting Midkine ("MDK") announced on 13 and 22 June 2023, which are undergoing in vitro and in vivo studies at the University of Sydney and University of New South Wales. The studies demonstrated efficacy with the Company's MDK RNA Oligonucleotides and mRNA in validated in vitro models of breast and liver cancer.

The PCT patent, governed by the World Intellectual Property Organisation (WIPO), once approved, provides patent protection for the invention in more than 155 countries [1] . The filing consolidates and enhances the Company's intellectual property portfolio and leadership position in Midkine with composition of matter and methods for the protection for both mRNA and RNA oligonucleotide modalities. While the mRNA and RNA oligonucleotides target different regions of the Midkine, both have demonstrated anti-cancer efficacy in vitro. [2]

The MDK RNA oligonucleotide and mRNA programs have now progressed into combinations studies with a proprietary targeted nano-particle delivery technology and are scheduled to progress into in vivo studies in Q4 2023.

Ajan Reginald, Chief Executive Officer of Roquefort Therapeutics, said:

"mRNA technology promises to revolutionize future treatments for cancer (AAMC [3] ) and as such we are delighted that we are part of this cutting-edge field to treat the hardest-to-treat cancers. Both the mRNA and RNA oligonucleotides attack the novel Midkine target, in which the Company are pioneers. Midkine expression is highly associated with cancer progression and poor survival.

As we've recently seen with the validation of STAT-6 (through a $Billion licensing deal), we believe Midkine will become a highly attractive, validated target and we will be uniquely positioned with a portfolio of patented antibody, mRNA and RNA oligonucleotide medicines. Therefore our focus is continue to deliver on R&D and commercial milestones that highlight the significant potential of Midkine as a novel cancer target."

-Ends-

Enquiries:

 
 Roquefort Therapeutics plc 
 Stephen West (Chairman) / Ajan           +44 (0)20 3918 
  Reginald (CEO)                                    8633 
 Hybridan LLP (Joint Broker) 
  Claire Louise Noyce 
 
  Optiva Securities Limited (Joint        +44 (0)203 764 
  Broker)                                           2341 
                                          +44 (0)20 3411 
 Christian Dennis                                   1881 
 
  Buchanan (Public Relations) 
  Ben Romney / Jamie Hooper / George      +44 (0)20 7466 
  Beale                                             5000

LEI: 254900P4SISIWOR9RH34

About Roquefort Therapeutics

Roquefort Therapeutics (LSE:ROQ) is a Main Market listed biotech company developing first in class drugs in the high value and high growth oncology segment prior to partnering or selling to big pharma.

Since listing in March 2021, Roquefort Therapeutics has successfully acquired Lyramid Pty Limited, a leader in the development of medicines for a new therapeutic target, Midkine (a human growth factor associated with cancer progression), and most recently acquired Oncogeni Ltd, founded by Nobel Laureate Professor Sir Martin Evans, which has developed two families of innovative cell and RNA oncology medicines.

Roquefort Therapeutics' portfolio consists of five fully funded, novel patent-protected pre-clinical anti-cancer medicines. The highly complementary profile of four best-in-class medicines consists of:

   --    Midkine antibodies with significant in vivo efficacy and toxicology studies; 
   --    Midkine RNA oligonucleotide therapeutics with novel anti-cancer gene editing action; 
   --    Midkine mRNA therapeutics with novel anti-cancer approach 
   --    STAT-6 siRNA therapeutics targeting solid tumours with significant in vivo efficacy; and 
   --    MK cell therapy with direct and NK-mediated anti-cancer action.

For further information on Roquefort Therapeutics, please visit www.roquefortplc.com and @RoquefortTherap on Twitter.

[1] www.wipo.int/pct

[2] https://www.roquefortplc.com/regulatory-news/39390 and https://www.roquefortplc.com/regulatory-news/39288

[3] https://www.aamc.org/news/mrna-technology-promises-revolutionize-future-vaccines-and-treatments-cancer-infectious-diseases

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