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| Holder | Type | Held (Actual) | % of Outstanding | Market Value | Date Reported |
|---|---|---|---|---|---|
| Mr. Alan Auerbach | Insider | 7,046,751 | 13.84% | US$ 49.40M | 2026-04-13 |
| Acorn Bioventures | Institution | 4,131,299 | 8.12% | US$ 28.96M | 2026-03-31 |
| BlackRock, Inc. | Institution | 3,598,952 | 7.07% | US$ 25.23M | 2026-03-31 |
| Acorn Bioventures 2, L.P. | Institution | 2,285,229 | 4.49% | US$ 16.02M | 2024-12-31 |
| Acadian Asset Management LLC | Institution | 2,041,759 | 4.01% | US$ 14.31M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 1,942,413 | 3.82% | US$ 13.62M | 2026-03-31 |
| American Century Investment Management Inc | Institution | 1,916,346 | 3.76% | US$ 13.43M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 1,817,681 | 3.57% | US$ 12.74M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 1,734,649 | 3.41% | US$ 12.16M | 2026-03-31 |
| Acorn Bioventures, L.P. | Institution | 1,654,823 | 3.25% | US$ 11.60M | 2024-12-31 |
| Millennium Management LLC | Institution | 1,477,519 | 2.90% | US$ 10.36M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 1,436,106 | 2.82% | US$ 10.07M | 2026-03-31 |
| LSV Asset Management | Institution | 1,182,868 | 2.32% | US$ 8.29M | 2026-03-31 |
| O'Shaughnessy Asset Management, LLC | Institution | 1,138,169 | 2.24% | US$ 7.98M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 1,017,342 | 2.00% | US$ 7.13M | 2026-03-31 |
| Bridgeway Capital Management, LLC | Institution | 979,382 | 1.92% | US$ 6.87M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 917,590 | 1.80% | US$ 6.43M | 2026-03-31 |
| Kennedy Capital Management LLC | Institution | 889,601 | 1.75% | US$ 6.24M | 2026-03-31 |
| AQR Capital Management, LLC | Institution | 785,391 | 1.54% | US$ 5.51M | 2026-03-31 |
| Connor, Clark & Lunn Investment Management Ltd. | Institution | 782,798 | 1.54% | US$ 5.49M | 2026-03-31 |
| Ritholtz Wealth Management | Institution | 774,308 | 1.52% | US$ 5.43M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 641,753 | 1.26% | US$ 4.50M | 2026-03-31 |
| Arrowstreet Capital, Limited Partnership | Institution | 538,155 | 1.06% | US$ 3.77M | 2026-03-31 |
| UBS Asset Management AG | Institution | 535,937 | 1.05% | US$ 3.76M | 2026-03-31 |
| SEI Investments Company | Institution | 508,182 | 1.00% | US$ 3.56M | 2026-03-31 |
| Goldman Sachs Asset Management, L.P. | Institution | 500,236 | 0.98% | US$ 3.51M | 2026-03-31 |
| D. E. Shaw & Co., L.P. | Institution | 351,235 | 0.69% | US$ 2.46M | 2026-03-31 |
| GlobeFlex Capital LP | Institution | 349,651 | 0.69% | US$ 2.45M | 2026-03-31 |
| BNY Asset Management | Institution | 347,881 | 0.68% | US$ 2.44M | 2026-03-31 |
| State Board of Administration of Florida | Institution | 272,890 | 0.54% | US$ 1.91M | 2026-03-31 |
| Morgan Stanley | Institution | 263,836 | 0.52% | US$ 1.85M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 251,683 | 0.49% | US$ 1.76M | 2026-03-31 |
| Russell Investment Management, LLC | Institution | 251,653 | 0.49% | US$ 1.76M | 2026-03-31 |
| Federated Hermes, Inc. | Institution | 237,715 | 0.47% | US$ 1.67M | 2026-03-31 |
| PGIM, Inc. | Institution | 223,039 | 0.44% | US$ 1.56M | 2026-03-31 |
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