TIDMSNG
RNS Number : 8967R
Synairgen plc
27 September 2017
Press release
Synairgen plc
('Synairgen' or the 'Company')
Interim results for the six months ended 30 June 2017
Southampton, UK - 27 September 2017: Synairgen plc (LSE: SNG),
the respiratory drug discovery and development company, today
announces its unaudited interim results for the six months ended 30
June 2017.
Highlights (including post period-end)
Operational
-- AZD9412 (SNG001) INEXAS clinical trial update, announcing AstraZeneca's decision to return the rights of inhaled
interferon beta (IFN-beta) to Synairgen for strategic reasons, despite positive effects on markers of antiviral
activity and lung function
-- Exploratory analysis of INEXAS data in patients with a confirmed viral infection revealed significant findings in
both lung function and asthma control (see separate press release issued today)
-- Strategy for SNG001 to move into the substantial Chronic Obstructive Pulmonary Disease (COPD) market and a Phase
II trial is planned (see separate press release issued today)
-- Good progress made with Lysyl oxidase-like 2 enzyme (LOXL2) inhibitor programme in collaboration with Pharmaxis
following additional positive data generated from two preclinical models of idiopathic pulmonary fibrosis (IPF)
-- Following successful completion of preclinical pharmacology and toxicology studies, PXS-5382A, a compound from
the anti-fibrotic LOXL2 inhibitor programme, is now being prepared to commence Phase I clinical development
Financial
-- Research and development expenditure of GBP1.09 million (30 June 2016: GBP1.15 million) as the Company advanced
the ongoing LOXL2 collaboration with Pharmaxis through pre-clinical studies
-- The loss from operations for the six months ended 30 June 2017 was GBP1.58 million (30 June 2016: GBP1.69 million
loss)
-- Cash and bank deposits of GBP3.08 million (30 June 2016: GBP6.31 million)
Richard Marsden, CEO of Synairgen, commented: "We are extremely
excited by the positive findings from the INEXAS Phase II trial in
asthma which support our progression of SNG001 into Phase II
clinical studies in COPD. In addition, our collaboration with
Pharmaxis has made great progress and we are looking forward to
entering the clinic with PXS-5382A."
-Ends-
For further information, please contact:
Synairgen plc Tel: +44 (0) 23 8051 2800
Richard Marsden, Chief Executive Officer
John Ward, Finance Director
FinnCap (NOMAD) Tel: +44 (0) 20 7220 0500
Geoff Nash, James Thompson (Corporate Finance)
Stephen Norcross, Simon Johnson (Corporate Broking)
Consilium Strategic Communications (Financial Media and Investor
Relations)
Mary-Jane Elliott / Sue Stuart / Laura Thornton
synairgen@consilium-comms.com Tel: +44 (0) 20 3709 5701
Notes for Editors
About Synairgen
Synairgen is a respiratory drug discovery and development
company founded by University of Southampton Professors Stephen
Holgate, Donna Davies and Ratko Djukanovic. The business, focused
primarily on asthma and COPD, uses its differentiating human
biology BioBank platform and world-renowned international academic
KOL network to discover and develop novel therapies for respiratory
disease. Leveraging its scientific and clinical facilities at
Southampton General Hospital, the Company uses in vitro and ex vivo
models to progress opportunities into clinical development. The
BioBank of human samples is used in these models to increase
confidence in the likelihood of successful drug development. Core
to Synairgen's business strategy is the realisation of value via
licensing transactions. In August 2015 the Company entered into a
collaboration with Pharmaxis to develop an oral LOXL2 inhibitor to
reduce fibrosis in patients with idiopathic pulmonary fibrosis
(IPF). Synairgen is quoted on AIM (LSE: SNG). For more information
about Synairgen, please see www.synairgen.com
Chairman's and Chief Executive Officer's Review
OPERATING REVIEW
Summary
In the first six months of the year we made excellent progress
with our anti-fibrotic Lysyl Oxidase-Like 2 enzyme (LOXL2)
inhibitor programme in collaboration with our partner Pharmaxis. In
March, we reported additional positive preclinical data from the
programme supporting the potential of inhibitors in the fatal lung
disease idiopathic pulmonary fibrosis (IPF). Post period-end, we
reported that a compound had been selected for entry into a Phase I
trial in Q4 2017.
In April, AstraZeneca returned the rights to SNG001 (inhaled
IFN-beta) to Synairgen for strategic reasons. The asthma
exacerbation rate was lower than expected in the INEXAS trial and
therefore the effects of the drug on exacerbations could not be
determined. However, initial data from the trial suggested improved
lung function recovery with inhaled IFN-beta and elevated markers
of antiviral defence.
Since then, we have analysed the INEXAS data including only the
patients who had a confirmed respiratory virus infection, and
gratifyingly we found very similar results to our own original
Phase II trial of IFN-beta. The low exacerbation rate in asthma
makes development of an antiviral drug solely in asthma challenging
from an economic perspective. We are currently planning to move
SNG001 into COPD, where we believe it is reasonable to expect that
the positive clinical effects observed in asthma will translate
across to COPD, a disease where there is a greater opportunity to
reduce exacerbation occurrence and associated healthcare costs. See
separate press release issued today.
LOXL2 inhibitor programme
Our collaboration with Pharmaxis is focussed on developing small
molecular weight inhibitors of LOXL2 in tablet form. LOXL2 is an
enzyme that stiffens scar tissue by enabling cross-links to form
between collagen fibres (a major constituent of scar tissue). The
build-up of scar tissue compromises normal organ function and can
lead to organ failure and is the hallmark of the fatal lung disease
IPF and fibrotic diseases of the liver, kidney and heart.
Over the past six months, we have continued to generate data in
preclinical models to support the development of a LOXL2 inhibitor
in IPF, whilst Pharmaxis has been producing data supporting other
fibrotic conditions. Our in vitro model of IPF used lung cells
obtained from patients with IPF, and the data from the study showed
that LOXL2 inhibitors reduce cross-link formation of collagen
fibres and tissue stiffness. We also completed two successful in
vivo pharmacology studies, one in partnership with McMaster
University and one in association with Aragen Bioscience. In the in
vivo studies, inhibitors of LOXL2 reduced cross-link formation,
reduced the lung fibrosis score, and in the McMaster study, where
lung function was measured, we saw a reduction in lung stiffness.
Alongside these studies, we also successfully completed the
toxicology studies necessary to start human clinical trials and the
lead compound for a clinical trial, PXS-5382A, was selected. Post
period-end, we announced that the Phase I clinical trial of
PXS-5382A is set to commence in Q4 2017, with a completion date set
for around mid-2018.
Industry is currently particularly interested in therapies
targeting fibrosis, as demonstrated by a cluster of high profile
and high value licensing transactions completed over the last two
to three years. We are encouraged by the high level of interest
from large pharmaceutical companies looking to progress a LOXL2
inhibitor across multiple indications, and discussions with
potential partners will progress over the course of Phase I, as we
share further data, with a view to completing a transaction around
the end of the clinical trial.
IFN-beta (SNG001)
IFN-beta is a naturally-occurring protein that activates
multiple antiviral activities and is released by cells during viral
infections. Scientists from the University of Southampton and
others have shown that cells from asthmatic and COPD patients are
more vulnerable to viral infection and in experiments using cells
from patients have shown that adding IFN-beta protects cells from
infection.
In April 2017, AstraZeneca returned the rights to SNG001,
Synairgen's inhaled IFN-beta product, to Synairgen for strategic
reasons as the drug's effects on exacerbations could not be
assessed in its Phase II trial in asthma (INEXAS). At that time,
the data from the trial showed elevation in a marker of antiviral
activity (serum IP-10/CXCL-10) and a faster recovery on the lung
function parameter Peak Expiratory Flow Rate (PEFR). Changes in
other endpoints were not clinically relevant, providing little
opportunity for the drug to have an effect. Importantly, inhaled
IFN-beta was again found to be well tolerated.
Synairgen's subsequent analysis of the INEXAS dataset has shown
statistically significant changes in lung function and asthma
control in the virus-positive 'difficult to treat' patients who
received inhaled IFN-beta; the same patient classification in which
we had found the positive signal in our previous Phase II clinical
trial in asthma (SG005).
INEXAS trial data analysis
The INEXAS trial was stopped early after 121 of the 220 planned
patients had been randomised because the number of exacerbations
caused by viruses was low to a point where it would not be possible
to assess the effect of the drug. From that point onwards decisions
on the future of the programme would depend on the other endpoints
being assessed such as lung function and asthma control. Data
identifying the patients who had a confirmed virus infection
enabled an analysis of SNG001's effect on patients who had a
confirmed viral infection, and who therefore had an opportunity to
benefit from the therapy. 48% of the patients randomised had a
confirmed viral infection. We then focussed our exploratory
analysis on the patients who came from the BTS 4/5 categorisation
of asthma, the population in which we had seen the greatest
clinical benefit in Phase II clinical trial SG005. Analysis of the
data showed that the drug had a positive effect on lung function as
measured by morning Peak Expiratory Flow (difference of 38.59
L/min/day days 1-7, p=0.0208, n=18 in active group, 19 in placebo
group) and also on asthma control over the first week of treatment
(Asthma Control Questionnaire or ACQ), difference of -0.492,
p=0.0320, (n=16 in active group, 21 in placebo group). This data is
similar to the findings from our own trial (SG005) of inhaled
IFN-beta(1) : PEF change of 31.42 L/min/day days 2-14, p=0.029
(n=22 in active group, 25 in placebo group) and ACQ -0.63 p=0.004
(n=24 in active group, 30 in placebo group).
Two Phase II trials (SG005 and INEXAS) suggest that SNG001
boosts antiviral responses in the lungs, and has a beneficial
effect on lung function. In more difficult to treat patients we saw
evidence of improved asthma control during cold infections.
However, the unexpectedly low exacerbation rate (<10%) in the
INEXAS trial population suggests that the economic viability of the
drug solely in an asthma indication would be limited. This low rate
is similar to the virus-induced exacerbation rate observed in the
Aviragen trial, also reported in 2017.
Virally-driven exacerbations of COPD
Viruses have often been isolated from samples collected from
patients who have had an exacerbation of COPD and, with COPD being
the second most common cause of emergency admissions to hospital(2)
, it has always had the potential to be a substantial opportunity
for a broad spectrum anti-viral. We have already shown in in vitro
models that SNG001 protects the lung cells of COPD patients when
infected with viruses that cause exacerbations such as flu and the
common cold. However, up until now, our ability to identify those
patients who may benefit from an inhaled antiviral therapy made the
design of a prospective study challenging. This is because
exacerbations of COPD can be caused by other factors such as
bacterial infections. Two key developments during 2017 have changed
this landscape, opening up a route to the COPD market place for
SNG001 and enhancing the prospects of achieving success in the
clinical development phase:
First, studies in COPD patients published in 2017 suggest that,
looking at all colds in the study period, the risk that a cold will
cause an exacerbation of COPD is around 50%(3) and could be even
higher in particular at risk patients(4) , making COPD a very
attractive market. The exacerbation rate in the INEXAS and Aviragen
trials in asthma was below 10%.
Secondly, a novel point of care diagnostic tool has been
developed which enables rapid confirmation of the existence of a
respiratory viral infection when patients present themselves at the
hospital or trial site. This enables us to treat only those
patients who are infected with a virus, significantly reducing the
number of subjects required to show the potential effect of SNG001.
Clearly this has significant benefits in the future, allowing
accurate prescribing of an antiviral therapy quickly to those
patients who could benefit from treatment.
Synairgen's strategy for its wholly-owned SNG001 programme is to
progress into clinical development in COPD. The Company has
therefore designed a short trial for the winter of 2017/18 to
evaluate the potential of SNG001 in COPD, which is being submitted
for regulatory approval. This trial is designed to confirm the
safety of SNG001 in the COPD population (SNG001 has been well
tolerated in asthma trials), and to confirm that we can enhance
antiviral responses in these patients. We will also assess
endpoints for their suitability for a Phase IIb trial scheduled for
early 2019.
FINANCIAL REVIEW
Statement of Comprehensive Income
The loss from operations for the six months ended 30 June 2017
was GBP1.58 million (six months ended 30 June 2016: GBP1.69 million
loss, year ended 31 December 2016: GBP3.44 million loss). Research
and development expenditure at GBP1.09 million remained broadly in
line with the comparative period in 2016 (six months ended 30 June
2016: GBP1.15 million) as the Company advanced the ongoing LOXL2
collaboration with Pharmaxis through pre-clinical studies. Other
administrative costs for the period of GBP0.51 million were also
similar to the comparative period (six months ended 30 June 2016:
GBP0.53 million). The research and development tax credit increased
from GBP0.28 million to GBP0.31 million as a result of a GBP0.06
million increase in the 2016 full year claim. The loss after tax
for the period was GBP1.26 million (six months ended 30 June 2016:
GBP1.38 million) and the basic loss per share was 1.38p (six months
ended 30 June 2016: loss of 1.51p).
Statement of Financial Position and cash flows
At 30 June 2017, net assets amounted to GBP3.48 million (30 June
2016: GBP6.05 million, 31 December 2016: GBP4.69 million),
including net funds (comprising cash balances and bank deposits) of
GBP3.08 million (30 June 2016: GBP6.31 million, 31 December 2016:
GBP4.77 million).
The principal elements of the GBP1.68 million decrease in net
funds over the six months ended 30 June 2017 (six months ended 30
June 2016: GBP1.40 million decrease, year ended 31 December 2016:
GBP2.95 million decrease) were:
-- Cash used in operations of GBP1.69 million (six months ended 30 June 2016: GBP1.75 million outflow; year ended 31
December 2016: GBP3.32 million outflow); and
-- Research and development tax credits received of GBPnil (six months ended 30 June 2016: GBP0.33 million; year
ended 31 December 2016: GBP0.33 million). Tax credits of GBP0.62 million relating to the 2016 research and
development claim were received post period-end in August 2017.
OUTLOOK
We look forward to announcing the commencement of the Phase I
trial of PXS-5382A (LOXL2 inhibitor), which is directed to the very
major conditions such as IPF and NASH, where fibrosis is a
significant cause of morbidity and mortality.
We are excited about progressing the development of SNG001 into
COPD, with a Phase II trial in targeted "at risk" patients in the
final stages of preparation. In parallel, we are considering
optimal financing strategies to enable us to progress this exciting
development over the medium term.
Simon Shaw Richard Marsden
Chairman Chief Executive Officer
26 September 2017
References:
1. Djukanovic R, et al. The Effect of Inhaled IFN-<BETA> on Worsening of Asthma Symptoms Caused by Viral Infections.
A Randomized Trial. Am J Respir Crit Care Med 2014 Jul 15; 190(2): 145-154
2. Department of Health. An Outcomes Strategy for Chronic Obstructive Pulmonary Disease (COPD) and Asthma in
England. Published July 2011
3. Johnston NW, et al. Colds as predictors of the onset and severity of COPD exacerbations International Journal of
COPD 2017:12: 839-848
4. Wilkinson TMA, et al. A prospective, observational cohort study of the seasonal dynamics of airway pathogens in
the aetiology of exacerbations in COPD Thorax 2017;0:1-9. Doi:10.1136/thoraxjnl=2016-209023
Consolidated Statement of Comprehensive Income
for the six months ended 30 June 2017
Unaudited Unaudited Audited
Six months Six months Year
ended ended ended
30 30 31
June June December
2017 2016 2016
Notes GBP000 GBP000 GBP000
Revenue 25 - -
Research and development
expenditure (1,092) (1,153) (2,418)
Other administrative
expenses (509) (533) (1,024)
------------------------------- --------- ------------ ------------ ----------
Total administrative
expenses (1,601) (1,686) (3,442)
Loss from operations (1,576) (1,686) (3,442)
Finance income 8 22 38
Loss before tax (1,568) (1,664) (3,404)
Tax credit 2 308 282 587
------------------------------- --------- ------------ ------------ ----------
Loss and total comprehensive
loss for the period
attributable to equity
holders of the parent (1,260) (1,382) (2,817)
------------------------------- --------- ------------ ------------ ----------
Loss per ordinary share 3
Basic and diluted loss
per ordinary share (pence) (1.38)p (1.51)p (3.08)p
------------------------------- --------- ------------ ------------ ------------
Consolidated Statement of Changes in Equity (unaudited)
for the six months ended 30 June 2017
Share Share Merger Retained
capital premium reserve deficit Total
GBP000 GBP000 GBP000 GBP000 GBP000
At 1 January
2016 913 25,771 483 (19,820) 7,347
Total comprehensive
loss for the
period - - - (1,382) (1,382)
Recognition
of share-based
payments - - - 84 84
Issuance of
ordinary shares 1 - - - 1
At 30 June 2016 914 25,771 483 (21,118) 6,050
Total comprehensive
loss for the
period - - - (1,435) (1,435)
Recognition
of share-based
payments - - - 70 70
At 31 December
2016 914 25,771 483 (22,483) 4,685
Total comprehensive
loss for the
period - - - (1,260) (1,260)
Recognition
of share-based
payments - - - 59 59
At 30 June 2017 914 25,771 483 (23,684) 3,484
--------------------- --------- --------- --------- --------- --------
Consolidated Statement of Financial Position
as at 30 June 2017
Unaudited Unaudited Audited
30 30 31
June June December
2017 2016 2016
Notes GBP000 GBP000 GBP000
Assets
Non-current assets
Intangible assets 53 71 62
Property, plant and
equipment 10 17 13
----------------------------- ------ ---------- ---------- ----------
63 88 75
----------------------------- ------ ---------- ---------- ----------
Current assets
Inventories 56 56 55
Current tax receivable 868 255 560
Trade and other receivables 66 61 90
Other financial assets
- bank deposits 4 267 2,500 1,661
Cash and cash equivalents 2,817 3,811 3,104
----------------------------- ------ ---------- ---------- ----------
4,074 6,683 5,470
----------------------------- ------ ---------- ---------- ----------
Total assets 4,137 6,771 5,545
----------------------------- ------ ---------- ---------- ----------
Liabilities
Current liabilities
Trade and other payables (653) (721) (860)
----------------------------- ------ ---------- ---------- ----------
Total liabilities (653) (721) (860)
----------------------------- ------ ---------- ---------- ----------
Total net assets 3,484 6,050 4,685
----------------------------- ------ ---------- ---------- ----------
Equity
Capital and reserves
attributable to equity
holders of the parent
Share capital 914 914 914
Share premium 25,771 25,771 25,771
Merger reserve 483 483 483
Retained deficit (23,684) (21,118) (22,483)
----------------------------- ------ ---------- ---------- ----------
Total equity 3,484 6,050 4,685
----------------------------- ------ ---------- ---------- ----------
Consolidated Statement of Cash Flows
for the six months ended 30 June 2017
Unaudited Unaudited Audited
Six months Six months Year
ended ended ended
30 30 31
June June December
2017 2016 2016
GBP000 GBP000 GBP000
Cash flows from operating
activities
Loss before tax (1,568) (1,664) (3,404)
Adjustments for:
Finance income (8) (22) (38)
Depreciation 4 4 9
Amortisation 9 10 19
Share-based payment charge 59 84 154
Cash flows from operations
before changes in working
capital (1,504) (1,588) (3,260)
(Increase)/Decrease in inventories (1) - 1
Decrease in trade and other
receivables 20 49 17
Decrease in trade and other
payables (207) (215) (76)
------------------------------------ ------------ ------------ ----------
Cash used in operations (1,692) (1,754) (3,318)
Tax credit received - 330 330
------------------------------------ ------------ ------------ ----------
Net cash used in operating
activities (1,692) (1,424) (2,988)
------------------------------------ ------------ ------------ ----------
Cash flows from investing
activities
Interest received 12 24 43
Purchase of property, plant
and equipment (1) (4) (5)
Decrease in other financial
assets 1,394 1,222 2,061
------------------------------------ ------------ ------------ ----------
Net cash generated from investing
activities 1,405 1,242 2,099
------------------------------------ ------------ ------------ ----------
Cash flows from financing
activities
Proceeds from issuance of
ordinary shares - 1 1
Net cash generated from financing
activities - 1 1
------------------------------------ ------------ ------------ ----------
Decrease in cash and cash
equivalents (287) (181) (888)
Cash and cash equivalents
at beginning of period 3,104 3,992 3,992
------------------------------------ ------------ ------------ ----------
Cash and cash equivalents
at end of period 2,817 3,811 3,104
------------------------------------ ------------ ------------ ----------
Notes to the Interim Financial Information
for the six months ended 30 June 2017
1. Basis of preparation
Basis of accounting
The interim financial information, which is unaudited, has been
prepared on the basis of the accounting policies expected to apply
for the financial year to 31 December 2017 and in accordance with
recognition and measurement principles of International Financial
Reporting Standards (IFRSs) as endorsed by the European Union. The
accounting policies applied in the preparation of this interim
financial information are consistent with those used in the
financial statements for the year ended 31 December 2016 and with
those that the Company expects to apply in its financial statements
for the year ending 31 December 2017.
The interim financial information does not include all of the
information required for full annual financial statements and does
not comply with all the disclosures in IAS 34 'Interim Financial
Reporting'. Accordingly, whilst the interim financial information
has been prepared in accordance with IFRSs, it cannot be construed
as being in full compliance with IFRSs.
The financial information for the year ended 31 December 2016
does not constitute the full statutory accounts for that period.
The Annual Report and Financial Statements for the year ended 31
December 2016 have been filed with the Registrar of Companies. The
Independent Auditor's Report on the Annual Report and Financial
Statements for the year ended 31 December 2016 was unqualified, did
not draw attention to any matters by way of emphasis, and did not
contain a statement under 498(2) or 498(3) of the Companies Act
2006.
Going Concern
The directors have prepared financial forecasts to estimate the
likely cash requirements of the Group over the next twelve months.
In preparing these financial forecasts, the directors have had to
make certain assumptions with regards to the timing and amount of
future expenditure and other key factors. The directors have
attempted to take a balanced and prudent view in preparing these
forecasts, however their accuracy is uncertain.
After due consideration and review of these financial forecasts
and current cash resources, the directors consider that the Group
has adequate financial resources to continue in operational
existence for the foreseeable future (being a period of at least
twelve months from the date of this report), and for this reason
the interim financial information has been prepared on a going
concern basis.
The 30 June 2017 interim financial information was approved by a
duly appointed and authorised committee of the Board of Directors
on 26 September 2017.
2. Tax credit
The tax credit of GBP308,000 (six months ended 30 June 2016:
GBP282,000; year ended 31 December 2016: GBP587,000) includes
GBP247,000 as an estimate of the research and development tax
credit receivable in respect of the current period and GBP61,000
representing amounts unprovided for in previous periods.
3. Loss per ordinary share
Unaudited Unaudited Audited
Six months Six months Year
ended ended ended
30 June 30 June 31 December
2017 2016 2016
Loss attributable to
equity holders of the
Company (GBP000) (1,260) (1,382) (2,817)
Weighted average number
of ordinary shares
in issue 91,362,612 91,340,146 91,351,441
Notes to the Interim Financial Information
for the six months ended 30 June 2017 (continued)
3. Loss per ordinary share (continued)
The loss attributable to ordinary shareholders and weighted
average number of ordinary shares for the purpose of calculating
the diluted earnings per ordinary share are identical to those used
for basic earnings per share. This is because the exercise of share
options would have the effect of reducing the loss per ordinary
share and is therefore antidilutive under the terms of IAS 33. At
30 June 2017 there were 5,566,736 options outstanding (30 June
2016: 5,719,762 options outstanding; 31 December 2016: 5,629,647
options outstanding).
4. Other financial assets
Other financial assets comprise Sterling fixed rate bank
deposits of greater than three months' maturity at the time of
deposit.
INDEPENDENT REVIEW REPORT TO SYNAIRGEN PLC
Introduction
We have been engaged by the company to review the interim set of
financial information in the half-yearly financial report for the
six months ended 30 June 2017 which comprises the Consolidated
Statement of Comprehensive Income, the Consolidated Statement of
Changes in Equity, the Consolidated Statement of Financial
Position, the Consolidated Statement of Cash Flows and the related
notes 1 to 4.
We have read the other information contained in the half-yearly
financial report and considered whether it contains any apparent
misstatements or material inconsistencies with the information in
the interim set of financial information.
Directors' responsibilities
The interim report, including the financial information
contained therein, is the responsibility of and has been approved
by the directors. The directors are responsible for preparing the
interim report in accordance with the rules of the London Stock
Exchange for companies trading securities on AIM which require that
the half-yearly report be presented and prepared in a form
consistent with that which will be adopted in the company's annual
accounts having regard to the accounting standards applicable to
such annual accounts.
Our responsibility
Our responsibility is to express to the company a conclusion on
the interim set of financial information in the half-yearly
financial report based on our review.
Our report has been prepared in accordance with the terms of our
engagement to assist the company in meeting the requirements of the
rules of the London Stock Exchange for companies trading securities
on AIM and for no other purpose. No person is entitled to rely on
this report unless such a person is a person entitled to rely upon
this report by virtue of and for the purpose of our terms of
engagement or has been expressly authorised to do so by our prior
written consent. Save as above, we do not accept responsibility for
this report to any other person or for any other purpose and we
hereby expressly disclaim any and all such liability.
Scope of review
We conducted our review in accordance with International
Standard on Review Engagements (UK and Ireland) 2410, "Review of
Interim Financial Information Performed by the Independent Auditor
of the Entity", issued by the Auditing Practices Board for use in
the United Kingdom. A review of interim financial information
consists of making enquiries, primarily of persons responsible for
financial and accounting matters, and applying analytical and other
review procedures. A review is substantially less in scope than an
audit conducted in accordance with International Standards on
Auditing (UK and Ireland) and consequently does not enable us to
obtain assurance that we would become aware of all significant
matters that might be identified in an audit. Accordingly, we do
not express an audit opinion.
Conclusion
Based on our review, nothing has come to our attention that
causes us to believe that the interim set of financial information
in the half-yearly financial report for the six months ended 30
June 2017 is not prepared, in all material respects, in accordance
with the rules of the London Stock Exchange for companies trading
securities on AIM.
BDO LLP
Chartered Accountants and Registered Auditors
Southampton
United Kingdom
26 September 2017
BDO LLP is a limited liability partnership registered in England
and Wales (with registered number OC305127).
This information is provided by RNS
The company news service from the London Stock Exchange
END
IR OKADBOBKDNCB
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