Gilead Developing Ebola Drug
22 October 2015 - 4:40AM
Dow Jones News
Gilead Sciences Inc. confirmed Thursday it was developing an
experimental drug for Ebola after a London hospital revealed that
the treatment had been given to a nurse who had been readmitted
with the illness.
London's Royal Free Hospital said British nurse Pauline
Cafferkey, who contracted Ebola nine months ago in West Africa, was
readmitted on Oct. 9 with an "unusual late complication" of her
previous infection, according to the hospital website.
On Monday, doctors at the hospital upgraded her condition to
serious but stable after she deteriorated to critically ill last
week. A hospital consultant told the U.K. newspaper The Guardian
that she was being treated with the experimental drug known as
GS-5734.
Gilead didn't name Ms. Cafferkey in its statement but said its
compound was being provided to a female patient in the U.K. The
company said GS-5734 was requested by the hospital last week.
"It is very encouraging to hear that the patient in question is
doing better and is no longer in critical condition," said Norbert
Bischofberger, Gilead's chief scientific officer.
Ms. Cafferkey became the U.K.'s first confirmed Ebola patient
when she was diagnosed with the disease on Dec. 29, just hours
after returning home from Sierra Leone, where she had worked as a
volunteer to fight the virus that has killed thousands of people in
the region. She was treated at the Royal Free hospital for several
weeks and discharged in January.
The drug, now being tested on humans, had shown favorable
results in previous trials on animals, posting a 100% survival rate
in monkeys who initiated the treatment on the third day of
infection, according to Gilead.
Ebola is transmitted by direct contact with blood or body
fluids. The Centers for Disease Control and Prevention said the
2014 epidemic was the largest in history. There wasn't a single new
case of Ebola during the week ending Oct. 11 in West Africa, the
second consecutive week of such a stretch in 17 months, according
to the World Health Organization.
The outbreak began in Guinea, among Africa's poorest countries.
The nation has one of the world's worse ratios of doctors to
citizens, making it a fertile launchpad for a global Ebola epidemic
that has now claimed over 11,000 lives in more than six countries,
including the U.S.
Write to Ezequiel Minaya at ezequiel.minaya@wsj.com
Subscribe to WSJ: http://online.wsj.com?mod=djnwires
(END) Dow Jones Newswires
October 21, 2015 13:25 ET (17:25 GMT)
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