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Presented at Experimental Biology Conference 2014
Sucampo Pharmaceuticals, Inc.(Nasdaq:SCMP), a global biopharmaceutical company, has announced that preclinical data for lubiprostone and unoprostone isopropyl will be presented at the Experimental Biology Society 2014 Conference in San Diego, California.
The following posters will be presented on the following dates and times in exhibit halls A-D at the San Diego Convention Center:
– Amino Acids Involved in Lubiprostone Activation of Human ClC-2 (Jayati Chakrabarti, PhD, Danuta H. Malinowska, PhD, Kirti P. Tewari, PhD, Ryuji Ueno, MD, PhD, PhD) Poster 896. Transporters: Transmitters, Nutrients, Metabolites, and Drugs Monday April 28, 12:45 PM – 3:00 PM
– Lubiprostone (a prostone) slows the in vitro growth of colon adenosarcoma cells with low (NAD+) 15-OH PGDH (J. Chakrabart, PhDi, J.Cuppoletti, PhD, D.H. Malinowska, PhD, K.P. Tewari, PhD, Ryuji Ueno, MD, PhD, PhD) Poster 19516. Translational Physiology Wednesday April 30, 12:30 PM – 2:15 PM
– Unoprostone protects against cell death, reactive oxygen species, and apoptosis in a model retinitis pigmentosa system using expression of wild type and mutant rhodopsin (J. Chakrabarti, PhD, J. Cuppoletti, PhD, D.H. Malinowska, PhD, Ryuji Ueno, MD, PhD, PhD) Poster 19514. Cell and Molecular Physiology, Wednesday April 30th, 12:30 PM – 2:15 PM
Lubiprostone is a member of a class of compounds called prostones that directly activates ClC-2 chloride channels located in the apical membrane of the human intestinal epithelial cells. This activation causes an increase in chloride ions (Cl-) and intestinal fluid secretion into the lumen, thereby promoting the motility of the gastrointestinal (GI) tract contents.
Unoprostone isopropyl is a member of Sucampo’s family of prostones and is a synthetic docosanoid. It has received orphan drug designation for retinis pigmentosa in Europe by the EMA and in the United States by the FDA.
