boston745
4 months ago
You should research Dr Pezzotti. He was a scientist that did several studies for Biomet before joining Sintx in 2015. Hes been integral in development and testing of Si3n4 as well as a consultant for a study testing Sintx Si3n4 femoral heads against Biomets E1 liner in 2016; a decade after the last time these two companies tested their femoral head and liners together. This is an example of strategic parntership where you share resources and Dr Pezzotti is a major resource. Even recently Knighted in Italy for his contributions.
Some of Dr. Pezzotti's Biomet research for Biomet:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=174052660
========================================
Sintx 2016 10k
Together with a strategic partner, we have initiated biomechanical testing of our solid silicon nitride femoral heads. The results of this test will be released in 2017
This quote indicates the results of testing of their femoral head with a strategic partner will be released in 2017.
Those results were released testing Sintx Femoral head against Biomet's E1 liners. Thus Zimmer Biomet, or any of its subsidiaries, is Sintx strategic partner in this testing.
Amedica and Zimmer-Biomet (Tokyo Office) provided the femoral heads and acetabular liners; however, neither company actively sponsored the research
These are risk-averse companies that look to smaller companies like us to develop an idea, uh, and, uh, de-risk it, so to speak, and then buy that technology.
Quote Sources:
https://web.archive.org/web/20240408163612/https://spineblogger.blogspot.com/2011/05/whos-next.html?m=1
2016 10-k pg 13: https://www.sec.gov/Archives/edgar/data/1269026/000149315217010752/form10-k.htm
2017 results: https://ir.sintx.com/news-events/press-releases/detail/95/amedica-announces-results-of-independent-femoral-head-wear
https://web.archive.org/web/20240408152758/https://sintx.com/wp-content/uploads/2021/03/Investor-Call-Transcript-033021.pdf
boston745
4 months ago
I should add that the current Chairman, former CEO, was a member of Zimmers surgeon panel from 2002-2014+ (dont know when or if he ever stopped being part of Zimmers panel.
He joined Sintx clinical advisory panel end of 2005. That femoral head-liner study in 2007 would have occurred in 2006 just after Dr Bal joined Sintx, then Amedica. Almost as if Zimmer sent him to Amedica to help develop/give advice for testing hip/knee implants using...Biomet IP it seems. That move didnt make sense back then but obviously post merger it does.
Dr. Sonny Bal, MD
Designer Surgeon Panel, Zimmer Inc., Warsaw, Indiana, 2002 to present.
Total Joint Reconstruction Clinical Advisory Panel, Amedica Inc., Salt Lake City, UT, 2005 to present.
Zimmer Holdings, Inc.: “Comparison of tissue-engineered osteochondral grafts fabricated with mesenchymal stem cells and trabecular metal or allograft bone.” $125,406.00. 5/25/2006 to 5/24/2007.
Zimmer Holdings,Inc.: “Design and testing of a canine biological femoral head replacement.” $342,837.00. 7/1/2011 to 6/30/2014.
https://web.archive.org/web/20240316192627/https://hipandknee.com/wp-content/uploads/2014/04/Dr.-Bal-CV.pdf
boston745
4 months ago
The stock is heavily manipulated. There are some hedge funds that have been targeting the stock with a short and distort campaign for about 9 years now. I post about that on Sintx board if you want more info on that.
The stock is not a reflection of the IP however. In fact the better Sintx does, the worse the stock performs because of those funds, in part. Go figure.
Si3n4 is a material that Zimmer & Biomet have been working with for going on 20 years so this isnt just "biotech". Its specific to ZB. For instance:
2007 (ORS Annual Meeting Feb 11-14)
THERMAL CONDUCTIVITY OF FEMORAL BALL STRONGLY INFLUENCED UHMWPE WEAR IN A HIP SIMULATOR STUDY
Ten 28 mm ID isostatically moulded UHMWPE liners were investigated: GUR 1050 resin, gamma-sterilized with 25ñ40 kGy in argon (ArComô, Biomet Inc, Warsaw, IN). The liners were coupled with zirconia (Y-ZrO 2 : ProzyrÆ), cobalt-chrome (Biomet, Inc), silicon nitride (Si3 N 4 : Amedica-Inc, UT) and alumina femoral balls (Al2 O 3 : Biolox-forteÆ) (Figure 1).
Acknowledgements The authors thank Amedica, Utah, US and Biomet Inc, US for their support
Amedica became SinTx when it expanded from just ortho industry.
Quote Source:
http://c.eqcdn.com/_5c7526ae538a6086a4025ef13f5136d2/amedica/db/265/660/pdf/0278.pdf
boston745
4 months ago
That has nothing to do with the companies IP. I was just showing you why Zimmer Biomet would want the IP. It can be used on just about any material currently being used in the ortho/dental markets to bring its benefits to those materials. ZTA, Metals, PEEk, Si3n4 can imbue those materials with antimicrobial properties as well as enhance their osseointegration. Something not mentioned in the PR was the fact that coatings should reduce metal ion release into the body like indicated in this previous PR.
Composite Coating of PEKK + Silicon Nitride Successfully Applied to Ti-Alloy Substrate; Product to Address Infection Risk, Metallosis, & Bone Integration
https://ir.sintx.com/news-events/press-releases/detail/236/sintx-receives-notice-of-allowance-for-united-states-patent
Without coatings this happens:
https://i.imgur.com/nLg7SXT.jpg
boston745
4 months ago
announced that it has received a Notice of Allowance from the United States Patent and Trademark Office (USPTO) for patent application no. 17/634,141 entitled "Methods of Surface Functionalization of Zirconia-Toughed Alumina with Silicon Nitride Ceramic.”
The patent covers novel methods of bonding bioactive silicon nitride or mixtures of silicon nitride and bioactive glass to zirconia-toughened alumina (ZTA) and similar material surfaces. This invention is designed to impart silicon nitride’s beneficial biomedical properties, namely improved osseointegration and resistance to bacterial colonization, to relatively biologically inert ZTA substrates, positioning SINTX at the forefront of medical device biomaterial manufacturing.
When compounded with or applied to the surface of conventional inert biomaterials, silicon nitride’s improved osseointegration and resistance to bacterial colonization can be conferred to the resulting device. Another benefit of the coating method is that it allows for potential refinishing of existing devices to upgrade their functionality. Other filings in progress protect similar approaches to applying silicon nitride to metallic and polymeric substrates as part of SINTX’s broader strategy of expanding the applications where silicon nitride’s benefits can be realized.
More reasons for Zimmer Biomet to want this IP.
https://ir.sintx.com/news-events/press-releases/detail/236/sintx-receives-notice-of-allowance-for-united-states-patent
DewDiligence
5 months ago
ZBH reports 2Q24 results:
https://investor.zimmerbiomet.com/news-and-events/news/2024/08-07-2024-113041683
2Q24 results
• Revenue of $1.94B, +6% YoY in constant currency (+4% YoY in US dollars).
• GAAP EPS of $1.18, up from $1.00 in 2Q23.
• Non-GAAP* EPS of $2.01, up from $1.82 in 2Q23.
Updated 2024 guidance
• YoY sales growth of 5-6% in constant currency, unchanged from the guidance given three months ago.
• A (1.0%) sales headwind from exchange rates due to a stronger US dollar than anticipated in the prior guidance. I.e. YoY sales growth in US dollars is now expected to be 4-5% rather than the prior guidance of 4.5-5.5%.
• Non-GAAP* EPS of $8.00-8.15 (up from the actual $7.55 in 2023), which is unchanged from the guidance given three months ago.
2024-2027 guidance from 5/29/24 Investor Day (#msg-174509651)
• YoY sales growth of 4-6% (excluding exchange rates), equal to or slightly higher than the overall med-device market.
• YoY growth of non-GAAP* EPS at least 1.5 times the YoY sales growth (i.e. at least 6-9%).
*Non-GAAP EPS excludes restructuring costs.
DewDiligence
1 year ago
Re: GLP-1 effect on med-device companies
ZBH’s new CEO concurs with the discussion in #msg-173002788; from the 3Q23 CC transcript:
https://finance.yahoo.com/news/zimmer-biomet-holdings-inc-nyse-224434890.html …once the cartilage is damaged, there is no recovery. …dropping weight is not going to cure osteoarthritis. …If anything, obesity is a blocker today to joint surgery as many surgeons are uncomfortable operating on patients with a BMI greater than 40 [in some countries] or even above the 30 threshold in some locations.
So why could GLP-1s then be a tailwind for orthopedics? Three compelling reasons. First, if you can lower the patient’s BMI below a certain threshold… these patients now become eligible for surgery. And all the data points that we’re getting in primary markets like the U.S. is that there is a large percentage of patients who today are not going through surgery because their BMI is too high.
Secondly, if a patient does lose…weight…and…become more active, there will be a greater risk for additional joint procedures because there will be injury.
And third, if a patient loses weight, they are likely to live longer… expanding the patient’s [timeline] for an orthopedic procedure. A good example of this is Japan, the second-largest market in the world for osteoarthritis with minimal obesity rates, but very long life expectancy...
Entlarvt
2 years ago
Actually, there is no scientific evidence to support the claim that titanium blood serum levels increase by 3.5fold within one year of implantation. While titanium is commonly used in medical implants due to its biocompatibility, there is no known mechanism by which titanium implants can directly influence blood serum levels.
Titanium implants are known to integrate with surrounding tissues through a process called osseointegration, where the bone fuses with the implant. This integration occurs on a structural level, facilitating the stability and longevity of the implant. However, it does not lead to a significant alteration in blood serum composition or titanium levels within the bloodstream.
It's important to approach such claims with a critical mindset and rely on scientific studies and empirical evidence. While titanium implants have proven benefits in terms of their mechanical properties and compatibility with the human body, attributing miraculous serum level increases to titanium implants is unsupported by scientific research.
Remember, it's always best to consult reliable scientific sources and experts in the field when evaluating medical claims to ensure accurate and evidence-based information.
boston745
2 years ago
"There are many published articles supporting these views, but there is recent scientific evidence that Ti, or its corrosive by-products, may cause harmful reactions in humans. It is important for all medical and dental professionals to understand the implications, complexities, and all potential pathways of exposure to this metal"
Entlarvt
2 years ago
While it is true that some patients may experience less severe immune reactions to titanium implants, it is important to note that titanium is widely recognized as a biocompatible material with a low incidence of allergic reactions. The majority of individuals tolerate titanium implants well without any adverse effects.
Allergic reactions to titanium are considered extremely rare, and when they do occur, they tend to be localized and mild. The immune response to titanium implants is generally minimal, as titanium forms a protective oxide layer on its surface that helps prevent corrosion and immune reactions.
It is also worth mentioning that the medical field has rigorous testing and screening protocols in place to identify potential allergies or sensitivities before implanting any medical devices, including titanium implants. These pre-implantation tests, such as patch testing and laboratory investigations, help to identify individuals who may have a higher risk of adverse reactions to certain materials.
While it is possible for some patients to develop delayed sensitivities or immune reactions to titanium implants over time, it is crucial to approach such claims with scientific evidence and peer-reviewed studies. Without robust research demonstrating a widespread problem of undetected titanium allergies leading to various health issues, it would be speculative to attribute unrelated symptoms solely to titanium implants.
If individuals have concerns about their implants or suspect an allergic reaction, it is recommended to consult with healthcare professionals who can conduct proper medical evaluations and provide appropriate advice based on individual circumstances.
Entlarvt
2 years ago
While it is true that some individuals may develop sensitivities or allergic reactions to certain materials over time, such as titanium implants, it is essential to consider the available scientific evidence and expert opinions on the matter.
When it comes to titanium implants, such as those used in dental or orthopedic procedures, allergic reactions are extremely rare. Titanium is known for its biocompatibility, meaning it is generally well-tolerated by the human body and does not typically trigger immune responses or sensitivities. Titanium implants have been extensively used for many years with a high success rate and minimal adverse reactions reported.
Allergic reactions to titanium are considered uncommon, and when they do occur, they are often associated with pre-existing allergies to other metals, such as nickel or cobalt, which may be present as impurities in the titanium alloy. In such cases, it is crucial for patients to inform their healthcare providers about any known metal allergies before undergoing implant procedures.
Furthermore, thorough pre-implant testing and evaluation are typically conducted to identify potential sensitivities or allergies. This includes assessing a patient's medical history, conducting skin patch tests, and utilizing other diagnostic techniques to determine the suitability of titanium implants. These measures help to minimize the risk of adverse reactions and ensure the best possible outcome for patients.
It is important to rely on scientifically sound studies, expert opinions, and medical guidelines when evaluating the safety and potential risks associated with medical implants. While anecdotal reports and individual experiences can provide valuable insights, they should be interpreted with caution and considered in the context of broader scientific knowledge and consensus.
Entlarvt
2 years ago
The problem is you'll never know who is going to be sensitive and its a growing problem.
Allergic reactions to titanium implants are extremely rare, and with proper testing, it is easy to identify individuals who are sensitive to titanium.
Biocompatibility of Titanium:
Titanium is widely recognized as a biocompatible material, meaning it is well-tolerated by the human body. When titanium implants are surgically placed, they generally integrate smoothly with the surrounding tissues without triggering an immune response. The biocompatibility of titanium is attributed to its oxide layer, which forms naturally upon exposure to oxygen. This oxide layer acts as a protective barrier, preventing direct contact between the titanium metal and body tissues, minimizing the risk of allergic reactions.
Low Reactivity and Corrosion Resistance:
Titanium exhibits excellent corrosion resistance, ensuring the stability and longevity of implants within the body. Unlike other metals, titanium does not easily corrode or release metal ions into the surrounding tissues. This low reactivity reduces the likelihood of an immune response, minimizing the risk of allergic reactions. The stable nature of titanium implants further contributes to their biocompatibility and the rarity of adverse reactions.
Lack of Allergenic Potential:
Titanium is considered to have low allergenic potential, meaning it does not commonly elicit allergic responses in individuals. The structure and properties of titanium do not typically trigger the immune system's sensitization process, which is necessary for an allergic reaction to occur. Unlike certain metals, such as nickel or cobalt, titanium has a significantly lower sensitization rate. This inherent low allergenic potential of titanium makes allergic reactions to titanium implants highly uncommon.
Minimal Reports of Allergic Reactions:
The medical literature contains very few documented cases of true allergic reactions specifically attributed to titanium implants. The reported cases are exceedingly rare, and most of them involve individuals with pre-existing metal allergies or hypersensitivity conditions. These isolated cases indicate that while allergic reactions to titanium are theoretically possible, they occur so infrequently that they are considered outliers.
Reliable Allergy Testing:
If there are concerns about an individual's sensitivity to titanium, allergy testing can be performed. Patch testing, which involves applying small amounts of allergens to the skin, can help identify potential allergic reactions. However, it is important to note that patch testing for titanium sensitivity is not a routine procedure due to the rarity of allergic reactions. In cases where a true allergic reaction is suspected, specialized testing can be conducted to determine the specific cause of the reaction.
In summary, allergic reactions to titanium implants are extremely rare due to titanium's biocompatibility, low reactivity, and lack of allergenic potential. The minimal reports of allergic reactions, coupled with the stability and corrosion resistance of titanium implants, contribute to their overall safety and rarity of adverse responses. While allergy testing is available for individuals with specific concerns, it is not a standard practice due to the low incidence of allergic reactions to titanium.
Entlarvt
2 years ago
While it is true that some individuals may develop allergic reactions to certain materials, including metals like titanium, attributing migraines solely to an allergic reaction from a dental implant requires careful examination and consideration of scientific evidence. Here are some points to consider:
Migraine triggers: Migraines can be triggered by a variety of factors, including stress, hormonal changes, certain foods, environmental factors, and genetic predispositions. It is important to consider these potential triggers before attributing migraines solely to an allergic reaction from a dental implant.
Allergic reactions and migraines: Allergic reactions can indeed cause headaches or migraines in some individuals. However, it is crucial to establish a direct cause-and-effect relationship between the specific allergic reaction to a dental implant material and the occurrence of migraines. Migraine triggers and causes can be complex and multifactorial, and it is often challenging to isolate a single factor as the sole cause.
Prevalence of allergic reactions to dental implants: While allergic reactions to dental implant materials like titanium can occur, they are relatively rare. Titanium is generally considered highly biocompatible, and allergic reactions to it are uncommon. The incidence of true allergies to titanium implants is low, with most individuals tolerating them well.
Comprehensive diagnosis: Before attributing migraines to an allergic reaction from a dental implant, a comprehensive evaluation by healthcare professionals, such as dentists and neurologists, is necessary. This may involve ruling out other potential causes for migraines and considering a range of factors that contribute to migraine development.
Individual variations: Each person's response to dental implants or any medical device can vary. Some individuals may develop hypersensitivity or allergic reactions to specific materials, while others tolerate them without issues. Identifying an individual's specific allergic reaction and its relationship to migraines requires a thorough evaluation of medical history, diagnostic tests, and expert medical judgment.
In summary, while allergic reactions to dental implant materials can occur, attributing migraines solely to an allergic reaction from a dental implant requires careful consideration of individual circumstances, comprehensive evaluation, and scientific evidence. It is essential to consult with healthcare professionals who can provide a thorough assessment and guidance tailored to each person's unique situation.
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