RKV Rakovina Therapeutics Inc

Rakovina Therapeutics Inc. (TSXV:RKV), a biopharmaceutical company committed to advancing new cancer therapies based on novel DNA-damage response technologies, presented at the American Association of Cancer Research Annual Meeting.

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The AACR Annual Meeting, held from April 8th to 13th in New Orleans, is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. The Annual Meeting highlights the work of the best minds in cancer research from institutions worldwide.

Rakovina’s presentation, entitled “Evaluation of a Novel Class of Bifunctional DNA Alkylating PARP Inhibitors,” was delivered during the Combination Therapeutics session on April 11, 2022, highlighting pre-clinical research related to its novel kt-4000 series. The poster presentation will be available on the company’s website.

Rakovina Therapeutics was established in 2020 to develop new cancer treatments based on novel DNA-damage response technologies. DNA damage response mutations are the hallmarks of many cancers, which are one of the leading causes of death. Many cancers harbor a defect in natural DNA damage response mechanisms that allow tumor cells to evade the human immune system and grow unchecked into life-threatening malignancies.

kt-4000 represents a novel class of small molecule drug candidates that combine potent inhibition of polyADP-ribose polymerase (PARP) with DNA alkylating functionality in a single molecule. PARP is a key enzyme in the base-excision repair (BER) pathway, which is an important DNA-damage response mechanism involved in the repair of DNA single-strand breaks. Cells that are deficient in other repair mechanisms, such as homologous recombination (HR) repair, become highly dependent on BER for survival.

PARP inhibitors are important targeted cancer therapies that take advantage of HR-deficient cell’s dependence on BER. FDA-approved PARP inhibitors have become important in the treatment of HR-deficient tumors such as BRCA-mutant breast and ovarian cancers.

Dr. Mads Daugaard, president and chief scientific officer, stated: “The data presented at the AACR meeting demonstrate that kt-4000 series compounds provide, in a single molecule, potent DNA-damage, inhibition of repair and cell-cycle arrest similar to what was observed in prior laboratory studies employing two separate treatments. Furthermore, the anti-cancer mechanism observed appears to be distinct from FDA-approved PARP-inhibitors suggesting the potential for broad utility of drug candidates derived from this class.”

The company has established a pipeline of novel DNA-damage response inhibitors with the goal of advancing one or more drug candidates into human clinical trials and obtaining marketing approval for new cancer therapeutics from Health Canada, the United States Food and Drug Administration and similar international regulatory agencies.

The shares are currently trading at $0.18. For more information, please visit the company’s website www.RakovinaTherapeutics.com, contact David Hyman, CFO, at 403-613-1453 or by email at info@RakovinaTherapetics.com. For investor relations email IR@RakovinaTherapeutics.com.

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