Bruker Introduces Beta-Lactamase Testing, New Productivity Software Modules, as well as MBT Pilot & MBT Galaxy Accessories fo...
12 May 2014 - 7:00PM
Business Wire
MBT STAR-BL software for patented functional
beta-lactamase testing is first high-value module in new MBT STAR
(Selective Testing of Antibiotic Resistance) family.
At the 24th European Congress of Clinical Microbiology and
Infectious Diseases (ECCMID), Bruker introduces new and expanded
research-use only (RUO) capabilities for the MALDI Biotyper™
platform.
MBT Galaxy (Photo: Business Wire)
The MALDI Biotyper (MBT) is the market-leading system for
microbial identification based on MALDI-TOF mass spectrometry. It
is widely used in industrial microbiology, animal health, food
safety and its IVD and FDA-cleared versions are changing the
paradigm in clinical microbiology. With nearly 1,200 customer
systems, the MBT platform has become an accepted
laboratory-standard for next-generation microbial identification
and emerging further high-value functional assays. The MALDI
Biotyper RUO and IVD-CE versions cover a broad range of about 2,300
species with more than 5,600 well-characterized microbial isolates
from gram-negative bacteria, gram-positive bacteria, yeasts,
multicellular fungi and mycobacteria. Microbial identification with
the MALDI Biotyper is done using proteomic fingerprinting, where
unique species-specific patterns are automatically compared with
reference spectra in the MALDI Biotyper library.
Due to the modular design of the MALDI Biotyper software, the
system can be configured according to the specific needs of each
laboratory: the basic microbial identification functionality is now
available in versions for clinical routine laboratories (IVD), for
industrial applications and for research-use-only (RUO)
purposes.
Industrial and research customers can configure their MALDI
Biotyper systems with further functionality by adding various new
or expanded RUO software modules or hardware accessories:
- The MBT Explorer module provides
multiple sophisticated bioinformatics approaches for spectra
comparison, statistical data interpretation and for the generation
of customer-specific reference library entries (main spectra) of
strains of special interest. Such sub-libraries can be exported and
re-imported in networks of collaborating laboratories.
- The MBT Satellite module allows
for an efficient paperless setup. Multiple MBT Satellite modules
can be used for laboratories with multiple microbiology
work-benches.
- The MBT Sepsityper module
supports the analyses of data generated from positive blood culture
samples. This software complements the MALDI Sepsityper kit with
streamlined data interpretation for this workflow.
- The MBT STAR-BL (Beta Lactamase)
module is part of the new MBT STAR assay family for
Selective Testing of Antibiotic
Resistance, and enables patented functional beta-lactamase
testing for selected antibiotics. The MBT STAR-BL software monitors
the mass shifts introduced by enzymatic degradation of betalactam
antibiotics, like some penicillins, 3rd generation cephalosporins
and carbapenems. These changes are monitored by direct measurements
of molecular weights without the need of any labelling by probes or
antibodies. Bruker is currently gathering feedback from infectious
disease researchers on its performance. Due to strong demand for
this type of resistance information, future IVD versions are
planned.
- As use of the MALDI Biotyper continues
to increase for industrial microbiology in pharma, food or consumer
goods industries, data integrity topics like user management, audit
trail and data archiving are of special importance. For these
customers, Bruker now offers the new MBT Compliance Assistance
Module to support 21 CFR Part 11 requirements.
- MBT Translator and MBT
Integrator modules provide functionality to connect data
generated with the MALDI Biotyper to laboratory information systems
(LIS). MALDI Biotyper results are translated into the language of
the LIS and are integrated with information available in the
LIS.
- The MBT Pilot™ is a
hardware accessory to support the light-guided preparation of
target plates. In combination with the MBT Satellite software it
allows for a paperless and barcode-tracked workflow with full
traceability. The ergonomically-shaped MBT Pilot guides users
during the preparation of plates, reducing the possibility of
specimen transfer errors.
- The MBT Galaxy™ reduces
the manual workload during preparation of sample target plates and
also introduces significant quality control steps, like controlled
reagent droplet size, controlled drying atmosphere and control of
quality of the matrix preparation. This bench-top automation device
standardizes the preparation of samples with quality controls for
reagent additions. The MBT Galaxy eliminates the need for manual
reagent pipetting, reducing repetitive motions and labor costs
required for target preparation. The MBT Galaxy is equipped with
on-board barcode reading to connect directly to the MALDI Biotyper
server.
Dr. Ulrich Eigner, Head of Study Department at Limbach
Laboratory in Heidelberg, Germany, commented: “We have been working
with Bruker´s MALDI Biotyper system in our network of microbiology
laboratories for several years and we are very pleased with the
analytical performance. With the MBT Pilot and MBT Galaxy Bruker
now introduces further smart and convincing workflow improvement
tools.”
Dr. Wolfgang Pusch, Executive Vice President - Microbiology
Business at Bruker Daltonics, explained: “We believe that our MALDI
Biotyper can now provide even more than best-in-class
identification to microbiology laboratories. That’s why we are
continuously working on adding additional high-value functional
assays, new software tools, library extensions and productivity
tools to the MALDI Biotyper platform.”
About the Bruker MALDI Biotyper
The MALDI Biotyper family of systems enables molecular
identification, and taxonomical classification or dereplication of
microorganisms like bacteria, yeasts and fungi. Classification and
identification of microorganisms is achieved reliably and quickly
using proteomic fingerprinting by high-throughput MALDI-TOF mass
spectrometry. The MALDI Biotyper uses a molecular approach based on
specific proteomic fingerprints from bacterial strains and
published studies have highlighted the greater accuracy and lower
cost offered, as well as the typically much faster time-to-result
(TTR).
Applications of the various MALDI Biotyper solutions include
clinical routine microbial identification, environmental and
pharmaceutical analysis, taxonomical research, food and consumer
product safety and quality control, as well as marine microbiology.
In many European and international laboratories the MALDI Biotyper
has replaced classical biochemical testing for bacterial
identification in the past five years due to the accuracy, speed,
extensive species coverage, ease of use and cost effectiveness of
the system. Classical biochemical techniques detect different
metabolic properties of microorganisms, can take many hours or even
days for completion, and they often lack specificity.
The robust MALDI Biotyper method requires minimal sample
preparation and offers low consumables cost. The products of the
MALDI Biotyper family are available in a research-use-only (RUO)
version, as the U.S. FDA-cleared MALDI Biotyper CA System, or in an
IVD-CE version according to EU directive EC/98/79. The MALDI
Biotyper also has medical device registrations in numerous other
countries. RUO versions of the MALDI Biotyper even allow selected
high-value antimicrobial resistance tests in translational
research.
ABOUT BRUKER CORPORATION (NASDAQ: BRKR)Bruker is a
leading provider of high-performance scientific instruments and
solutions for molecular and materials research, as well as for
industrial, diagnostics and applied analysis. For more information:
www.bruker.com.
Photos/Multimedia Gallery Available:
http://www.businesswire.com/multimedia/home/20140512005183/en/
Bruker Daltonik GmbH, Bremen, GermanyDr. Winfried Busch,
+49-421-2205-1242Winfried.Busch@bdal.de
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