UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, DC 20549

FORM N-Q

QUARTERLY SCHEDULE OF PORTFOLIO HOLDINGS OF REGISTERED MANAGEMENT INVESTMENT COMPANY
 
Investment Company Act file number 811-22123
 
Nuveen Municipal High Income Opportunity Fund 2
(Exact name of registrant as specified in charter)
 
Nuveen Investments
        333 West Wacker Drive, Chicago, Illinois 60606         
(Address of principal executive offices) (Zip code)
 

Kevin J. McCarthy
Vice President and Secretary
        333 West Wacker Drive, Chicago, Illinois 60606         
(Name and address of agent for service)
 
Registrant's telephone number, including area code:         312-917-7700        
 
Date of fiscal year end:             10/31          
 
Date of reporting period:          1/31/10         
 
Form N-Q is to be used by management investment companies, other than small business investment companies registered on Form N-5 (§§ 239.24 and 274.5 of this chapter), to file reports with the Commission, not later than 60 days after the close of the first and third fiscal quarters, pursuant to rule 30b1-5 under the Investment Company Act of 1940 (17 CFR 270.30b1-5). The Commission may use the information provided on Form N-Q in its regulatory, disclosure review, inspection, and policymaking roles.
 
A registrant is required to disclose the information specified by Form N-Q, and the Commission will make this information public. A registrant is not required to respond to the collection of information contained in Form N-Q unless the Form displays a currently valid Office of Management and Budget ("OMB") control number. Please direct comments concerning the accuracy of the information collection burden estimate and any suggestions for reducing the burden to the Secretary, Securities and Exchange Commission, 450 Fifth Street, NW, Washington, DC 20549-0609. The OMB has reviewed this collection of information under the clearance requirements of 44 U.S.C. § 3507.

 

Item 1. Schedule of Investments
 

  Portfolio of Investments (Unaudited)      
      Nuveen Municipal High Income Opportunity Fund 2 (NMD)      
      January 31, 2010      
Principal   Optional Call    
Amount (000) Description (1) Provisions (2) Ratings (3) Value
  Alabama – 1.6% (1.4% of Total Investments)      
$     2,290  Birmingham Special Care Facilities Financing Authority, Alabama, Revenue Bonds, Baptist Health  11/15 at 100.00  Baa2  $    2,098,464 
  System Inc., Series 2005A, 5.250%, 11/15/20       
1,000  Phenix City Industrial Development Board, Alabama, Environmental Improvement Revenue Bonds,  5/12 at 100.00  BBB  915,480 
  MeadWestvaco Corporation, Series 2002A, 6.350%, 5/15/35 (Alternative Minimum Tax)       
3,290  Total Alabama      3,013,944 
  Arizona – 4.8% (4.2% of Total Investments)      
1,000  Estrella Mountain Ranch Community Facilities District, Goodyear, Arizona, General Obligation  7/17 at 100.00  N/R  918,490 
  Bonds, Series 2007, 6.200%, 7/15/32       
2,575  Quechan Indian Tribe of the Fort Yuma Reservation, Arizona, Government Project Bonds, Series  12/17 at 102.00  N/R  2,097,544 
  2007, 7.000%, 12/01/27       
5,325  Salt Verde Financial Corporation, Arizona, Senior Gas Revenue Bonds, Series 2007,  No Opt. Call  4,557,188 
  5.000%, 12/01/37       
500  The Industrial Development Authority of the County of Pima Education Revenue Bonds, Arizona,  No Opt. Call  N/R  522,660 
  Legacy Traditional School Project, Series 2009, 8.500%, 7/01/39       
1,000  Yuma County Industrial Development Authority, Arizona, Exempt Revenue Bonds, Far West Water &  12/17 at 100.00  N/R  781,780 
  Sewer Inc. Refunding, Series 2007A, 6.375%, 12/01/37 (Alternative Minimum Tax)       
10,400  Total Arizona      8,877,662 
  Arkansas – 0.1% (0.1% of Total Investments)      
125  Little River County, Arkansas, Revenue Refunding Bonds, Georgia-Pacific Corporation, Series  4/10 at 100.00  B2  114,231 
  1998, 5.600%, 10/01/26 (Alternative Minimum Tax)       
  California – 13.8% (12.0% of Total Investments)      
1,470  Bay Area Toll Authority, California, Revenue Bonds, San Francisco Bay Area Toll Bridge, Series  4/18 at 100.00  AA  1,572,224 
  2009, Trust 2985-1, 17.596%, 4/01/34 (IF)       
2,000  California Educational Facilities Authority, Revenue Bonds, Dominican University, Series 2006,  12/16 at 100.00  Baa3  1,665,220 
  5.000%, 12/01/36       
1,020  California Housing Finance Agency, California, Home Mortgage Revenue Bonds, Series 2008B,  8/17 at 100.00  AA–  927,435 
  5.000%, 2/01/28 (Alternative Minimum Tax)       
1,000  California Municipal Finance Authority, Revenue Bonds, Harbor Regional Center Project, Series  11/19 at 100.00  Ba1  1,012,380 
  2009, 8.500%, 11/01/39       
1,825  California Statewide Community Development Authority, Revenue Bonds, Daughters of Charity  7/15 at 100.00  BBB  1,585,651 
  Health System, Series 2005A, 5.250%, 7/01/35       
2,000  California Statewide Community Development Authority, Revenue Bonds, St. Joseph Health System,  7/18 at 100.00  AA–  2,051,260 
  Series 2007C, 5.750%, 7/01/47 – FGIC Insured       
1,350  California Statewide Community Development Authority, Revenue Bonds, Sutter Health, Tender  5/18 at 100.00  A+  1,129,815 
  Option Bond Trust 3048, 13.549%, 11/15/48 (IF)       
3,150  California Statewide Community Development Authority, Revenue Bonds, Sutter Health, Tender  11/16 at 100.00  N/R  2,636,235 
  Option Bond Trust 3102, 15.732%, 11/15/46 (IF)       
  Daly City Housing Development Finance Agency, California, Mobile Home Park Revenue Bonds,       
  Franciscan Mobile Home Park Refunding, Series 2007A:       
2,000  5.000%, 12/15/37  12/17 at 100.00  A–  1,651,340 
1,975  6.500%, 12/15/47  12/17 at 100.00  N/R  1,647,407 
1,370  Elk Grove Community Facilities District 2005-1, California, Special Tax Bonds, Series 2007,  9/15 at 102.00  N/R  906,063 
  5.250%, 9/01/37       
  Golden State Tobacco Securitization Corporation, California, Enhanced Tobacco Settlement       
  Asset-Backed Bonds, Series 2007A-1:       
4,000  5.750%, 6/01/47  6/17 at 100.00  BBB  3,054,600 
2,500  5.125%, 6/01/47  6/17 at 100.00  BBB  1,726,825 
1,000  Lathrop Financing Authority, California, Revenue Bonds, Water Supply Project Series 2003,  6/13 at 100.00  N/R  889,570 
  6.000%, 6/01/35       
500  Los Angeles Regional Airports Improvement Corporation, California, Sublease Revenue Bonds, Los  12/12 at 102.00  B–  494,250 
  Angeles International Airport, American Airlines Inc. Terminal 4 Project, Series 2002C,       
  7.500%, 12/01/24 (Alternative Minimum Tax)       
2,500  San Bernardino Community College District, California, General Obligation Bonds, Tender Option  8/16 at 100.00  AAA  2,711,400 
  Bond Trust 11780-1, 17.561%, 8/01/31 – AGM Insured (IF)       
29,660  Total California      25,661,675 
  Colorado – 6.8% (5.9% of Total Investments)      
1,500  Arista Metropolitan District, Colorado, Special Revenue Bonds, Series 2008, 9.250%, 12/01/37  12/15 at 100.00  N/R  1,351,050 
1,520  Colorado Educational and Cultural Facilities Authority, Charter School Revenue Bonds, Windsor  5/17 at 100.00  BB+  1,212,869 
  Academy, Series 2007A, 5.700%, 5/01/37       
2,000  Colorado Educational and Cultural Facilities Authority, Revenue Bonds, Pikes Peak School of  6/18 at 102.00  N/R  1,759,940 
  Expeditionary Learning Charter School, Series 2008, 6.625%, 6/01/38       
1,480  Colorado Health Facilities Authority, Colorado, Revenue Bonds, Catholic Health Initiatives,  9/16 at 100.00  AA  1,465,999 
  Series 2006A, 5.000%, 9/01/41       
5,045  Colorado Housing and Finance Authority, Revenue Bonds, Confluence Energy LLC Project, Series  4/17 at 100.00  N/R  3,230,818 
  2007, 6.750%, 4/01/27 (Alternative Minimum Tax)       
1,000  Confluence Metropolitan District, Colorado, General Obligation Limited Tax Bonds, Series 2007,  12/17 at 100.00  N/R  725,760 
  5.400%, 12/01/27       
1,000  Plaza Metropolitan District 1, Lakewood, Colorado, Tax Increment Revenue Bonds, Series 2003,  6/14 at 101.00  N/R  990,990 
  8.000%, 12/01/25       
1,700  Public Authority for Colorado Energy, Natural Gas Revenue Bonds, Colorado Springs Utilities,  No Opt. Call  1,850,280 
  Series 2008, 6.500%, 11/15/38       
15,245  Total Colorado      12,587,706 
  Connecticut – 0.5% (0.5% of Total Investments)      
1,000  Harbor Point Infrastructure Improvement District, Connecticut, Special Obligation Revenue  4/20 at 100.00  N/R  1,004,540 
  Bonds, Harbor Point Project, Series 2010A, 7.875%, 4/01/39 (WI/DD, Settling 2/04/10)       
  Florida – 14.7% (12.8% of Total Investments)      
1,000  Ave Maria Stewardship Community Development District, Florida, Capital Improvement Revenue  5/16 at 100.00  N/R  726,400 
  Bonds, Series 2006A, 5.125%, 5/01/38       
1,000  Beeline Community Development District, Palm Beach County, Florida, Special Assessment Bonds,  5/18 at 100.00  N/R  1,002,950 
  Series 2008A, 7.000%, 5/01/37       
1,000  Colonial Country Club Community Development District, Florida, Capital Improvement Revenue  5/13 at 101.00  A+  1,027,530 
  Bonds, Series 2003, 6.400%, 5/01/33       
2,000  Escambia County, Florida, Environmental Improvement Revenue Bonds, International Paper Company  8/11 at 100.00  BBB  1,754,200 
  Projects, Series 2006B, 5.000%, 8/01/26 (Alternative Minimum Tax)       
1,320  Fishhawk Community Development District II, Florida, Special Assessment Revenue Bonds, Series  5/14 at 100.00  N/R  1,185,928 
  2004A, 6.125%, 5/01/34       
2,000  Habitat Community Development District, Florida, Capital Improvement Revenue Bonds, Series  No Opt. Call  N/R  1,691,640 
  2004, 5.850%, 5/01/35       
1,000  Martin County Industrial Development Authority, Florida, Industrial Development Revenue Bonds,  6/10 at 100.00  BB+  1,000,290 
  Indiantown Cogeneration LP, Series 1994A, 7.875%, 12/15/25 (Alternative Minimum Tax)       
2,915  Old Palm Community Development District, Florida, Special Assessment Bonds, Palm Beach  5/15 at 101.00  N/R  2,461,659 
  Gardens, Series 2004A, 5.900%, 5/01/35       
1,500  Palm Glades Community Development District, Florida, Special Assessment Bond, Series 2008A,  5/18 at 100.00  N/R  1,100,835 
  7.125%, 5/01/39       
1,180  Pine Island Community Development District, Florida, Special Assessment Bonds, Bella Collina,  5/12 at 101.00  N/R  772,286 
  Series 2004, 5.750%, 5/01/35       
995  Poinciana West Community Development District, Florida, Special Assessment Bonds, Series 2007,  5/17 at 100.00  N/R  822,616 
  6.000%, 5/01/37       
970  Reunion West Community Development District, Florida, Special Assessment Bonds, Series 2004,  5/12 at 101.00  N/R  401,512 
  6.250%, 5/01/36       
3,800  South Miami Health Facilities Authority, Florida, Revenue Bonds, Baptist Health Systems of  8/17 at 100.00  AA–  3,484,562 
  South Florida, Trust 1030, 13.382%, 8/15/37 (IF)       
6,000  Split Pine Community Development District, Florida, Special Assessment Bonds, Series 2007A,  5/17 at 100.00  N/R  3,752,220 
  5.250%, 5/01/39       
2,345  Stoneybrook Venice Community Development District, Florida, Capital Improvement Revenue Bonds,  5/18 at 100.00  N/R  2,278,238 
  Series 2007, 6.750%, 5/01/38       
3,450  Tolomato Community Development District, Florida, Special Assessment Bonds, Series 2006,  5/14 at 101.00  N/R  2,353,625 
  5.400%, 5/01/37       
2,000  Westchester Community Development District 1, Florida, Special Assessment Bonds, Series 2003,  5/13 at 101.00  N/R  1,434,500 
  6.125%, 5/01/35       
34,475  Total Florida      27,250,991 
  Georgia – 2.7% (2.3% of Total Investments)      
1,000  Atlanta, Georgia, Tax Allocation Bonds, Beltline Project Series 2008A, Series 2008B, Series  1/19 at 100.00  N/R  1,004,420 
  2008C, Series 2009B, Series 2009C, 7.500%, 1/01/31       
1,170  Clayton County Development Authority, Georgia, Special Facilities Revenue Bonds, Delta Air  6/15 at 100.00  CCC+  1,177,781 
  Lines, Inc. Project, Series 2009B, 9.000%, 6/01/35 (Alternative Minimum Tax)       
1,250  Clayton County Development Authority, Georgia, Special Facilities Revenue Bonds, Delta Air  6/20 at 100.00  CCC+  1,290,313 
  Lines, Inc. Project, Series 2009, 8.750%, 6/01/29       
845  Effingham County Development Authority, Georgia, Solid Waste Disposal Revenue Bonds, Ft. James  7/10 at 100.00  BB–  826,638 
  Project, Series 1998, 5.625%, 7/01/18 (Alternative Minimum Tax) (4)       
1,000  Fulton County Residential Care Facilities Authority, Georgia, Revenue Bonds, Elderly Care,  7/17 at 100.00  N/R  662,500 
  Lenbrook Square Project, Series 2006A, 5.125%, 7/01/42       
5,265  Total Georgia      4,961,652 
  Illinois – 10.2% (8.9% of Total Investments)      
1,100  Hillside, Cook County, Illinois, Senior Lien Tax Increment Revenue Bonds, Mannheim  1/18 at 102.00  N/R  967,725 
  Redevelopment Project, Series 2008, 7.000%, 1/01/28       
5,620  Illinois Finance Authority, Charter School Revenue Bonds, Chicago Charter School Foundation,  No Opt. Call  BBB  4,841,180 
  Series 2007, 5.000%, 12/01/36       
1,900  Illinois Finance Authority, Revenue Bonds, Provena Health, Series 2009A, 7.750%, 8/15/34  8/19 at 100.00  BBB+  2,140,350 
1,500  Illinois Finance Authority, Revenue Bonds, Roosevelt University, Series 2007, 5.500%, 4/01/37  4/17 at 100.00  Baa2  1,399,935 
2,000  Illinois Finance Authority, Revenue Bonds, Silver Cross Hospital and Medical Centers, Series  8/19 at 100.00  BBB  2,071,320 
  2009, 6.875%, 8/15/38       
500  Illinois FInance Authority, Revenue Bonds, Southern Illinois Healthcare Enterprises, Inc.,  3/20 at 100.00  AAA  493,885 
  Series 2005, 5.250%, 3/01/30 (WI/DD, Settling 2/18/10) – AGM Insured       
2,000  Lombard Public Facilities Corporation, Illinois, First Tier Conference Center and Hotel  1/16 at 100.00  B+  1,286,020 
  Revenue Bonds, Series 2005A-2, 5.500%, 1/01/36 – ACA Insured       
  Southwestern Illinois Development Authority, Illinois, Saint Clair County Comprehensive Mental       
  Health Center, Series 2007:       
1,295  6.200%, 6/01/17  No Opt. Call  N/R  1,257,795 
3,020  6.625%, 6/01/37  6/17 at 103.00  N/R  2,741,163 
1,000  Southwestern Illinois Development Authority, Local Government Program Revenue Bonds, Granite  3/14 at 100.00  N/R  988,740 
  City Project, Series 2009B, 7.750%, 3/01/22       
750  Springfield, Sangamon County, Illinois, Special Service Area (Legacy Pointe) Ad Valorem Tax  3/17 at 102.00  N/R  760,583 
  Bonds, Series 2009, 7.875%, 3/01/32       
20,685  Total Illinois      18,948,696 
  Indiana – 3.1% (2.7% of Total Investments)      
3,000  Hospital Authority of Delaware County, Indiana, Hospital Revenue Bonds, Cardinal Health  8/16 at 100.00  Baa3  2,622,570 
  System, Series 2006, 5.125%, 8/01/29       
1,600  Indiana Bond Bank, Special Program Gas Revenue Bonds, JP Morgan Ventures Energy Corporation  No Opt. Call  Aa3  1,661,680 
  Guaranteed, Series 2007A, 15.229%, 10/15/20 (IF)       
  Vigo County, Indiana, Hospital Authority, Union Hospital, Revenue Bonds, Series 2007:       
250  5.700%, 9/01/37  9/17 at 100.00  N/R  208,140 
1,625  5.800%, 9/01/47  9/17 at 100.00  N/R  1,334,580 
6,475  Total Indiana      5,826,970 
  Iowa – 0.3% (0.2% of Total Investments)      
500  Iowa Student Loan Liquidity Corporation, Student Loan Revenue Bonds, Refunding Series 2009-2,  12/19 at 100.00  A1  509,085 
  5.500%, 12/01/25       
  Louisiana – 4.2% (3.6% of Total Investments)      
3,500  Louisiana Local Government Environmental Facilities & Community Development Authority, Revenue  11/17 at 100.00  BB  3,622,325 
  Bonds, Westlake Chemical Corporation Project, Series 2007, 6.750%, 11/01/32       
4,000  Louisiana Local Government Environmental Facilities and Community Development Authority,  12/17 at 100.00  N/R  3,182,920 
  Revenue Bonds, Southgate Suites Hotel LLC Project, Series 2007A, 6.750%, 12/15/37       
1,000  Tobacco Settlement Financing Corporation, Louisiana, Tobacco Settlement Asset-Backed Bonds,  5/11 at 101.00  BBB  942,120 
  Series 2001B, 5.875%, 5/15/39       
8,500  Total Louisiana      7,747,365 
  Maryland – 0.4% (0.3% of Total Investments)      
1,000  Maryland Economic Development Corporation, Revenue Bonds, Chesapeake Bay Hyatt Conference  12/16 at 100.00  N/R  719,970 
  Center, Series 2006A, 5.000%, 12/01/31       
  Massachusetts – 0.0% (0.0% of Total Investments)      
90  Boston Industrial Development Financing Authority, Massachusetts, Senior Revenue Bonds,  9/12 at 102.00  Caa3  51,692 
  Crosstown Center Project, Series 2002, 6.500%, 9/01/35 (Alternative Minimum Tax)       
  Michigan – 0.9% (0.8% of Total Investments)      
1,750  Michigan Public Educational Facilities Authority, Charter School Revenue Bonds, American  12/17 at 100.00  N/R  1,419,233 
  Montessori Academy, Series 2007, 6.500%, 12/01/37       
20  Michigan State Hospital Finance Authority, Hospital Revenue Bonds, Detroit Medical Center  2/10 at 100.00  Ba3  16,922 
  Obligated Group, Series 1998A, 5.250%, 8/15/23       
325  Michigan State Hospital Finance Authority, Hospital Revenue Refunding Bonds, Detroit Medical  4/10 at 100.00  BB–  246,236 
  Center Obligated Group, Series 1997A, 5.250%, 8/15/27 – AMBAC Insured       
2,095  Total Michigan      1,682,391 
  Minnesota – 1.5% (1.3% of Total Investments)      
3,000  St. Paul Housing and Redevelopment Authority, Minnesota, Revenue Bonds, Healtheast Inc.,  11/15 at 100.00  BB+  2,764,110 
  Series 2005, 6.000%, 11/15/35       
  Missouri – 2.7% (2.4% of Total Investments)      
1,000  Hanley Road Corridor Transportation Development District, Brentwood and Maplewood, Missouri,  10/19 at 100.00  A–  1,017,240 
  Transportation Sales Revenue Bonds, Series 2009, 5.875%, 10/01/36       
1,000  Missouri Development Finance Board. Infrastructure Facilities Revenue Bonds, City of  4/14 at 100.00  A+  1,021,930 
  Independence, Missouri – Events Center Project, Series 2009F, 6.250%, 4/01/38       
500  Saint Louis Industrial Development Authority, Missouri, Empowerment Zone Hotel Facilities  12/19 at 107.00  N/R  491,415 
  Revenue Bonds, Laurel Embassy Suites, Series 2009, 8.500%, 12/15/39       
40  Saint Louis Industrial Development Authority, Missouri, Saint Louis Convention Center  12/10 at 102.00  Ca  13,831 
  Headquarters Hotel Project, Series 2000A, 7.000%, 12/15/15 (Alternative Minimum Tax) (5)       
1,000  Saint Louis, Missouri, Orpheum Theater Community Improvement District, Property and Sales Tax  No Opt. Call  N/R  1,002,160 
  Revenue Bonds, Series 2009, 9.000%, 3/01/29       
1,953  Saint Louis, Missouri, Tax Increment Financing Revenue Bonds, Fashion Square Redevelopment  9/10 at 100.00  N/R  1,462,621 
  Project, Series 2008A, 6.300%, 8/22/26       
5,493  Total Missouri      5,009,197 
  Montana – 0.3% (0.3% of Total Investments)      
710  Montana Board of Investments, Resource Recovery Revenue Bonds, Yellowstone Energy LP, Series  No Opt. Call  N/R  596,045 
  1993, 7.000%, 12/31/19 (Alternative Minimum Tax)       
  Nevada – 1.3% (1.1% of Total Investments)      
55  Clark County, Nevada, Industrial Development Revenue Bonds, Nevada Power Company, Series  4/10 at 100.00  BB+  50,817 
  1995A, 5.600%, 10/01/30 (Alternative Minimum Tax)       
1,200  Director of Nevada State Department of Business and Industry, Revenue Bonds, Las Vegas  7/10 at 100.00  Caa2  500,004 
  Monorail Project, First Tier, Series 2000, 5.375%, 1/01/40 – AMBAC Insured       
  Sparks Tourism Improvement District 1, Legends at Sparks Marina, Nevada, Senior Sales Tax       
  Revenue Bonds Series 2008A:       
1,000  6.500%, 6/15/20  6/18 at 100.00  Ba3  963,450 
1,000  6.750%, 6/15/28  6/18 at 100.00  Ba3  918,290 
3,255  Total Nevada      2,432,561 
  New Jersey – 4.1% (3.6% of Total Investments)      
700  Bayonne Redevelopment Agency, New Jersey, Revenue Bonds, Royal Caribbean Cruises Project,  11/16 at 100.00  BB–  526,001 
  Series 2006A, 5.375%, 11/01/35 (Alternative Minimum Tax)       
  New Jersey Economic Development Authority, Special Facilities Revenue Bonds, Continental       
  Airlines Inc., Series 1999:       
2,000  6.250%, 9/15/19 (Alternative Minimum Tax)  9/11 at 100.00  1,880,020 
55  6.400%, 9/15/23 (Alternative Minimum Tax)  3/10 at 101.00  50,411 
240  6.250%, 9/15/29 (Alternative Minimum Tax)  3/10 at 101.00  210,962 
25  New Jersey Economic Development Authority, Special Facilities Revenue Bonds, Continental  11/10 at 101.00  23,994 
  Airlines Inc., Series 2000, 7.000%, 11/15/30 (Alternative Minimum Tax)       
3,200  New Jersey Health Care Facilities Financing Authority, New Jersey, Revenue Bonds, Saint Peters  7/18 at 100.00  Baa2  3,134,976 
  University Hospital, Series 2007, 5.750%, 7/01/37       
1,000  New Jersey Health Care Facilities Financing Authority, Revenue Bonds, Saint Joseph’s  No Opt. Call  BBB–  1,033,970 
  Healthcare System Obligated Group Issue, Series 2008, 6.000%, 7/01/18       
700  New Jersey Turnpike Authority, Revenue Bonds, Series 2009E, 5.250%, 1/01/40  1/19 at 100.00  A+  726,733 
7,920  Total New Jersey      7,587,067 
  New Mexico – 0.2% (0.2% of Total Investments)      
500  Montecito Estates Public Improvement District, New Mexico, Special Levee Revenue Bonds, Series  10/17 at 100.00  N/R  429,380 
  2007, 7.000%, 10/01/37       
  New York – 1.0% (0.9% of Total Investments)      
1,000  New York City Industrial Development Agency, New York, American Airlines-JFK International  8/18 at 100.00  B–  981,500 
  Airport Special Facility Revenue Bonds, Series 2005, 7.625%, 8/01/25 (Mandatory put 8/01/16)       
  (Alternative Minimum Tax)       
1,030  New York City Industrial Development Agency, New York, Civic Facility Revenue Bonds, Special  7/16 at 101.00  N/R  899,128 
  Needs Facilities Pooled Program, Series 2008A-1, 5.800%, 7/01/23       
2,030  Total New York      1,880,628 
  North Carolina – 3.0% (2.6% of Total Investments)      
1,970  Albemarle Hospital Authority, North Carolina, Health Care Facilities Revenue Bonds, Series  10/17 at 100.00  N/R  1,500,687 
  2007, 5.250%, 10/01/38       
1,260  Charlotte-Mecklenberg Hospital Authority, North Carolina, Carolinas HealthCare System Revenue  1/18 at 100.00  AA–  1,250,323 
  Bonds, Series 2008, Trust 1149-3, 13.566%, 1/15/47 (IF)       
  North Carolina Capital Facilities Financing Agency, Educational Facilities Revenue Bond,       
  Meredith College, Series 2008A:       
1,740  6.000%, 6/01/31  6/18 at 100.00  BBB  1,760,306 
1,000  6.125%, 6/01/35  6/18 at 100.00  BBB  1,006,060 
5,970  Total North Carolina      5,517,376 
  Ohio – 4.0% (3.5% of Total Investments)      
4,845  Buckeye Tobacco Settlement Financing Authority, Ohio, Tobacco Settlement Asset-Backed Revenue  6/17 at 100.00  BBB  3,717,375 
  Bonds, Senior Lien, Series 2007A-2, 5.875%, 6/01/47       
1,250  Ohio State, Hospital Facility Revenue Refunding Bonds, Cleveland Clinic Health System  1/19 at 100.00  Aa2  1,446,225 
  Obligated Group, Tender Option Bond Trust 3551, 19.787%, 1/01/39 (IF)       
1,015  Ohio, Environmental Facilities Revenue Bonds, Ford Motor Company, Series 2000, 6.150%, 6/01/30  6/10 at 101.00  Caa1  814,507 
  (Alternative Minimum Tax)       
2,000  Western Reserve Port Authority, Ohio, Solid Waste Facility Revenue Bonds, Central Waste Inc.,  7/17 at 102.00  N/R  1,528,360 
  Series 2007A, 6.350%, 7/01/27 (Alternative Minimum Tax)       
9,110  Total Ohio      7,506,467 
  Oklahoma – 0.4% (0.3% of Total Investments)      
165  Oklahoma Development Finance Authority, Revenue Bonds, Saint John Health System, Series 2007,  2/17 at 100.00  150,785 
  5.000%, 2/15/42       
45  Tulsa Municipal Airport Trust, Oklahoma, Revenue Bonds, American Airlines Inc., Series 1995,  6/10 at 100.00  B–  38,312 
  6.250%, 6/01/20       
500  Tulsa Municipal Airport Trust, Oklahoma, Revenue Refunding Bonds, American Airlines Inc.,  No Opt. Call  Caa2  490,920 
  Series 2004A, 7.750%, 6/01/35 (Mandatory put 12/01/14)       
710  Total Oklahoma      680,017 
  Oregon – 0.1% (0.1% of Total Investments)      
25  Oregon, Economic Development Revenue Bonds, Georgia Pacific Corp., Series 1995CLVII, 6.350%,  4/10 at 100.00  BB–  24,757 
  8/01/25 (Alternative Minimum Tax) (4)       
125  Oregon, Economic Development Revenue Refunding Bonds, Georgia Pacific Corp., Series 1997-183,  4/10 at 100.00  B2  115,771 
  5.700%, 12/01/25       
150  Total Oregon      140,528 
  Pennsylvania – 2.0% (1.7% of Total Investments)      
500  Allegheny Country Industrial Development Authority, Allegheny County, Pennsylvania,  No Opt. Call  BB  520,030 
  Environmental Improvement Revenue Bonds, United States Steel Corporation Project, Refunding       
  Series 2009, 6.750%, 11/01/24       
1,010  Chester County Industrial Development Authority, Pennsylvania, Avon Grove Charter School  12/17 at 100.00  BB+  901,991 
  Revenue Bonds, Series 2007A, 6.375%, 12/15/37       
450  Lancaster County Hospital Authority, Pennsylvania, Revenue Bonds, Brethren Village Project,  7/17 at 100.00  N/R  425,016 
  Series 2008A, 6.500%, 7/01/40       
1,000  Pennsylvania Economic Development Finance Authority, Solid Waste Disposal Revenue Bonds (USG  6/10 at 101.00  B+  822,410 
  Corporation Project) Series 1999, 6.000%, 6/01/31 (Alternative Minimum Tax)       
1,000  Pennsylvania Housing Finance Agency, Single Family Mortgage Revenue Bonds, Tender Option Bond  4/19 at 100.00  AA+  951,440 
  Trust 4657, 16.307%, 10/01/29 (IF) (6)       
3,960  Total Pennsylvania      3,620,887 
  Puerto Rico – 0.0% (0.0% of Total Investments)      
20  Puerto Rico Ports Authority, Special Facilities Revenue Bonds, American Airlines Inc., Series  6/10 at 100.00  CCC+  14,883 
  1996A, 6.250%, 6/01/26 (Alternative Minimum Tax)       
  Rhode Island – 0.3% (0.2% of Total Investments)      
500  Rhode Island Tobacco Settlement Financing Corporation, Tobacco Settlement Asset-Backed Bonds,  6/12 at 100.00  BBB  476,040 
  Series 2002A, 6.250%, 6/01/42       
  South Carolina – 2.4% (2.1% of Total Investments)      
1,100  Georgetown County, South Carolina, Environmental Improvement Revenue Bonds, International  8/11 at 100.00  BBB  931,040 
  Paper Company, Series 2006A, 5.000%, 8/01/30 (Alternative Minimum Tax)       
3,477  Lancaster County, South Carolina, Special Assessment Bonds, Edgewater II Improvement District,  No Opt. Call  N/R  3,452,418 
  Series 2007B, 7.700%, 11/01/17       
4,577  Total South Carolina      4,383,458 
  Tennessee – 3.2% (2.8% of Total Investments)      
2,000  Sullivan County Health Educational and Housing Facilities Board, Tennessee, Revenue Bonds,  3/13 at 100.00  N/R  1,825,540 
  Wellmont Health System, Refunding Series 200A, 5.486%, 9/01/32       
  Sumner County Health, Educational, and Housing Facilities Board, Tennessee, Revenue Refunding       
  Bonds, Sumner Regional Health System Inc., Series 2007:       
1,500  5.500%, 11/01/37  11/17 at 100.00  N/R  870,000 
1,000  5.500%, 11/01/46  11/17 at 100.00  N/R  580,000 
2,761  The Tennessee Energy Acquisition Corporation, Gas Revenue Bonds, Series 2006B, 5.625%, 9/01/26  No Opt. Call  N/R  2,634,049 
7,261  Total Tennessee      5,909,589 
  Texas – 11.0% (9.6% of Total Investments)      
1,000  Alliance Airport Authority, Texas, Special Facilities Revenue Bonds, American Airlines Inc.,  12/12 at 100.00  CCC+  625,960 
  Series 2007, 5.250%, 12/01/29 (Alternative Minimum Tax)       
440  Brazos River Authority, Texas, Pollution Control Revenue Refunding Bonds, TXU Electric  No Opt. Call  CCC  414,080 
  Company, Series 2001C, 5.750%, 5/01/36 (Mandatory put 11/01/11) (Alternative Minimum Tax)       
2,100  Clifton Higher Education Finance Corporation, Texas, Education Revenue Bonds, Tejano Center  No Opt. Call  BBB–  2,417,856 
  for Community Concerns, Inc.-Raul Yzaguirre School for Success, Refunding Series 2009A,       
  8.750%, 2/15/28       
3,000  Danbury Higher Education Authority Inc., Texas, Golden Rule Charter School Revenue Bonds,  2/18 at 100.00  BB+  2,671,140 
  Series 2008A, 6.500%, 8/15/38       
990  Hidalgo Willacy Housing Finance Corporation, Texas, Multifamily Housing Revenue Bonds,  1/14 at 102.00  N/R  933,986 
  Heritage Square Apartments Project, Series 2003A, 7.000%, 1/01/39       
1,330  La Vernia Higher Education Financing Corporation, Texas, Education Revenue Bonds, Amigos Por  2/16 at 100.00  N/R  1,113,104 
  Vida Friends For Life Public Charter School, Series 2008, 6.375%, 2/15/37       
335  North Texas Thruway Authority, Second Tier System Revenue Refunding Bonds, Series 2008,  1/18 at 100.00  A3  339,660 
  5.750%, 1/01/38       
110  Sabine River Authority, Texas, Pollution Control Revenue Bonds, TXU Energy Company LLC  No Opt. Call  CCC  103,520 
  Project, Series 2001B, 5.750%, 5/01/30 (Mandatory put 11/01/11) (Alternative Minimum Tax)       
385  Sabine River Authority, Texas, Pollution Control Revenue Refunding Bonds, TXU Electric  No Opt. Call  CCC  362,316 
  Company, Series 2001A, 5.500%, 5/01/22 (Mandatory put 11/01/11)       
2,000  Sabine River Authority, Texas, Pollution Control Revenue Refunding Bonds, TXU Energy Company  8/13 at 101.00  CCC  1,259,980 
  LLC Project, Series 2003B, 6.150%, 8/01/22       
4,255  Tarrant County Cultural and Educational Facilities Finance Corporation, Texas, Revenue Bonds,  2/17 at 100.00  AA–  4,139,604 
  Texas Health Resources Project, Trust 1031, 12.136%, 2/15/36 (IF)       
500  Texas Municipal Gas Acquisition and Supply Corporation I, Gas Supply Revenue Bonds, Senior  No Opt. Call  535,885 
  Lien Series 2008D, 6.250%, 12/15/26       
985  Texas Public Finance Authority, Charter School Revenue Bonds, School of Excellence Charter  12/14 at 100.00  BB  929,742 
  School, Series 2004A, 7.000%, 12/01/34       
5,000  Texas Turnpike Authority, First Tier Revenue Bonds, Central Texas Turnpike System, Series  8/12 at 100.00  BBB+  4,597,650 
  2002A, 5.000%, 8/15/42 – AMBAC Insured       
22,430  Total Texas      20,444,483 
  Utah – 3.5% (3.0% of Total Investments)      
  Utah State Charter School Finance Authority, Noah Webster Academy Revenue Bonds, Series:       
500  6.250%, 6/15/28  6/17 at 100.00  N/R  443,140 
1,430  6.500%, 6/15/38  6/17 at 100.00  N/R  1,237,479 
5,550  Utah State Charter School Finance Authority, Revenue Bonds, Summit Academy Project, Series  12/17 at 100.00  BBB–  4,824,560 
  2007A, 5.800%, 6/15/38       
7,480  Total Utah      6,505,179 
  Virgin Islands – 0.5% (0.5% of Total Investments)      
1,000  Virgin Islands Public Finance Authority, Revenue Bonds, Refinery Project – Hovensa LLC, Series  1/14 at 100.00  Baa3  1,008,310 
  2003, 6.125%, 7/01/22 (Alternative Minimum Tax)       
  Virginia – 0.6% (0.5% of Total Investments)      
50  Goochland County Industrial Development Authority, Virginia, Industrial Development Revenue  6/10 at 100.50  B2  46,063 
  Refunding Bonds, Nekoosa Packaging Corporation Project, Series 1998, 5.650%, 12/01/25       
  (Alternative Minimum Tax) (4)       
1,000  Virginia Small Business Financing Authority Revenue Bonds (Hampton Roads Proton Beam Therapy  7/14 at 102.00  N/R  1,039,720 
  Institute at Hampton University, LLC Project), Series 2009, 9.000%, 7/01/39       
1,050  Total Virginia      1,085,783 
  Washington – 6.2% (5.5% of Total Investments)      
2,415  FYI Properties, Washington, Lease Revenue Bonds, Washington State Department of Information  6/19 at 100.00  AA  3,030,680 
  Services Project, Tender Option Bond Trust 2009-14A&B, 19.590%, 6/01/34 (IF)       
3,500  Kalispel Indian Tribe, Washington, Priority Distribution Bonds, Series 2008, 6.750%, 1/01/38  No Opt. Call  N/R  2,911,930 
7,000  Washington State Health Care Facilities Authority, Revenue Bonds, Northwest Hospital and  No Opt. Call  N/R  5,690,440 
  Medical Center of Seattle, Series 2007, 5.700%, 12/01/32       
12,915  Total Washington      11,633,050 
  West Virginia – 0.3% (0.3% of Total Investments)      
740  Ohio County Commission, West Virginia, Special District Excise Tax Revenue Bonds, Fort Henry  3/16 at 100.00  N/R  589,817 
  Economic Development, Series 2006B, 5.625%, 3/01/36       
  Wisconsin – 1.0% (0.9% of Total Investments)      
30  Green Bay Redevelopment Authority, Wisconsin, Industrial Development Revenue Bonds, Fort James  No Opt. Call  N/R  28,240 
  Project, Series 1999, 5.600%, 5/01/19 (Alternative Minimum Tax)       
360  Nekoosa, Wisconsin, Pollution Control Revenue Bonds, Nekoosa Paper Inc. Project, Series 1999B,  No Opt. Call  B2  355,016 
  5.500%, 7/01/15       
1,000  Wisconsin Health and Educational Facilities Authority, Revenue Bonds, Ministry Healthcare  2/12 at 101.00  A+  780,459 
  Inc., Tender option Bond Trust 3114, 15.825%, 2/15/32 – NPFG Insured (IF)       
1,500  Wisconsin Health and Educational Facilities Authority, Revenue Bonds, Wheaton Franciscan  8/16 at 100.00  BBB+  745,139 
  Healthcare System, Series 2006, Trust 2187, 14.574%, 8/15/34 (IF)       
2,890  Total Wisconsin      1,908,854 
  Wyoming – 1.0% (0.9% of Total Investments)      
2,000  Sweetwater County, Wyoming, Solid Waste Disposal Revenue Bonds, FMC Corporation, Series 2005,  12/15 at 100.00  BBB+  1,852,020 
  5.600%, 12/01/35 (Alternative Minimum Tax)       
$ 244,476  Total Investments (cost $224,468,461) – 114.7%      212,934,299 
  Borrowings – (18.9)% (7)      (35,000,000) 
  Other Assets Less Liabilities – 4.2%      7,734,604 
  Net Assets Applicable to Common Shares – 100%      $ 185,668,903 


 
 
 
 
 
 

Investments in Derivatives
 
Forward Swaps outstanding at January 31, 2010:
 
    Fund     Fixed Rate     Unrealized
  Notional Pay/Receive Floating Rate Fixed Rate Payment Effective Termination Appreciation
Counterparty Amount Floating Rate Index (Annualized) Frequency Date (8) Date (Depreciation)
JPMorgan  $6,000,000  Receive  3-Month USD-LIBOR  3.413%  Semi-Annually  4/09/10  4/09/39  $1,034,400 
Royal Bank of Canada  3,000,000  Receive  3-Month USD-LIBOR  3.327  Semi-Annually  4/23/10  4/23/39  563,700 
                $1,598,100 

Futures Contracts at January 31, 2010:
 
          Unrealized
  Contract Number of Contract   Appreciation
Type Position Contracts Expiration Value (Depreciation)
U.S. Treasury 30-Year Bond  Short  (87)  3/10  $(10,336,688)  $166,302 

Fair Value Measurements
 
In determining the value of the Fund’s investments, various inputs are used. These inputs are summarized in the three broad levels listed below:
 
  Level 1 – Quoted prices in active markets for identical securities.
 
  Level 2 – Other significant observable inputs (including quoted prices for similar securities, interest rates, prepayment speeds, credit risk, etc.).
 
  Level 3 – Significant unobservable inputs (including management’s assumptions in determining the fair value of investments).
 
The inputs or methodology used for valuing securities are not an indication of the risk associated with investing in those securities. The following is a summary of the Fund’s fair value measurements as of January 31, 2010:
 
  Level 1 Level 2 Level 3 Total
Investments:         
Municipal Bonds  $          —  $212,934,299  $ —  $212,934,299 
Derivatives:         
Forward Swaps*  —  1,598,100  —  1,598,100 
Future Contracts*  166,302  —  —  166,302 
Total  $166,302  $214,532,399  $ —  $214,698,701 
* Represents net unrealized appreciation (depreciation).         

Derivative Instruments and Hedging Activities
 
The Fund records derivative instruments at fair value, with changes in fair value recognized on the Statement of Operations, when applicable. Even though the Fund's investments in derivatives may represent economic hedges, they are considered to be non-hedge transactions for financial reporting purposes.
 
The following table presents the fair value of all derivative instruments held by the Fund as of January 31, 2010, the location of these instruments on the Statement of Assets and Liabilities, and the primary underlying risk exposure.
 
    Location on the Statement of Assets and Liabilities
Underlying Derivative Asset Derivatives Liability Derivatives
Risk Exposure Instrument Location Value Location   Value
Interest Rate  Forward Swaps  Unrealized appreciation on  $1,598,100  —    $ — 
    forward swaps*         
Interest Rate  Futures  Deposits with brokers for open  166,302  —    — 
    futures contracts and Receivable for         
    variation margin on futures contracts**         
Total      $1,764,402      $ — 

Represents cumulative appreciation (depreciation) of swap contracts as reported on the Portfolio 
  of Investments. 
**  Value represents cumulative unrealized appreciation (depreciation) of futures contracts as 
  reported in the Portfolio of Investments and not the deposits with brokers, if any, or the 
  receivable or payable for variation margin on futures contracts presented on the Statement of Assets 
  and Liabilities. 
Income Tax Information
 
The following information is presented on an income tax basis. Differences between amounts for financial statement and federal income tax purposes are primarily due to timing differences in recognizing taxable market discount, timing differences in recognizing certain gains and losses on investment transactions and the treatment of investments in inverse floating rate securities reflected as financing transactions, if any. To the extent that differences arise that are permanent in nature, such amounts are reclassified within the capital accounts on the Statement of Assets and Liabilities presented in the annual report, based on their federal tax basis treatment; temporary differences do not require reclassification. Temporary and permanent differences do not impact the net asset value of the Fund.
 
At January 31, 2010, the cost of investments was $228,517,276.
 
Gross unrealized appreciation and gross unrealized depreciation of investments at January 31, 2010, were as follows:
 
Gross unrealized:   
  Appreciation  $    8,851,324 
  Depreciation  (24,434,301)
Net unrealized appreciation (depreciation) of investments  $(15,582,977)

(1)  All percentages shown in the Portfolio of Investments are based on net assets applicable to Common 
  shares unless otherwise noted. 
(2)  Optional Call Provisions: Dates (month and year) and prices of the earliest optional call or redemption. 
  There may be other call provisions at varying prices at later dates. Certain mortgage-backed securities 
  may be subject to periodic principal paydowns. 
(3)  Ratings: Using the higher of Standard & Poor’s Group (“Standard & Poor’s”) or Moody’s Investor Service, 
  Inc. (“Moody’s”) rating. Ratings below BBB by Standard & Poor’s or Baa by Moody’s are considered to be 
  below investment grade. 
(4)  The issuer has received a formal adverse determination from the Internal Revenue Service (the “IRS”) 
  regarding the tax-exempt status of the bonds’ coupon payments. The Fund will continue to treat coupon 
  payments as tax-exempt income until such time that it is formally determined that the interest on the 
  bonds should be treated as taxable. 
(5)  The Fund’s Adviser has concluded this issue is not likely to meet its future interest payment obligations 
  and has directed the Fund’s custodian to cease accruing additional income on the Fund’s records. 
(6)  Investment, or portion of investment, has been pledged to collateralize the net payment obligations for 
  investments in derivatives. 
(7)  Borrowings as a percentage of Total Investments is 16.4%. 
(8)  Effective date represents the date on which both the Fund and counterparty commence interest payment 
  accruals on each forward swap contract. 
N/R  Not rated. 
WI/DD  Purchased on a when-issued or delayed delivery basis. 
(IF)  Inverse floating rate investment. 
USD-LIBOR  United States Dollar-London Inter-Bank Offered Rate. 


 

Item 2. Controls and Procedures.

a.  
The registrant's principal executive and principal financial officers, or persons performing similar functions, have concluded that the registrant's disclosure controls and procedures (as defined in Rule 30a-3(c) under the Investment Company Act of 1940, as amended (the "1940 Act") (17 CFR 270.30a-3(c))) are effective, as of a date within 90 days of the filing date of this report that includes the disclosure required by this paragraph, based on their evaluation of the controls and procedures required by Rule 30a-3(b) under the 1940 Act (17 CFR 270.30a-3(b)) and Rule 13a-15(b) or 15d-15(b) under the Securities Exchange Act of 1934 (17 CFR 240.13a-15(b) or 240.15d-15(b)).
 
 
b.  
There were no changes in the registrant's internal control over financial reporting (as defined in Rule 30a-3(d) under the 1940 Act (17 CFR 270.30a-3(d)) that occurred during the registrant's last fiscal quarter that have materially affected, or are reasonably likely to materially affect, the registrant's internal control over financial reporting.
 
Item 3. Exhibits.

File as exhibits as part of this Form a separate certification for each principal executive officer and principal financial officer of the registrant as required by Rule 30a-2(a) under the 1940 Act (17 CFR 270.30a-2(a)), exactly as set forth below: See EX-99 CERT attached hereto.

 

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.
 
(Registrant)   Nuveen Municipal High Income Opportunity Fund 2 
 
By (Signature and Title)     /s/ Kevin J. McCarthy                    
                                                   Kevin J. McCarthy
                                                   Vice President and Secretary
 
Date          April 1, 2010        
 
Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated.
 
By (Signature and Title)     /s/ Gifford R. Zimmerman                    
                                                    Gifford R. Zimmerman
                                                  Chief Administrative Officer (principal executive officer) 
 
Date          April 1, 2010        
 
By (Signature and Title)     /s/ Stephen D. Foy                              
                                                   Stephen D. Foy
                                                  Vice President and Controller (principal financial officer) 
 
Date         April 1, 2010        

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