This Amendment No. 2 (this “Amendment”) amends and supplements the Tender Offer
Statement on Schedule TO (as amended and together with any subsequent amendments and supplements thereto, the “Schedule TO”) filed with the Securities and Exchange Commission on January 23, 2023 by Anemone Acquisition Corp., a
Delaware corporation and wholly owned subsidiary of Ipsen Biopharmaceuticals, Inc., a Delaware corporation and wholly owned subsidiary of Ipsen Pharma SAS, a French société par actions simplifiée and wholly owned
subsidiary of Ipsen S.A., a French société anonyme, to purchase all outstanding shares of common stock, $0.01 par value per share (“Shares”), of Albireo Pharma, Inc., a Delaware corporation,
at a price of $42.00 per Share, to the holder in cash, plus one non-transferable contractual contingent value right (“CVR”) per Share, which represents the right to receive a payment in cash
of $10.00 per CVR, contingent upon the achievement of a certain milestone, in each case, without interest and subject to any required withholding taxes, as described in the Offer to Purchase dated January 23, 2023 (together with any amendments
or supplements thereto, the “Offer to Purchase”) and in the accompanying Letter of Transmittal, which are annexed to and filed with the Schedule TO as Exhibits (a)(1)(A) and (a)(1)(B), respectively. All the information set forth in
the Offer to Purchase is incorporated herein by reference in response to all of the applicable items in the Schedule TO and is supplemented by the information specifically provided in the Schedule TO, except that such information is amended and
supplemented to the extent specifically provided in this Amendment. Unless otherwise indicated, references to sections in the Schedule TO are references to sections of the Offer to Purchase.
Except as otherwise set forth in this Amendment, the information set forth in the Schedule TO remains unchanged. This Amendment is being filed to reflect
certain updates as reflected below. Capitalized terms used but not defined herein have the meanings assigned to such terms in the Offer to Purchase or in the Schedule TO. You should read this Amendment together with the Schedule TO and the Offer to
Purchase.
ITEMS 1 THROUGH 9 AND ITEM 11.
Items 1 through 9 and Item 11 of the Schedule TO, to the extent such Items incorporate by reference the information contained in the Offer to Purchase, are
hereby amended and supplemented to include the following:
“The Offer and withdrawal rights expired as scheduled at 11:59 p.m.,
Eastern Time, on March 1, 2023. The Paying Agent has advised Purchaser that, as of the Expiration Time, 12,229,316 Shares (excluding Shares with respect to which Notices of Guaranteed Delivery were delivered) were validly tendered and not
validly withdrawn pursuant to the Offer, representing approximately 59% of the then outstanding Shares. As a result, the Minimum Condition has been satisfied. In addition, the Paying Agent has advised Purchaser that, as of the Expiration Time,
Notices of Guaranteed Delivery had been received for 5,618,538 Shares, representing approximately 27% of the then outstanding Shares.
Furthermore, as of March 1, 2023 at 11:59 p.m., Eastern Time, the required waiting period under the HSR Act with respect to the Offer and
the Merger expired. Accordingly, the Regulatory Condition has been fully satisfied.
As the Minimum Condition, the Regulatory Condition and
each of the other Offer Conditions have been satisfied, Purchaser has irrevocably accepted for payment all Shares that were validly tendered and not validly withdrawn pursuant to the Offer.
Ipsen and Purchaser expect to consummate the Merger on March 2, 2023 pursuant to the terms of the Merger Agreement in accordance with
Section 251(h) of the DGCL, without a vote on the adoption of the Merger Agreement by Albireo’s stockholders. As a result of the Merger, the separate corporate existence of Purchaser will cease and Albireo will continue as the surviving
corporation in the Merger under the name “Albireo Pharma, Inc.”, thereby becoming a wholly owned subsidiary of Ipsen.
At the
Effective Time, each Share issued and outstanding immediately prior to the Effective Time (other than Shares (a) held by Albireo (or in Albireo’s treasury) or any subsidiary of Albireo, or by Ipsen, Purchaser or any other direct or
indirect wholly owned subsidiary of Ipsen, or by Albireo stockholders who have properly exercised and perfected their statutory rights of appraisal under Delaware law, or (b) irrevocably accepted for purchase in the Offer) will be converted
into the right to receive the Merger Consideration, without interest and subject to any withholding of taxes required by applicable legal requirements. The Shares will be de-listed from, and will cease to
trade on, Nasdaq. Ipsen and Albireo intend to take steps to cause the termination of the registration of the Shares under the Exchange Act and suspend all of Albireo’s reporting obligations under the Exchange Act.”