(Amendment No. )1
Check the appropriate box
to designate the rule pursuant to which this Schedule is filed:
The information required
on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities
Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject
to all other provisions of the Act (however, see the Notes).
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1 |
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NAME OF REPORTING PERSON |
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Biotechnology Value Fund, L.P. |
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2 |
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CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
(a) ☒ |
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(b) ☐ |
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3 |
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SEC USE ONLY |
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4 |
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CITIZENSHIP OR PLACE OF ORGANIZATION |
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Delaware |
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NUMBER OF |
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5 |
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SOLE VOTING POWER |
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SHARES |
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BENEFICIALLY |
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0 shares |
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OWNED BY |
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6 |
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SHARED VOTING POWER |
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EACH |
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REPORTING |
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3,734,708 shares (1) |
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PERSON WITH |
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7 |
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SOLE DISPOSITIVE POWER |
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0 shares |
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8 |
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SHARED DISPOSITIVE POWER |
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3,734,708 shares (1) |
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9 |
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AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
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3,734,708 shares (1) |
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10 |
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CHECK BOX IF THE
AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES |
☐ |
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11 |
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PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
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4.0% (1) |
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12 |
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TYPE OF REPORTING PERSON |
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PN |
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(1) Represents Ordinary Shares of the Issuer (the “Shares”)
underlying 3,734,708 American Depositary Shares of the Issuer (the “ADSs”) directly owned by the Reporting Person. Each ADS
represents one Share.
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1 |
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NAME OF REPORTING PERSON |
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BVF I GP LLC |
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2 |
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CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
(a) ☒ |
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(b) ☐ |
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3 |
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SEC USE ONLY |
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4 |
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CITIZENSHIP OR PLACE OF ORGANIZATION |
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Delaware |
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NUMBER OF |
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5 |
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SOLE VOTING POWER |
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SHARES |
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BENEFICIALLY |
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0 shares |
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OWNED BY |
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6 |
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SHARED VOTING POWER |
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EACH |
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REPORTING |
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3,734,708 shares (1) |
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PERSON WITH |
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7 |
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SOLE DISPOSITIVE POWER |
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0 shares |
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8 |
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SHARED DISPOSITIVE POWER |
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3,734,708 shares (1) |
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9 |
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AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
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3,734,708 shares (1) |
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10 |
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CHECK BOX IF THE
AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES |
☐ |
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11 |
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PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
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4.0% (1) |
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12 |
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TYPE OF REPORTING PERSON |
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OO |
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(1) Represents Shares underlying 3,734,708 ADSs that may be deemed to
be beneficially owned by the Reporting Person (each ADS represents one Share).
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1 |
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NAME OF REPORTING PERSON |
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Biotechnology Value Fund II, L.P. |
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2 |
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CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
(a) ☒ |
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(b) ☐ |
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3 |
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SEC USE ONLY |
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4 |
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CITIZENSHIP OR PLACE OF ORGANIZATION |
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Delaware |
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NUMBER OF |
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5 |
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SOLE VOTING POWER |
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SHARES |
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BENEFICIALLY |
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0 shares |
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OWNED BY |
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6 |
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SHARED VOTING POWER |
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EACH |
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REPORTING |
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2,730,698 shares (1) |
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PERSON WITH |
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7 |
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SOLE DISPOSITIVE POWER |
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0 shares |
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8 |
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SHARED DISPOSITIVE POWER |
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2,730,698 shares (1) |
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9 |
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AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
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2,730,698 shares (1) |
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10 |
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CHECK BOX IF THE
AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES |
☐ |
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11 |
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PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
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2.9% (1) |
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12 |
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TYPE OF REPORTING PERSON |
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PN |
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(1) Represents Shares underlying 2,730,698 ADSs directly owned by the
Reporting Person (each ADS represents one Share).
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1 |
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NAME OF REPORTING PERSON |
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BVF II GP LLC |
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2 |
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CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
(a) ☒ |
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(b) ☐ |
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3 |
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SEC USE ONLY |
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4 |
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CITIZENSHIP OR PLACE OF ORGANIZATION |
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Delaware |
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NUMBER OF |
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5 |
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SOLE VOTING POWER |
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SHARES |
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BENEFICIALLY |
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0 shares |
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OWNED BY |
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6 |
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SHARED VOTING POWER |
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EACH |
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REPORTING |
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2,730,698 shares (1) |
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PERSON WITH |
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7 |
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SOLE DISPOSITIVE POWER |
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0 shares |
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8 |
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SHARED DISPOSITIVE POWER |
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2,730,698 shares (1) |
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9 |
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AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
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2,730,698 shares (1) |
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10 |
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CHECK BOX IF THE
AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES |
☐ |
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11 |
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PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
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2.9% (1) |
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12 |
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TYPE OF REPORTING PERSON |
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OO |
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(1) Represents Shares underlying 2,730,698 ADSs that may be deemed to
be beneficially owned by the Reporting Person (each ADS represents one Share).
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1 |
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NAME OF REPORTING PERSON |
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Biotechnology Value Trading Fund OS LP |
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2 |
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CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
(a) ☒ |
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(b) ☐ |
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3 |
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SEC USE ONLY |
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4 |
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CITIZENSHIP OR PLACE OF ORGANIZATION |
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Cayman Islands |
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NUMBER OF |
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5 |
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SOLE VOTING POWER |
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SHARES |
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BENEFICIALLY |
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0 shares |
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OWNED BY |
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6 |
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SHARED VOTING POWER |
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EACH |
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REPORTING |
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334,576 shares (1) |
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PERSON WITH |
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7 |
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SOLE DISPOSITIVE POWER |
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0 shares |
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8 |
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SHARED DISPOSITIVE POWER |
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334,576 shares (1) |
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9 |
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AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
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334,576 shares (1) |
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10 |
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CHECK BOX IF THE
AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES |
☐ |
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11 |
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PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
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Less than 1% (1) |
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12 |
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TYPE OF REPORTING PERSON |
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PN |
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(1) Represents Shares underlying 334,576 ADSs directly owned by the Reporting
Person (each ADS represents one Share).
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1 |
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NAME OF REPORTING PERSON |
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BVF Partners OS Ltd. |
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2 |
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CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
(a) ☒ |
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(b) ☐ |
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3 |
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SEC USE ONLY |
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4 |
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CITIZENSHIP OR PLACE OF ORGANIZATION |
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Cayman Islands |
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NUMBER OF |
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5 |
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SOLE VOTING POWER |
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SHARES |
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BENEFICIALLY |
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0 shares |
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OWNED BY |
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6 |
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SHARED VOTING POWER |
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EACH |
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REPORTING |
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334,576 shares (1) |
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PERSON WITH |
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7 |
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SOLE DISPOSITIVE POWER |
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0 shares |
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8 |
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SHARED DISPOSITIVE POWER |
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334,576 shares (1) |
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9 |
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AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
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334,576 shares (1) |
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10 |
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CHECK BOX IF THE
AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES |
☐ |
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11 |
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PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
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Less than 1% (1) |
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12 |
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TYPE OF REPORTING PERSON |
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CO |
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(1) Represents Shares underlying 334,576 ADSs that may be deemed to be
beneficially owned by the Reporting Person (each ADS represents one Share).
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1 |
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NAME OF REPORTING PERSON |
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BVF GP Holdings LLC |
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2 |
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CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
(a) ☒ |
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(b) ☐ |
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3 |
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SEC USE ONLY |
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4 |
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CITIZENSHIP OR PLACE OF ORGANIZATION |
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Delaware |
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NUMBER OF |
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5 |
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SOLE VOTING POWER |
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SHARES |
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BENEFICIALLY |
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0 shares |
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OWNED BY |
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6 |
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SHARED VOTING POWER |
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EACH |
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REPORTING |
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6,465,406 shares (1) |
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PERSON WITH |
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7 |
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SOLE DISPOSITIVE POWER |
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0 shares |
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8 |
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SHARED DISPOSITIVE POWER |
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6,465,406 shares (1) |
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9 |
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AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
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|
6,465,406 shares (1) |
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10 |
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CHECK BOX IF THE
AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES |
☐ |
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11 |
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PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
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6.9% (1) |
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12 |
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TYPE OF REPORTING PERSON |
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OO |
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(1) Represents Shares underlying 6,465,406 ADSs that may be deemed to
be beneficially owned by the Reporting Person (each ADS represents one Share).
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1 |
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NAME OF REPORTING PERSON |
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BVF Partners L.P. |
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2 |
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CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
(a) ☒ |
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(b) ☐ |
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3 |
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SEC USE ONLY |
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4 |
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CITIZENSHIP OR PLACE OF ORGANIZATION |
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Delaware |
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NUMBER OF |
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5 |
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SOLE VOTING POWER |
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SHARES |
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BENEFICIALLY |
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0 shares |
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OWNED BY |
|
6 |
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SHARED VOTING POWER |
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EACH |
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REPORTING |
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|
6,894,345 shares (1) |
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PERSON WITH |
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7 |
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SOLE DISPOSITIVE POWER |
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0 shares |
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8 |
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SHARED DISPOSITIVE POWER |
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6,894,345 shares (1) |
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9 |
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AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
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|
6,894,345 shares (1) |
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10 |
|
CHECK BOX IF THE
AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES |
☐ |
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11 |
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PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
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7.3% (1) |
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12 |
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TYPE OF REPORTING PERSON |
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PN, IA |
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(1) Represents Shares underlying 6,894,345 ADSs that may be deemed to
be beneficially owned by the Reporting Person (each ADS represents one Share).
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1 |
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NAME OF REPORTING PERSON |
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BVF Inc. |
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2 |
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CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
(a) ☒ |
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(b) ☐ |
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3 |
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SEC USE ONLY |
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4 |
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CITIZENSHIP OR PLACE OF ORGANIZATION |
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Delaware |
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NUMBER OF |
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5 |
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SOLE VOTING POWER |
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SHARES |
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|
|
|
BENEFICIALLY |
|
|
|
|
0 shares |
|
OWNED BY |
|
6 |
|
SHARED VOTING POWER |
|
EACH |
|
|
|
|
|
REPORTING |
|
|
|
|
6,894,345 shares (1) |
|
PERSON WITH |
|
7 |
|
SOLE DISPOSITIVE POWER |
|
|
|
|
|
|
|
|
|
|
|
|
0 shares |
|
|
|
8 |
|
SHARED DISPOSITIVE POWER |
|
|
|
|
|
|
|
|
|
|
|
|
6,894,345 shares (1) |
|
|
9 |
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
|
|
|
|
|
|
|
|
|
|
6,894,345 shares (1) |
|
|
10 |
|
CHECK BOX IF THE
AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES |
☐ |
|
|
|
|
|
|
|
|
|
|
|
|
11 |
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
|
|
|
|
|
|
|
|
|
|
7.3% (1) |
|
|
12 |
|
TYPE OF REPORTING PERSON |
|
|
|
|
|
|
|
|
|
|
CO |
|
(1) Represents Shares underlying 6,894,345 ADSs that may be deemed to be
beneficially owned by the Reporting Person (each ADS represents one Share).
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
1 |
|
NAME OF REPORTING PERSON |
|
|
|
|
|
|
|
|
|
|
Mark N. Lampert |
|
|
2 |
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
(a) ☒ |
|
|
|
|
(b) ☐ |
|
|
|
|
|
|
|
3 |
|
SEC USE ONLY |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
4 |
|
CITIZENSHIP OR PLACE OF ORGANIZATION |
|
|
|
|
|
|
|
|
|
|
United States |
|
NUMBER OF |
|
5 |
|
SOLE VOTING POWER |
|
SHARES |
|
|
|
|
|
BENEFICIALLY |
|
|
|
|
0 shares |
|
OWNED BY |
|
6 |
|
SHARED VOTING POWER |
|
EACH |
|
|
|
|
|
REPORTING |
|
|
|
|
6,894,345 shares (1) |
|
PERSON WITH |
|
7 |
|
SOLE DISPOSITIVE POWER |
|
|
|
|
|
|
|
|
|
|
|
|
0 shares |
|
|
|
8 |
|
SHARED DISPOSITIVE POWER |
|
|
|
|
|
|
|
|
|
|
|
|
6,894,345 shares (1) |
|
|
9 |
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
|
|
|
|
|
|
|
|
|
|
6,894,345 shares (1) |
|
|
10 |
|
CHECK BOX IF THE
AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES |
☐ |
|
|
|
|
|
|
|
|
|
|
|
|
11 |
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
|
|
|
|
|
|
|
|
|
|
7.3% (1) |
|
|
12 |
|
TYPE OF REPORTING PERSON |
|
|
|
|
|
|
|
|
|
|
IN |
|
(1) Represents Shares underlying 6,894,345 ADSs that may be deemed to
be beneficially owned by the Reporting Person (each ADS represents one Share).
| Item 1(a). | Name of Issuer: |
Centessa Pharmaceuticals plc, incorporated under the laws of England
and Wales (the “Issuer”).
| Item 1(b). | Address of Issuer’s Principal Executive Offices: |
1 Ashley Road, 3rd Floor
Altrincham, Cheshire WA14 2DT
United Kingdom
| Item 2(a). | Name of Person Filing |
| Item 2(b). | Address of Principal Business Office or, if None, Residence |
Biotechnology Value Fund, L.P. (“BVF”)
44 Montgomery St., 40th Floor
San Francisco, California 94104
Citizenship: Delaware
BVF I GP LLC (“BVF GP”)
44 Montgomery St., 40th Floor
San Francisco, California 94104
Citizenship: Delaware
Biotechnology Value Fund II, L.P. (“BVF2”)
44 Montgomery St., 40th Floor
San Francisco, California 94104
Citizenship: Delaware
BVF II GP LLC (“BVF2 GP”)
44 Montgomery St., 40th Floor
San Francisco, California 94104
Citizenship: Delaware
Biotechnology Value Trading Fund OS LP (“Trading
Fund OS”)
PO Box 309 Ugland House
Grand Cayman, KY1-1104
Cayman Islands
Citizenship: Cayman Islands
BVF Partners OS Ltd. (“Partners OS”)
PO Box 309 Ugland House
Grand Cayman, KY1-1104
Cayman Islands
Citizenship: Cayman Islands
BVF GP Holdings LLC (“BVF GPH”)
44 Montgomery St., 40th Floor
San Francisco, California 94104
Citizenship: Delaware
BVF Partners L.P. (“Partners”)
44 Montgomery St., 40th Floor
San Francisco, California 94104
Citizenship: Delaware
BVF Inc.
44 Montgomery St., 40th Floor
San Francisco, California 94104
Citizenship: Delaware
Mark N. Lampert (“Mr. Lampert”)
44 Montgomery St., 40th Floor
San Francisco, California 94104
Citizenship: United States
Each of the foregoing is referred to as a
“Reporting Person” and collectively as the “Reporting Persons.”
| Item 2(d). | Title of Class of Securities: |
Ordinary Shares, nominal value £0.002 per share (the “Shares”).
The Reporting Persons own American Depositary Shares of the Issuer (the “ADSs”), as set forth herein. Each ADS represents
one Share.
152309100
| Item 3. | If This Statement is Filed Pursuant to Rule 13d-1(b), or 13d-2(b) or (c), Check Whether the Person Filing
is a: |
|
|
/x/ |
Not applicable. |
|
|
|
|
|
(a) |
/ / |
Broker or dealer registered under Section 15 of the Exchange Act. |
|
|
|
|
|
(b) |
/ / |
Bank as defined in Section 3(a)(6) of the Exchange Act. |
|
|
|
|
|
(c) |
/ / |
Insurance company as defined in Section 3(a)(19) of the Exchange Act. |
|
|
|
|
|
(d) |
/ / |
Investment company registered under Section 8 of the Investment Company Act. |
|
|
|
|
|
(e) |
/ / |
An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E). |
|
|
|
|
|
(f) |
/ / |
An employee benefit plan or endowment fund in accordance with Rule 13d-1(b)(1)(ii)(F). |
|
|
|
|
|
(g) |
/ / |
A parent holding company or control person in accordance with Rule 13d-1(b)(1)(ii)(G). |
|
|
|
|
|
(h) |
/ / |
A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act. |
|
|
|
|
|
(i) |
/ / |
A church plan that is excluded from the definition of an investment company under Section 3(c)(14) of the Investment Company Act. |
|
|
|
|
|
(j) |
/ / |
Group, in accordance with Rule 13d-1(b)(1)(ii)(J). |
|
|
|
|
|
(k) |
/ / |
Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K). If filing as a non-U.S. institution in accordance with Rule 240.13d-1(b)(1)(ii)(J), please specify the type of institution: ____ |
| (a) | Amount beneficially owned: |
As of the close of business on June 16, 2022,
(i) BVF beneficially owns 3,734,708 Shares underlying ADSs it directly owns, (ii) BVF2 beneficially owns 2,730,698 Shares underlying ADSs
it directly owns, and (iii) Trading Fund OS beneficially owns 334,576 Shares underlying ADSs it directly owns.
BVF GP, as the general partner of BVF, may
be deemed to beneficially own the 3,734,708 Shares beneficially owned by BVF.
BVF2 GP, as the general partner of BVF2, may
be deemed to beneficially own the 2,730,698 Shares beneficially owned by BVF2.
Partners OS, as the general partner of Trading
Fund OS, may be deemed to beneficially own the 334,576 Shares beneficially owned by Trading Fund OS.
BVF GPH, as the sole member of each of BVF
GP and BVF2 GP, may be deemed to beneficially own the 6,465,406 Shares beneficially owned in the aggregate by BVF and BVF2.
Partners, as the investment manager of BVF,
BVF2 and Trading Fund OS, and the sole member of Partners OS, may be deemed to beneficially own the 6,894,345 Shares beneficially owned
in the aggregate by BVF, BVF2 and Trading Fund OS and 94,363 Shares underlying ADSs held in a certain Partners managed account (the “Partners
Managed Account”).
BVF Inc., as the general partner of Partners,
may be deemed to beneficially own the 6,894,345 Shares beneficially owned by Partners.
Mr. Lampert, as a director and officer of
BVF Inc., may be deemed to beneficially own the 6,894,345 Shares beneficially owned by BVF Inc.
The foregoing should not be construed in and
of itself as an admission by any Reporting Person as to beneficial ownership of any Shares owned by another Reporting Person. BVF GP disclaims
beneficial ownership of the Shares beneficially owned by BVF. BVF2 GP disclaims beneficial ownership of the Shares beneficially owned
by BVF2. Partners OS disclaims beneficial ownership of the Shares beneficially owned by Trading Fund OS. BVF GPH disclaims beneficial
ownership of the Shares beneficially owned by BVF and BVF2. Each of Partners, BVF Inc. and Mr. Lampert disclaims beneficial ownership
of the Shares beneficially owned by BVF, BVF2 and Trading Fund OS and the Shares underlying the ADSs held in the Partners Managed Account,
and the filing of this statement shall not be construed as an admission that any such person or entity is the beneficial owner of any
such securities.
The following percentages are based on 94,041,029
Shares outstanding as of May 9, 2022, as disclosed in the Issuer’s Definitive Proxy Statement on Schedule 14A filed with the Securities
and Exchange Commission on May 23, 2022.
As of the close of business on June 16, 2022,
(i) BVF beneficially owned approximately 4.0% of the outstanding Shares, (ii) BVF2 beneficially owned approximately 2.9% of the outstanding
Shares, (iii) Trading Fund OS beneficially owned less than 1% of the outstanding Shares, (iv) BVF GP may be deemed to beneficially own
approximately 4.0% of the outstanding Shares, (v) BVF2 GP may be deemed to beneficially own approximately 2.9% of the outstanding Shares,
(vi) Partners OS may be deemed to beneficially own less than 1% of the outstanding Shares, (vii) BVF GPH may be deemed to beneficially
own approximately 6.9% of the outstanding Shares and (viii) each of Partners, BVF Inc. and Mr. Lampert may be deemed to beneficially own
approximately 7.3% of the outstanding Shares (less than 1% of the outstanding Shares are represented by ADSs held in the Partners Managed
Account).
| (c) | Number of shares as to which such person has: |
| (i) | Sole power to vote or to direct the vote |
See Cover Pages Items 5-9.
| (ii) | Shared power to vote or to direct the vote |
See Cover Pages Items 5-9.
| (iii) | Sole power to dispose or to direct the disposition of |
See Cover Pages Items 5-9.
| (iv) | Shared power to dispose or to direct the disposition of |
See Cover Pages Items 5-9.
| Item 5. | Ownership of Five Percent or Less of a Class. |
Not Applicable.
| Item 6. | Ownership of More than Five Percent on Behalf of Another Person. |
BVF GPH, Partners, BVF Inc. and Mr. Lampert
share voting and dispositive power over the Shares beneficially owned by BVF and BVF2. Partners, BVF Inc. and Mr. Lampert share voting
and dispositive power over the Shares beneficially owned by Trading Fund OS and the Shares underlying the ADSs held in the Partners Managed
Account.
| Item 7. | Identification and Classification of the Subsidiary That Acquired the Security Being Reported on by the
Parent Holding Company or Control Person. |
Not Applicable.
| Item 8. | Identification and Classification of Members of the Group. |
See Exhibit 99.1.
| Item 9. | Notice of Dissolution of Group. |
Not Applicable.
By signing below each of the undersigned
certifies that, to the best of its knowledge and belief, the securities referred to above were not acquired and are not held for the purpose
of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in
connection with or as a participant in any transaction having that purpose or effect.
SIGNATURE
After reasonable inquiry and to
the best of his knowledge and belief, each of the undersigned certifies that the information set forth in this statement is true, complete
and correct.
Dated: June 16, 2022
BIOTECHNOLOGY VALUE FUND, L.P. |
|
BIOTECHNOLOGY VALUE TRADING FUND OS LP |
|
|
|
|
By: |
BVF I GP LLC., its general partner |
|
By: |
BVF Partners L.P., its investment manager |
|
|
|
By: |
BVF Inc., its general partner |
By: |
/s/ Mark N. Lampert |
|
|
|
|
Mark N. Lampert |
|
By: |
/s/ Mark N. Lampert |
|
Chief Executive Officer |
|
|
Mark N. Lampert |
|
|
|
|
President |
|
|
|
|
|
BVF I GP LLC |
|
|
|
|
|
|
BVF GP HOLDINGS LLC |
By: |
/s/ Mark N. Lampert |
|
|
|
Mark N. Lampert |
|
By: |
/s/ Mark N. Lampert |
|
Chief Executive Officer |
|
|
Mark N. Lampert |
|
|
|
|
Chief Executive Officer |
|
|
|
|
|
BIOTECHNOLOGY VALUE FUND II, L.P. |
|
|
|
|
|
BVF PARTNERS L.P. |
By: |
BVF II GP LLC, its general partner |
|
|
|
|
|
By: |
BVF Inc., its general partner |
By: |
/s/ Mark N. Lampert |
|
|
|
|
Mark N. Lampert |
|
By: |
/s/ Mark N. Lampert |
|
Chief Executive Officer |
|
|
Mark N. Lampert |
|
|
|
|
President |
|
|
|
|
|
BVF II GP LLC |
|
|
|
|
|
|
BVF INC. |
By: |
/s/ Mark N. Lampert |
|
|
|
Mark N. Lampert |
|
By: |
/s/ Mark N. Lampert |
|
Chief Executive Officer |
|
|
Mark N. Lampert |
|
|
|
|
President |
|
|
|
|
|
BVF PARTNERS OS LTD. |
|
|
|
|
|
|
/s/ Mark N. Lampert |
By: |
BVF Partners L.P., its sole member |
|
MARK N. LAMPERT |
By: |
BVF Inc., its general partner |
|
|
|
|
|
|
|
By: |
/s/ Mark N. Lampert |
|
|
|
Mark N. Lampert |
|
|
|
President |
|
|
|