Candel Therapeutics Inc (CADL) Options

You are most welcome.

Thanks for posting this interview. Great info. Thank you.

Thanks for posting this interview. Great info. Thank you.

Great insights, thanks.

On Feuerstein: He is an influencer - he needs content so he will say something about everything that is up or down.

On Tak, check out his history at Flagship on top of his time at GSK. Im sure if they put the right amount of $$ on the table he will "switch his mind".

Remember prostate is notoriously
immunologically cold but CAN 2409 still worked...
So I believe it wil be even more effective in NSCLC and panc.

No question PBM is a heavyweight in small biotech investing. And of course as you mention Paul Manning who leads them is on the board at Candel and just sank a bunch of money into buying shares personally it seems.

For those who are not that familiar with CADL, this short talk with CEO Tak is a good primer:



If I had to pick a couple of things that were the least positive in that talk, I would say these would be it:
1) Around 5:40 mark, Tak talking about some clinical trial results are coming in the next qtr and "if several of these are positive".... - tough enough to have one study meet endpoints, so hoping for several positive results adds just a bit more anxiety to this. But hopefully past data dictates hope might be justified.
2) Although Tak mentions the path forward will probably involved BP in the form of partnerships, he seems to leave the U.S. market for CADL alone and talks about turning the company into a small Pharma. Although he worked for GSK and recognizes how BP has a much greater ability to drive sales, his mentioning of keeping the US for himself sends up red flags for me about GIA. I have seen that happen to so many small bios. Egos eventually doom the path forward.

Will be watching this closely.

CADL under $9

I think the key here is that PBM Capital is involved. I’m sure you checked out their investing history, but it’s impressive. Further, it looks like Paul Manning is directly involved.

As for Feuerstein, even broken clocks are right twice a day.

I notice that an old nemesis (in another stock years ago) Adam Feuerstein seems to be mostly bashing CADL. Not sure what his deal is. He has attacked CADL in relation to a lung cancer trial since it was not placebo controlled. But not really sure what his problem is here with prostate cancer.

I will say that there seems to be one point that he may have and that I find confusing myself. If anyone can better explain this one top line bullet point in the press release I would appreciate it:

Operator
05/09/2024 at 06:17 PM
This is a common misconception that this strip is common area, but it is actually a part of your lot and needs to be maintained the same as your lawn. No worries though, we are only recently sending out letters/citations about landscape maintenance so you do not need to worry about being fined in the meantime. For reference, it takes close to two months for us to issue fines following the initial citation, so you have plenty of time to make arrangements to accommodate this.

"14.5% relative improvement in DFS observed at 54 months for the CAN-2409 treatment arm compared to the placebo control arm"

I am not sure exactly what they are saying. I know AF also questions why specifically the 54 months. TIA

9.42

great

Triple avg volume so far today with an hour left.  

NICE rebound this morning how long will it last

Big insider purchase 2 days ago:

https://www.secform4.com/filings/1841387/0000950170-24-137889.htm

why not the ATM

Not very TAK ful
couldve been done a lot better I believe
now driftwood until the next readout.... Will be another opportunity

CADL: Hopefully, they get a CURE for all that bad PROSTATE stuff!!! (Had 1/3rd mine removed at the VA Hospital in Palo Alto few years back; NO joking!! And yet STILL must get up circa 4-times every night to PISS --- not fun. And even Orion's 'Mr. Monk' posted, if I'm not mistaken, that he HAS Prostate Cancer itself.)

$7 + 4% 3.3 million offerings at 5.99 sunk it down 50%. Need cash for last part of trial prostate...another $18 million 

Not ideal, that's for sure, but development stage, they don't have much of a choice. Did you check out the CMO? He was with Chimerix when it soared and was a solid Company. Left well before they fell apart.

The execs at Candel are solid. Whether they can get it done, is another story, of course.

Can't see a dip below 6, but seems to make sense to average down. Good luck, if you're in it.

thats not how you build trust Peter!

yikes

$CADL Doubled shares overnight with offering now has 60 million shares increased from 30 million shares. Expect this dilution will take it to below $4 level it was at prior to run up this week. Remember: $CADL has no revenues, at risk that it will never have a product and is losing close to 40 million $ per year. FDA trials take years and this will be a zombie stock. Watch for $3 to 4$ price level due to dilution.

7.5s..

The stock isn’t going to zero

My problem is that I dont have a feeling for when that is most relevant.

Short positions do represent potential buying power

I always interpet them as to-be-buyers too.

It happens with these biomed stocks after a press release

And a lot of shares still sold short

Apparently professional asset managers did take a liking to this stock

CADL: No Sir!!! I simply WISH we had some legitimate "SCIENCE" somewhere on this Planet --- primarily in HEALTH CARE, MEDICINE, LIFE EXTENSION, GENOMICS, etc.

You are one of these anti-science people?

go go

CADL: If you SCORED some nice bucks behind this fluff news, well, CONGRATS to ya, Dude!!! That's ALL you can do with this "Health Science" crap!!! NEVER hold this MEDICAL junk long!!! Not even during ONE day of their bogus PR's. The simple fact that every hospital on this moronic Planet has a GERIATRICS DEPARTMENT is dispositive PROOF that this Planet has NO FUCKING KNOWLEDGE WHATSOEVER ABOUT ANY ASPECT OF HUMAN PHYSIOLOGY!!!!! Lastly, there's another Department in every hospital on this mindless Planet --- for which, however, said hospitals do not even display SIGNAGE --- but it is called, THE CEMETERY DEPARTMENT!!! And we ALL eventually go there!!! Even every one of the stupid DOCTORS, NURSES, & TECHNICIANS who are employed in those "Hospitals"!!! (Have ya finally learned the TRUTH about "Medical Science" today, fella??? And from a fellow iHuber!!!)

will be used in all cancers with nestin overexpression eventually

See who commented on the stock before today. I even commented last night. I think its fair to say i had conviction.
You guys are late to the party then tell me how bad their science is after the fact ... with the stock up 180% in the morning?
GL with that

--------------------------------

CADL: I know this stuff, you don't.

"Immunotherapy drugs like Candel's teach the immune system to find and destroy cancer cells. The drug helped 75.2% of patients with intermediate-to-high risk localized prostate cancer live for 54 months without any sign of cancer. In comparison, just 65.7% of the radiation-only group met the same bar."

If you think such PETTY differences in such 'studies' is significant, you are just plain IGNORANT!! I paltry 10% difference???!!!

Meet primary endpoint ph3 = fluff news
lol
What would be a PR of substance? Scientists turn lead into gold? Or breed the golden goose?

CADL: So much for such Phase-3 Medical BULLSHIT --- mere STATISTICAL ARTIFACTS --- so-called 'history-making' (baloney) "news" about Prostate Cancer!!! (The worst "Cancer" on this reprobate Planet is the MEDICAL IGNORANCE of the "Doctors" & "Researchers" THEMSELVES!!!!)

LOST roughly half the market cap from the session high
Will professional asset managers take a liking to it

https://www.biospace.com/press-releases/candel-therapeutics-announces-can-2409-achieved-primary-endpoint-in-phase-3-prostate-cancer-trial-showing-significantly-improved-disease-free-survival

CADL: One's BANK ACCT. might end of "PROSTRATE", if they invest in this FLUFF NEWS firm!! They have NOTHING at all to fix PROSTATE Cancer --- mere STATISTICAL ARTIFACTS resultant from their useless "clinical studies". (The only reason the PRICE of this stock might soar today is because Homo sapiens generally are frickin' IGNORANT of the truth behind the pathetic stupidity of so-called "Medical Science" on this Planet, Bro!! If Mankind KNEW anything at all about the Human genome or otherwise physiology, your beloved Son would be alive today!! I'm an Atheist, but I do hope your Son is now sitting at the right hand of JESUS, or something, Bro!!)

PS: Nevertheless, if you bought this one, CONGRATS if you score MONSTER TIME!!!

you mean Prostate 🙃

Prostrate phase 3 rules $12.34 + 166% 

They will make you feel like wood in the ocean then zoom it up in 1 go.
Easy to argue with people hard to argue with data/physics!

hehe there it is
sold 33% 10s .............. and some 12s

background https://www.fiercebiotech.com/biotech/ex-gsk-immunology-chief-takes-over-oncolytic-virus-biotech-candel-as-it-ramps-up-its

Cured GBM in patient....
Paul Peter Tak, the make-it-happen-man, parachuted in to bring this awesome platform to life. Watching closely... with the readouts in early 2025. Might run in anticipation soon.

Cured GBM in patient....
Paul Peter Tak, the make-it-happen-man, parachuted in to bring this awesome platform to life. Watching closely... with the readouts in early 2025. Might run in anticipation soon.