FORM 3
        
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                       
1. Name and Address of Reporting Person * Yang Xiaodong 2. Date of Event Requiring Statement (MM/DD/YYYY)
7/29/2022 

 3. Issuer Name and Ticker or Trading Symbol Apexigen, Inc. [APGN]
(Last)        (First)        (Middle)
C/O AGEXIGEN, INC., 75 SHOREWAY ROAD, SUITE C		 4. Relationship of Reporting Person(s) to Issuer (Check all applicable)__X__ Director                          _____ 10% Owner
___X___ Officer (give title below)        _____ Other (specify below)
Chief Executive Officer /
(Street)
SAN CARLOS, CA 94070      
(City)              (State)              (Zip)
 5. If Amendment, Date Original Filed(MM/DD/YYYY)
 

 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock  497904  D   

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(MM/DD/YYYY)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Employee Stock Option (right to buy)   (1) 10/29/2023  Common Stock  219950  $1.27  D   
Employee Stock Option (right to buy)   (1) 6/25/2025  Common Stock  20489  $1.47  D   
Employee Stock Option (right to buy)   (1) 10/30/2025  Common Stock  461015  $1.66  D   
Employee Stock Option (right to buy)   (1) 12/16/2026  Common Stock  35856  $2.25  D   
Employee Stock Option (right to buy)   (1) 2/17/2027  Common Stock  30734  $2.25  D   
Employee Stock Option (right to buy)   (2) 5/22/2028  Common Stock  295978  $3.62  D   
Employee Stock Option (right to buy)   (3) 2/14/2029  Common Stock  99373  $6.54  D   
Employee Stock Option (right to buy)   (4) 2/20/2030  Common Stock  12296  $7.03  D   
Employee Stock Option (right to buy)   (5) 2/20/2030  Common Stock  79906  $4.59  D   
Employee Stock Option (right to buy)   (6) 2/12/2031  Common Stock  38417  $4.59  D   
Warrant (right to buy)   (7) 7/29/2027  Common Stock  10000  $11.50  D   

Explanation of Responses:
(1)  The shares subject to the option are fully vested and immediately exercisable.
(2)  The shares subject to the option vest in 48 equal monthly installments beginning on June 22, 2018.
(3)  The shares subject to the option vest in 48 equal monthly installments beginning on March 14, 2019.
(4)  The shares subject to the option vest in 48 equal monthly installments beginning on February 1, 2020.
(5)  The shares subject to the option vest in 48 equal monthly installments beginning on February 1, 2020.
(6)  The shares subject to the option vest in 48 equal monthly installments beginning on February 1, 2021.
(7)  The shares underlying the warrant become exercisable on August 28, 2022.

Remarks:
Exhibit 24 - Power of Attorney

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
Yang Xiaodong
C/O AGEXIGEN, INC.
75 SHOREWAY ROAD, SUITE C
SAN CARLOS, CA 94070		 X
Chief Executive Officer

Signatures
/s/ Francis Sarena, by power of attorney 8/8/2022
**Signature of Reporting Person Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.
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