RNS Number : 8171U

Shield Therapeutics PLC

27 November 2023

Shield Therapeutics plc

("Shield Therapeutics" or the "Company")

PDMR Transaction Notification

London, UK, 27 November 2023: Shield Therapeutics plc (LSE:STX), a commercial stage pharmaceutical company with a focus on addressing iron deficiency with its lead product Accrufer(R)/Feraccru(R) (ferric maltol), confirms that Mr Hans Peter Hasler, Chairman, acquired 2,000,000 Ordinary Shares in the Company on 21 November 2023 at a price of 6.1p per share. Mr Hasler now holds a beneficial interest in 5,500,000 Ordinary Shares.

The notification below, which has been made in accordance with the requirements of the EU Market Abuse Regulation, provides further detail.

Notification and public disclosure of transactions by persons discharging managerial responsibilities and persons closely associated with them:

            1.   Details of the person discharging managerial responsibilities / person closely associated 
      a.         Name                              Hans Peter Hasler 
                --------------------------------  ------------------------------------------------------------- 
            2.   Reason for the notification 
            a.   Position/status                   Chairman 
                --------------------------------  ------------------------------------------------------------- 
            b.   Initial notification              Initial 
                --------------------------------  ------------------------------------------------------------- 
            3.   Details of the issuer, emission allowance market participant, auction platform, auctioneer 
                  or auction monitor 
            a.   Name                              Shield Therapeutics plc 
                --------------------------------  ------------------------------------------------------------- 
            b.   LEI                               213800G74QWY15FC3W71 
                --------------------------------  ------------------------------------------------------------- 
            4.   Details of the transaction(s): section to be repeated for (i) each type of instrument; (ii) 
                  each type of transaction; (iii) each date; and (iv) each place where transactions have been 
            a.   Description of the                Ordinary shares of 1.5p each in the capital of the Company 
                  Financial instrument, type 
                  of instrument 
                  Identification code 
                                                    ISIN of Ordinary Shares: GB00BYV81293 
                --------------------------------  ------------------------------------------------------------- 
            b.   Nature of the transaction         Acquisition of Ordinary Shares 
                --------------------------------  ------------------------------------------------------------- 
            c.   Price(s) and volume(s)              Price(s)   Volume(s) 
                                                      6.1p       2,000,000 
                --------------------------------  ------------------------------------------------------------- 
            d.        Aggregated information 
                        *    Aggregated volume       2,000,000 
                        *    Price 
                --------------------------------  ------------------------------------------------------------- 
            e.   Date of the transaction           21 November 2023 
                --------------------------------  ------------------------------------------------------------- 
            f.   Place of the transaction          AIM 
                --------------------------------  ------------------------------------------------------------- 

For further information please contact:

 Shield Therapeutics plc                                        www.shieldtherapeutics.com 
 Greg Madison, CEO                                                    +44 (0) 191 511 8500 
   Nominated Adviser and Joint 
 Peel Hunt LLP 
 James Steel/Patrick Birkholm                                          +44 (0)20 7418 8900 
  Joint Broker 
   Cavendish Capital Markets Ltd 
   Geoff Nash/ George Dollemore/Nigel 
   Birks                                                               +44 (0)20 7220 0563 
   Financial PR & IR Advisor 
 Walbrook PR 
 Paul McManus/ Alice Woodings                 +44 (0)20 7933 8780 or shield@walbrookpr.com 
 Investor Contact (US Advisor) 
  LifeSci Advisors, LLC 
  John Mullaly                             +1 617 429 3548 or jmullaly@lifesciadvisors.com 

About Iron Deficiency and Accrufer(R)/Feraccru(R)

Clinically low iron levels (aka iron deficiency, ID) can cause serious health problems for adults of all ages, across multiple therapeutic areas. Together, ID and ID with anemia (IDA) affect about 20 million people in the US and represent a $2.3B market opportunity. As the first and only FDA approved oral iron to treat ID/IDA, Accrufer(R) has the potential to meet an important unmet medical need for both physicians and patients.

Accrufer(R)/Feraccru(R) (ferric maltol) is a novel, stable, non-salt-based oral therapy for adults with ID/IDA. Accrufer(R)/Feraccru(R) has a novel mechanism of absorption compared to other oral iron therapies and has been shown to be an efficacious and well-tolerated therapy in a range of clinical trials. More information about Accrufer(R)/ Feraccru(R) , including the product label, can be found at: www.accrufer.com and www.feraccru.com .

About Shield Therapeutics plc

Shield is a commercial stage specialty pharmaceutical company that delivers Accrufer(R)/Feraccru(R) (ferric maltol), an innovative and differentiated pharmaceutical product, to address a significant unmet need for patients suffering from iron deficiency, with or without anemia. The Company launched Accrufer(R) in the U.S. with an exclusive, multi-year collaboration agreement with Viatris. Outside of the U.S., the Company licensed the rights to four specialty pharmaceutical companies. Feraccru(R) is commercialized in the UK and European Union by Norgine B.V. (Norgine), which also has marketing rights in Australia and New Zealand. Shield also has an exclusive license agreement with Beijing Aosaikang Pharmaceutical Co., Ltd., for the development and commercialization of Accrufer(R)/ Feraccru(R) in China, Hong Kong, Macau and Taiwan, with Korea Pharma Co., Ltd. for the Republic of Korea (Korea Pharma), and with KYE Pharmaceuticals Inc. for Canada.

Accrufer(R)/Feraccru(R) has patent coverage until the mid-2030s.

Accrufer(R)/Feraccru(R) are registered trademarks of Shield Therapeutics.

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November 27, 2023 12:24 ET (17:24 GMT)

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