Protokinetix Inc (PK) (PKTX) Share Price

***PKTX..
Stem Cell Therapy Reverses Diabetes..***

According to a new study published in Science Advances, researchers have developed a novel cell transplantation technique that successfully reversed type 1 diabetes in mice, using human islets vascularized with adaptable endothelial cells for functional subcutaneous engraftment.

Breakthrough in Islet Transplantation
The innovative technique employs human reprogrammed vascular endothelial cells (R-VECs) to functionally vascularize pancreatic islets, addressing a major challenge in islet transplantation therapy1. This approach enables:

In vitro functional vascularization of islets with responsive glucose-stimulated insulin secretion

Successful reversal of hyperglycemia in diabetic mice through subcutaneous transplantation

High levels of human insulin in recipient serum, with hyperglycemia returning upon graft removal

R-VECs, engineered by transiently expressing the vascular-specific transcription factor ETV2, demonstrate remarkable adaptability by self-assembling into perfusable vascular networks and acquiring islet endothelial cell-specific characteristics when cocultured with human islets12. This breakthrough represents a significant step towards improved islet transplantation therapy, potentially offering a path to long-term insulin independence for type 1 diabetes patients34.

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Role of R-VECs in Vascularization
Microenvironmental determinants of endothelial cell ...
Reprogrammed vascular endothelial cells (R-VECs) play a crucial role in enhancing islet transplantation outcomes by providing robust vascularization. Their unique properties and adaptability make them particularly effective for supporting islet survival and function:

R-VECs form extensive vascular networks that arborize and penetrate islets, mimicking native pancreatic vasculature12

When co-cultured with islets, R-VECs acquire islet endothelial cell-specific characteristics, demonstrating remarkable adaptability34

R-VEC-formed blood vessels have larger diameters (13.5 ± 7.5 µm) compared to native human islet capillaries (6.8 ± 2.1 µm), potentially improving blood flow1

Cotransplanted R-VECs contribute substantially more to islet vascularization than host endothelial cells in subcutaneous transplants1

The vascular network formed by R-VECs successfully anastomoses with host circulation, ensuring long-term graft survival31

This advanced vascularization technique addresses a major challenge in islet transplantation, potentially improving graft survival and function while enabling transplantation in more accessible sites like the subcutaneous space.

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Subcutaneous Transplantation Success
Subcutaneous transplantation of vascularized islets marks a significant advancement in type 1 diabetes treatment. This site offers several advantages, including a large surface area, easy accessibility for transplantation and monitoring, and potential graft retrieval if necessary1. Previous attempts at subcutaneous islet transplantation had failed due to insufficient vascularization, but the use of R-VECs overcomes this challenge by forming blood vessels that arborize and vascularize the islets, effectively connecting with the host circulation23.

Transplanted R-VECs form functional blood vessels that support islet survival

Subcutaneous site allows for non-invasive monitoring and potential graft removal

Successful reversal of hyperglycemia in diabetic mice demonstrates the technique's efficacy12

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Implications for Type 1 Diabetes
This innovative approach addresses several key challenges in islet transplantation therapy, including the scarcity of donor organs and islet loss due to disconnection from extracellular matrix and vasculature during isolation1. By enabling effective vascularization, the technique potentially reduces inflammatory and rejection reactions that compromise islet survival1. Importantly, this method may pave the way for transplantation without the need for lifelong immunosuppression, a significant drawback of conventional approaches2. The success of this technique in animal models represents a promising step towards translating this therapy to human patients, offering hope for a more effective and durable treatment for type 1 diabetes34.

https://www.perplexity.ai/page/stem-cell-therapy-reverses-dia-clGsnmywR4ugK

This one may have potential....What is the OS?

Yeah but still very interesting to see a successful therapy using islet transplant to cure diabetes 1, which is making headlines.. And it's making headlines while it was conducted on mices, PKTX study is on human beings, much more impactful

they don't mention anything obvious specifically about AAGP or any companies. though. Could be all sorts of other research involved in islets transplantation.

Look at this guys, this is our time to shine !!!

***PKTX.. Dearest Ole Sun.. Have a Good Day and go back to sleep.. :+)

With volume like today’s so far, how could it fail?

it's got to reach .05 first : )

Company gonna get bought out ...... at $0.05 per share.

.0142 with nice bid support!

NEWS COMING!!!!!

your attitude seems to have changed

News coming!

Close at or above.015

surprised there isn't more insider buying if something is going on that's positive

see what happens next week.

News coming????
Watch for a jump in PPS

nice volume and a tiny increase in price

no movement in price, but nice volume

HyperPirate75, I see you are new to Investor's hub and to PhotoKinetix's board. Welcome to the IHub board. I look forward to your thoughts regarding PhotoKinetix's Islet transplant test.

Interesting opinion but i think you are wrong, this stock has been manipulated and accumulated for years, if they do end up posting positive data for a study about diabetes 1, the stock will go up. Islet transplant is a very new method to treat diabete 1 and Alberta uni is at the forefront of this new method, if PKTX enables safer and more efficient islet transplant, it will be a big deal

The share price will never move up. If it ever gets to five cents ..... those who bought millions and millions of shares at one cent or less will dump them all. Then the PPS will collapse again. The only true way for everyone to get something out of this stock is for there to be a negotiated total buyout. (only my opinion)

2021 was the last time this stock crossed through both the 50 and 200 day moving averages.

I am not selling. When people stop selling, it might move up

Big volume today....but as you see the PPS doesn't move....

***PKTX..If you call almost a million trades low.. :+O

Wow. Very little volume again today

***PKTX.. Whatever you say.. Ole Wise One.. :+)

I'm sorry for your loss.

shmp has just about set itself on fire. They had a fire years ago and are worth less now than after the ashes were swept up

***PKTX.. Dear "disgusted investor"...I hope your day is going well.. I have a question for you, why do you say "One thing about PKTX" on this MB, But say something totally opposite on another MB..(Natural Shrimp Inc.(SHMP).. About PKTX..???

***(Your Quote).."this stock is worse than my PKTX AAGP stock Protokinetix"..

***disgusted investor.. Don't worry about your comment on that MB(Natural Shrimp Inc.(SHMP)..At least we "Now" know what you are here on PKTX for..

***Have a great day, tell your buddy SPORT19 hello.. :+)

plenty of volume

to put around my tomato plants?

Why?

bought some more shares

I know I am not selling.

another nice day of volume 310000 2/5/25

2 more months not 3 mb

Lmao they changed the date of completion again, this time we get a precise date the 25th of march, let's see on the 25th if they put 3 more months to the clock

This thing is a dog....awful 

If there was anything going on the ask would be swallowed up....
This is how they set up the dump....

something must be up with the clinical results to have this trade 400,000 shares to start the day 1/28/25

got a link to what you are looking at?

There is a FAKE bid on the board....
This happens all the time at PKTX....
Big dump coming.....

this is on some sort of streak. Up five days. When is the last time that happened?

chart suggests there has been more volume at the beginning of this year than in prior years.

excellent volume 1/24/25 - 227000 as of 1 PM

plenty of volume again - 150000

I already tried, no answer, the only thing i can tell you, which is a fact not a supposition, is that the study is no longer recruiting. Which sounds obvious, but is still an information to take in this ocean of silence from the company

write them and ask. I wrote, but got no response.

Yes i know, that is why i'm posting this link from the study 1 year ago which shows positive data, so we can expect positive data for the results on the study that should come out right about now if they can update us on this goddamn study good grief, if nothing comes out of a 8 years study on islet transplants for diabetes 1, then roosters have teeths