RNS Number:2450L
Profile Therapeutics PLC
19 May 2003


LETTER TO:  PROFILE THERAPEUTICS PLC
            15th May 2003


NOTIFICATION UNDER PART VI OF THE COMPANIES ACT 1985 (AS AMENDED BY THE
COMPANIES ACT 1989)

I write to advise that Scottish Widows Investment Partnership Ltd, is interested
in 3,421,052 ordinary shares of the above mentioned company. Of this interest,
1,954,952 shares are material interests, which we understand represents 3.978%
of the relevant share capital, and constitutes a notifiable interest for the
purposes of Part VI of the Companies Act 1985. This is calculated on an issued
share capital of 49,143,423 shares.

This notification is made on behalf of Lloyds TSB Group plc, Lloyds TSB Bank plc
and Scottish Widows Group Limited who are deemed to be interested in these
shares as, like Scottish Widows Investment Partnership, they are all companies
within the Lloyds TSB Group of Companies.

The attached schedule identifies the registration details of this holding.

From:  S Brice (Manager Business Integrity Scottish Widows Investment
                Partnership)


As at 14 May 2003

Company                Stock          Total Fund       Group       Fund    Registered Holder                   Interest 
Name                   Description    Amount           Company           

PROFILE THERAPEUTICS   0RD 2P         441,614,000      SWIP        AAIAA   STATE STREET NOMINEES A/C XBY2      MATERIAL

                                      121,877,000      SWIP        ALEQI   STATE STREET NOMINEES A/C W32L      MATERIAL

                                      337,256,000      SWIP        APEQU   STATE STREET NOMINEES A/C W33H      MATERIAL

                                      373,382,000      SWIP        BH2AA   STATE STREET NOMINEES A/C XBJ2      MATERIAL

                                       75,100,000      SWIP        BL9AA   STATE STREET NOMINEES A/C XBK5      MATERIAL

                                      239,477,000      SWIP        GPS     STATE STREET NOMINEES A/C XBY4      MATERIAL

                                      140,628,000      SWIP        NOI     STATE STREET NOMINEES A/C W39N      MATERIAL

                                      225,618,000      SWIP        TSLTM   STATE STREET NOMINEES A/C XBK6      MATERIAL

                                    1,954,952,000

                      This information is provided by RNS
            The company news service from the London Stock Exchange

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